A study of the clinico-demographical profile of different dengue serotypes circulating in a Southern district of West Bengal, India
Background: Dengue virus (DENV) which is endemic in many tropical and subtropical areas around the world has four serotypes (DENV1, DENV2, DENV3and DENV4), this viral infection can either cause mild febrile illness Dengue fever or severe, such as Dengue hemorrhagic fever or Dengue Shock Syndrome. Th...
Saved in:
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Manipal College of Medical Sciences, Pokhara
2025-02-01
|
| Series: | Asian Journal of Medical Sciences |
| Subjects: | |
| Online Access: | https://ajmsjournal.info/index.php/AJMS/article/view/4271 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832574946781429760 |
|---|---|
| author | Sayani Bose Feradica D Laloo Partha Pratim Maity Anirban Bhaduri |
| author_facet | Sayani Bose Feradica D Laloo Partha Pratim Maity Anirban Bhaduri |
| author_sort | Sayani Bose |
| collection | DOAJ |
| description | Background: Dengue virus (DENV) which is endemic in many tropical and subtropical areas around the world has four serotypes (DENV1, DENV2, DENV3and DENV4), this viral infection can either cause mild febrile illness Dengue fever or severe, such as Dengue hemorrhagic fever or Dengue Shock Syndrome. The dominant dengue serotypes in a region often change over time and the infecting serotypes are seen to have an impact on the clinical presentation and outcome of the patient.
Aims and Objectives: Finding the proportion of Dengue non-structural protein 1 (NS1) reactive cases among patients with fever <5 days as well as molecular detection of the prevalent dengue serotypes.
Materials and Methods: This study was conducted at the Department of Microbiology at Tamralipto Government Medical College and Hospital, East Midnapore, West Bengal. Blood collected from patients suffering from fever <5 days was tested for Dengue NS1. Samples reactive for Dengue NS1 were further tested for dengue serotyping by reverse transcription polymerase chain reaction. The results obtained were analyzed and interpreted.
Results: Out of 7574 samples of fever patients tested for dengue NS1, 882 samples were reactive and among these 882 NS1 samples, (DENV) ribonucleic acid was detected in 714 samples. The predominant serotype detected was DENV2 (63.73%) followed by DENV3 (26.89%), DENV1 (6.72%), and DENV4 (2.66%). Among the NS1 reactive patients, 52 (5.90%) patients suffered from hemorrhagic complications; among whom the predominant serotype was DENV2 followed by DENV3.
Conclusion: The infecting dengue serotype seems to have an impact on the disease severity and early detection may help us predict prognosis and need for hospital monitoring, hence reducing complications and mortality. Since the region-wise serotypes are diverse and change every few years, molecular surveillance helps in the early detection of any shift from previously circulating serotypes and thus prepares for handling more severe dengue cases. |
| format | Article |
| id | doaj-art-e8d0736138fa44eaab9ded7ecd40b5ff |
| institution | Kabale University |
| issn | 2467-9100 2091-0576 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | Manipal College of Medical Sciences, Pokhara |
| record_format | Article |
| series | Asian Journal of Medical Sciences |
| spelling | doaj-art-e8d0736138fa44eaab9ded7ecd40b5ff2025-02-01T12:10:50ZengManipal College of Medical Sciences, PokharaAsian Journal of Medical Sciences2467-91002091-05762025-02-011626973https://doi.org/10.71152/ajms.v16i2.4271A study of the clinico-demographical profile of different dengue serotypes circulating in a Southern district of West Bengal, IndiaSayani Bose 0https://orcid.org/0009-0006-3578-4732Feradica D Laloo 1https://orcid.org/0009-0003-8425-8219Partha Pratim Maity2https://orcid.org/0009-0006-3257-6946Anirban Bhaduri 3https://orcid.org/0000-0001-6131-4597Senior Resident, Department of Microbiology, Tamralipto Government Medical College and Hospital, Purba Midnapore, West Bengal, India Senior Resident, Department of Microbiology, Jalpaiguri Government Medical College and Hospital, Jalpaiguri, West Bengal, India Assistant Professor, Department of Microbiology, Tamralipto Government Medical College and Hospital, Purba Midnapore, West Bengal, India Associate Professor and Head, Department of Microbiology, Tamralipto Government Medical College and Hospital, Purba Midnapore, West Bengal, India Background: Dengue virus (DENV) which is endemic in many tropical and subtropical areas around the world has four serotypes (DENV1, DENV2, DENV3and DENV4), this viral infection can either cause mild febrile illness Dengue fever or severe, such as Dengue hemorrhagic fever or Dengue Shock Syndrome. The dominant dengue serotypes in a region often change over time and the infecting serotypes are seen to have an impact on the clinical presentation and outcome of the patient. Aims and Objectives: Finding the proportion of Dengue non-structural protein 1 (NS1) reactive cases among patients with fever <5 days as well as molecular detection of the prevalent dengue serotypes. Materials and Methods: This study was conducted at the Department of Microbiology at Tamralipto Government Medical College and Hospital, East Midnapore, West Bengal. Blood collected from patients suffering from fever <5 days was tested for Dengue NS1. Samples reactive for Dengue NS1 were further tested for dengue serotyping by reverse transcription polymerase chain reaction. The results obtained were analyzed and interpreted. Results: Out of 7574 samples of fever patients tested for dengue NS1, 882 samples were reactive and among these 882 NS1 samples, (DENV) ribonucleic acid was detected in 714 samples. The predominant serotype detected was DENV2 (63.73%) followed by DENV3 (26.89%), DENV1 (6.72%), and DENV4 (2.66%). Among the NS1 reactive patients, 52 (5.90%) patients suffered from hemorrhagic complications; among whom the predominant serotype was DENV2 followed by DENV3. Conclusion: The infecting dengue serotype seems to have an impact on the disease severity and early detection may help us predict prognosis and need for hospital monitoring, hence reducing complications and mortality. Since the region-wise serotypes are diverse and change every few years, molecular surveillance helps in the early detection of any shift from previously circulating serotypes and thus prepares for handling more severe dengue cases.https://ajmsjournal.info/index.php/AJMS/article/view/4271dengue serotypes; non-structural protein 1 antigen; dengue virus |
| spellingShingle | Sayani Bose Feradica D Laloo Partha Pratim Maity Anirban Bhaduri A study of the clinico-demographical profile of different dengue serotypes circulating in a Southern district of West Bengal, India Asian Journal of Medical Sciences dengue serotypes; non-structural protein 1 antigen; dengue virus |
| title | A study of the clinico-demographical profile of different dengue serotypes circulating in a Southern district of West Bengal, India |
| title_full | A study of the clinico-demographical profile of different dengue serotypes circulating in a Southern district of West Bengal, India |
| title_fullStr | A study of the clinico-demographical profile of different dengue serotypes circulating in a Southern district of West Bengal, India |
| title_full_unstemmed | A study of the clinico-demographical profile of different dengue serotypes circulating in a Southern district of West Bengal, India |
| title_short | A study of the clinico-demographical profile of different dengue serotypes circulating in a Southern district of West Bengal, India |
| title_sort | study of the clinico demographical profile of different dengue serotypes circulating in a southern district of west bengal india |
| topic | dengue serotypes; non-structural protein 1 antigen; dengue virus |
| url | https://ajmsjournal.info/index.php/AJMS/article/view/4271 |
| work_keys_str_mv | AT sayanibose astudyoftheclinicodemographicalprofileofdifferentdengueserotypescirculatinginasoutherndistrictofwestbengalindia AT feradicadlaloo astudyoftheclinicodemographicalprofileofdifferentdengueserotypescirculatinginasoutherndistrictofwestbengalindia AT parthapratimmaity astudyoftheclinicodemographicalprofileofdifferentdengueserotypescirculatinginasoutherndistrictofwestbengalindia AT anirbanbhaduri astudyoftheclinicodemographicalprofileofdifferentdengueserotypescirculatinginasoutherndistrictofwestbengalindia AT sayanibose studyoftheclinicodemographicalprofileofdifferentdengueserotypescirculatinginasoutherndistrictofwestbengalindia AT feradicadlaloo studyoftheclinicodemographicalprofileofdifferentdengueserotypescirculatinginasoutherndistrictofwestbengalindia AT parthapratimmaity studyoftheclinicodemographicalprofileofdifferentdengueserotypescirculatinginasoutherndistrictofwestbengalindia AT anirbanbhaduri studyoftheclinicodemographicalprofileofdifferentdengueserotypescirculatinginasoutherndistrictofwestbengalindia |