Major Depressive Disorder with Suicidal Ideation or Intent in Taiwan: A Discrete Choice Experiment of Psychiatrists’ Treatment Preferences
Objective: In this study, we intended to understand how psychiatrists in Taiwan value different attributes of pharmacological treatments for major depressive disorder with suicidal ideation or intent (MDSI). Novel therapies for MDSI differ from standard treatments in their route of administration, e...
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2025-04-01
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| Series: | Taiwanese Journal of Psychiatry |
| Subjects: | |
| Online Access: | https://journals.lww.com/10.4103/TPSY.TPSY_20_25 |
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| author | Simon Fifer Brittany Keen Keira Joann Herr Chih-Lin Chiang Thomas Webb |
| author_facet | Simon Fifer Brittany Keen Keira Joann Herr Chih-Lin Chiang Thomas Webb |
| author_sort | Simon Fifer |
| collection | DOAJ |
| description | Objective:
In this study, we intended to understand how psychiatrists in Taiwan value different attributes of pharmacological treatments for major depressive disorder with suicidal ideation or intent (MDSI). Novel therapies for MDSI differ from standard treatments in their route of administration, efficacy, and side effect profiles.
Methods:
Psychiatrists from Taiwan completed an online survey with a discrete choice experiment (DCE). MDSI treatment alternatives and standard of care oral antidepressants were described by cost, efficacy (24 h and one month), and side effect profile (drowsiness, nausea/headache/dizziness, dissociation, and short-term increase in blood pressure). The DCE responses were analyzed using a mixed multinomial logit model is correct.
Results:
Psychiatrists from Taiwan (n = 83) showed a significant preference for a novel adjunct intranasal therapy over the current standard of care, oral antidepressants (β = [−8.386 ± 1.45369], t-ratio = −5.77, p < 0.001). Both efficacy and side effect profiles were found to be of importance. Nausea, headache, and dizziness were the least preferred side effects (β = [−0.12323 ± 0.02174], t-ratio = −5.67, p < 0.001). When cost was included in the model, the psychiatrists tended to prioritize those treatments with a low cost to patients or that was reimbursed. The highest relative attribute importance was response rate at 24 h (29.54%).
Conclusion:
Psychiatrists in Taiwan preferred treatment features of novel therapies for MDSI. These findings could be strengthened through undertaking a similar DCE with patients. |
| format | Article |
| id | doaj-art-e8d11d8bdad34231a60079c50d154739 |
| institution | Kabale University |
| issn | 1028-3684 2666-2078 |
| language | English |
| publishDate | 2025-04-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Taiwanese Journal of Psychiatry |
| spelling | doaj-art-e8d11d8bdad34231a60079c50d1547392025-08-20T03:30:10ZengWolters Kluwer Medknow PublicationsTaiwanese Journal of Psychiatry1028-36842666-20782025-04-0139210211010.4103/TPSY.TPSY_20_25Major Depressive Disorder with Suicidal Ideation or Intent in Taiwan: A Discrete Choice Experiment of Psychiatrists’ Treatment PreferencesSimon FiferBrittany KeenKeira Joann HerrChih-Lin ChiangThomas WebbObjective: In this study, we intended to understand how psychiatrists in Taiwan value different attributes of pharmacological treatments for major depressive disorder with suicidal ideation or intent (MDSI). Novel therapies for MDSI differ from standard treatments in their route of administration, efficacy, and side effect profiles. Methods: Psychiatrists from Taiwan completed an online survey with a discrete choice experiment (DCE). MDSI treatment alternatives and standard of care oral antidepressants were described by cost, efficacy (24 h and one month), and side effect profile (drowsiness, nausea/headache/dizziness, dissociation, and short-term increase in blood pressure). The DCE responses were analyzed using a mixed multinomial logit model is correct. Results: Psychiatrists from Taiwan (n = 83) showed a significant preference for a novel adjunct intranasal therapy over the current standard of care, oral antidepressants (β = [−8.386 ± 1.45369], t-ratio = −5.77, p < 0.001). Both efficacy and side effect profiles were found to be of importance. Nausea, headache, and dizziness were the least preferred side effects (β = [−0.12323 ± 0.02174], t-ratio = −5.67, p < 0.001). When cost was included in the model, the psychiatrists tended to prioritize those treatments with a low cost to patients or that was reimbursed. The highest relative attribute importance was response rate at 24 h (29.54%). Conclusion: Psychiatrists in Taiwan preferred treatment features of novel therapies for MDSI. These findings could be strengthened through undertaking a similar DCE with patients.https://journals.lww.com/10.4103/TPSY.TPSY_20_25costsesketaminetreatment patternstreatment-resistant depression |
| spellingShingle | Simon Fifer Brittany Keen Keira Joann Herr Chih-Lin Chiang Thomas Webb Major Depressive Disorder with Suicidal Ideation or Intent in Taiwan: A Discrete Choice Experiment of Psychiatrists’ Treatment Preferences Taiwanese Journal of Psychiatry costs esketamine treatment patterns treatment-resistant depression |
| title | Major Depressive Disorder with Suicidal Ideation or Intent in Taiwan: A Discrete Choice Experiment of Psychiatrists’ Treatment Preferences |
| title_full | Major Depressive Disorder with Suicidal Ideation or Intent in Taiwan: A Discrete Choice Experiment of Psychiatrists’ Treatment Preferences |
| title_fullStr | Major Depressive Disorder with Suicidal Ideation or Intent in Taiwan: A Discrete Choice Experiment of Psychiatrists’ Treatment Preferences |
| title_full_unstemmed | Major Depressive Disorder with Suicidal Ideation or Intent in Taiwan: A Discrete Choice Experiment of Psychiatrists’ Treatment Preferences |
| title_short | Major Depressive Disorder with Suicidal Ideation or Intent in Taiwan: A Discrete Choice Experiment of Psychiatrists’ Treatment Preferences |
| title_sort | major depressive disorder with suicidal ideation or intent in taiwan a discrete choice experiment of psychiatrists treatment preferences |
| topic | costs esketamine treatment patterns treatment-resistant depression |
| url | https://journals.lww.com/10.4103/TPSY.TPSY_20_25 |
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