Overweight might Affect the Live Birth Rate after Frozen Thawed Embryo Transfer Cycles in Chinese Women
Background: Overweight affects about 34.3% of Chinese adults, especially women of childbearing age. The purpose of this study was to investigate whether overweight affect the live birth rate of frozen-thawed embryo transfer (FET) cycles in Chinese mothers. Methods: This retrospective case-control st...
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| Format: | Article |
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IMR Press
2023-05-01
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| Series: | Clinical and Experimental Obstetrics & Gynecology |
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| Online Access: | https://www.imrpress.com/journal/CEOG/50/5/10.31083/j.ceog5005103 |
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| author | Meihong Cai Sushi Jiang Xiaohuan Luo Yaqiao Zhu Wei Wang Yaya Peng Wei Xia |
| author_facet | Meihong Cai Sushi Jiang Xiaohuan Luo Yaqiao Zhu Wei Wang Yaya Peng Wei Xia |
| author_sort | Meihong Cai |
| collection | DOAJ |
| description | Background: Overweight affects about 34.3% of Chinese adults, especially women of childbearing age. The purpose of this study was to investigate whether overweight affect the live birth rate of frozen-thawed embryo transfer (FET) cycles in Chinese mothers. Methods: This retrospective case-control study was conducted in all patients undergoing FET cycles from May 2016 to October 2020 at a single center. A total of 969 FET cycles performed in 632 patients were included in the analysis. Patients were divided into the four groups based on the mother’s body mass index (BMI): Group 1: BMI <18.5 kg/m2; Group 2: 18.5 kg/m2 ≤ BMI <24 kg/m2; Group 3: 24 kg/m2 ≤ BMI <28 kg/m2; Group 4: BMI ≥28 kg/m2. The main outcome indicator was the live birth rate per FET cycle. The secondary endpoints included rates of biochemical clinical pregnancy, clinical pregnancy, implantation, multiple pregnancy and miscarriage. Results: Ovarian reserve parameters were similar among the four groups (p = 0.382 for anti-Müllerian hormone and p = 0.195 for antral follicle count). Additionally, the rates of chemical pregnancy, clinical pregnancy, implantation and live birth were comparable in the four groups. Pregnancy outcomes were similar among the four groups using logistic regression analysis adjusting for age, anti-Müllerian hormone (AMH), antral follicle count (AFC), endometrial thickness, indication combined with polycystic ovarian syndrome (PCOS), duration of infertility (years), stage of embryos transferred, previous attempts, protocol of endometrial preparation, number of embryos transferred, and BMI. A decreasing tendency in the rates of clinical pregnancy (p = 0.032) and live birth (p = 0.011) with BMI change was observed through Chi Square for Trend test. Conclusions: Overweight might reduce the possibility of live birth after FET cycles in Chinese mothers. |
| format | Article |
| id | doaj-art-e8c7c77deda042b7bc05ae143d33a9d6 |
| institution | DOAJ |
| issn | 0390-6663 |
| language | English |
| publishDate | 2023-05-01 |
| publisher | IMR Press |
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| series | Clinical and Experimental Obstetrics & Gynecology |
| spelling | doaj-art-e8c7c77deda042b7bc05ae143d33a9d62025-08-20T03:21:10ZengIMR PressClinical and Experimental Obstetrics & Gynecology0390-66632023-05-0150510310.31083/j.ceog5005103S0390-6663(22)02002-4Overweight might Affect the Live Birth Rate after Frozen Thawed Embryo Transfer Cycles in Chinese WomenMeihong Cai0Sushi Jiang1Xiaohuan Luo2Yaqiao Zhu3Wei Wang4Yaya Peng5Wei Xia6Department of Reproductive Medicine Centre, Guangzhou First People’s Hospital, School of Medicine, South China University of Technology, 510000 Guangzhou, Guangdong, ChinaDepartment of Reproductive Medicine Centre, Guangzhou First People’s Hospital, School of Medicine, South China University of Technology, 510000 Guangzhou, Guangdong, ChinaDepartment of Reproductive Medicine Centre, Guangzhou First People’s Hospital, School of Medicine, South China University of Technology, 510000 Guangzhou, Guangdong, ChinaDepartment of Reproductive Medicine Centre, Guangzhou First People’s Hospital, School of Medicine, South China University of Technology, 510000 Guangzhou, Guangdong, ChinaDepartment of Reproductive Medicine Centre, Guangzhou First People’s Hospital, School of Medicine, South China University of Technology, 510000 Guangzhou, Guangdong, ChinaDepartment of Reproductive Medicine Centre, Guangzhou First People’s Hospital, School of Medicine, South China University of Technology, 510000 Guangzhou, Guangdong, ChinaDepartment of Reproductive Medicine Centre, Guangzhou First People’s Hospital, School of Medicine, South China University of Technology, 510000 Guangzhou, Guangdong, ChinaBackground: Overweight affects about 34.3% of Chinese adults, especially women of childbearing age. The purpose of this study was to investigate whether overweight affect the live birth rate of frozen-thawed embryo transfer (FET) cycles in Chinese mothers. Methods: This retrospective case-control study was conducted in all patients undergoing FET cycles from May 2016 to October 2020 at a single center. A total of 969 FET cycles performed in 632 patients were included in the analysis. Patients were divided into the four groups based on the mother’s body mass index (BMI): Group 1: BMI <18.5 kg/m2; Group 2: 18.5 kg/m2 ≤ BMI <24 kg/m2; Group 3: 24 kg/m2 ≤ BMI <28 kg/m2; Group 4: BMI ≥28 kg/m2. The main outcome indicator was the live birth rate per FET cycle. The secondary endpoints included rates of biochemical clinical pregnancy, clinical pregnancy, implantation, multiple pregnancy and miscarriage. Results: Ovarian reserve parameters were similar among the four groups (p = 0.382 for anti-Müllerian hormone and p = 0.195 for antral follicle count). Additionally, the rates of chemical pregnancy, clinical pregnancy, implantation and live birth were comparable in the four groups. Pregnancy outcomes were similar among the four groups using logistic regression analysis adjusting for age, anti-Müllerian hormone (AMH), antral follicle count (AFC), endometrial thickness, indication combined with polycystic ovarian syndrome (PCOS), duration of infertility (years), stage of embryos transferred, previous attempts, protocol of endometrial preparation, number of embryos transferred, and BMI. A decreasing tendency in the rates of clinical pregnancy (p = 0.032) and live birth (p = 0.011) with BMI change was observed through Chi Square for Trend test. Conclusions: Overweight might reduce the possibility of live birth after FET cycles in Chinese mothers.https://www.imrpress.com/journal/CEOG/50/5/10.31083/j.ceog5005103overweightlive birth ratefrozen-thawed embryo transfer cycle |
| spellingShingle | Meihong Cai Sushi Jiang Xiaohuan Luo Yaqiao Zhu Wei Wang Yaya Peng Wei Xia Overweight might Affect the Live Birth Rate after Frozen Thawed Embryo Transfer Cycles in Chinese Women Clinical and Experimental Obstetrics & Gynecology overweight live birth rate frozen-thawed embryo transfer cycle |
| title | Overweight might Affect the Live Birth Rate after Frozen Thawed Embryo Transfer Cycles in Chinese Women |
| title_full | Overweight might Affect the Live Birth Rate after Frozen Thawed Embryo Transfer Cycles in Chinese Women |
| title_fullStr | Overweight might Affect the Live Birth Rate after Frozen Thawed Embryo Transfer Cycles in Chinese Women |
| title_full_unstemmed | Overweight might Affect the Live Birth Rate after Frozen Thawed Embryo Transfer Cycles in Chinese Women |
| title_short | Overweight might Affect the Live Birth Rate after Frozen Thawed Embryo Transfer Cycles in Chinese Women |
| title_sort | overweight might affect the live birth rate after frozen thawed embryo transfer cycles in chinese women |
| topic | overweight live birth rate frozen-thawed embryo transfer cycle |
| url | https://www.imrpress.com/journal/CEOG/50/5/10.31083/j.ceog5005103 |
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