Harnessing the power of genomics in hypertension: tip of the iceberg?
Despite the blaze of advancing knowledge on its complex genetic architecture, hypertension remains an elusive condition. Genetic studies of blood pressure have yielded bitter-sweet results thus far with the identification of more than 2,000 genetic loci, though the candidate causal genes and biologi...
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| Format: | Article |
| Language: | English |
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Cambridge University Press
2025-01-01
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| Series: | Cambridge Prisms: Precision Medicine |
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| Online Access: | https://www.cambridge.org/core/product/identifier/S2752614325000018/type/journal_article |
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| author | Hafiz Naderi Helen R. Warren Patricia B. Munroe |
| author_facet | Hafiz Naderi Helen R. Warren Patricia B. Munroe |
| author_sort | Hafiz Naderi |
| collection | DOAJ |
| description | Despite the blaze of advancing knowledge on its complex genetic architecture, hypertension remains an elusive condition. Genetic studies of blood pressure have yielded bitter-sweet results thus far with the identification of more than 2,000 genetic loci, though the candidate causal genes and biological pathways remain largely unknown. The era of big data and sophisticated statistical tools has propelled insights into pathophysiology and causal inferences. However, new genetic risk tools for hypertension are the tip of the iceberg, and applications of genomic technology are likely to proliferate. We review the genomics of hypertension, exploring the significant milestones in our current understanding of this condition and the progress towards personalised treatment and management for hypertension. |
| format | Article |
| id | doaj-art-e8c7b53257014f3b9d6136a5ba3d8847 |
| institution | DOAJ |
| issn | 2752-6143 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Cambridge University Press |
| record_format | Article |
| series | Cambridge Prisms: Precision Medicine |
| spelling | doaj-art-e8c7b53257014f3b9d6136a5ba3d88472025-08-20T03:11:26ZengCambridge University PressCambridge Prisms: Precision Medicine2752-61432025-01-01310.1017/pcm.2025.1Harnessing the power of genomics in hypertension: tip of the iceberg?Hafiz Naderi0https://orcid.org/0000-0002-3217-780XHelen R. Warren1https://orcid.org/0000-0003-0511-1386Patricia B. Munroe2https://orcid.org/0000-0002-4176-2947William Harvey Research Institute, Queen Mary University of London, London, UK Barts Heart Centre, St Bartholomew’s Hospital, West Smithfield, London, UK National Institute of Health and Care Research Barts Biomedical Research Centre, Queen Mary University of London, London, UKWilliam Harvey Research Institute, Queen Mary University of London, London, UK National Institute of Health and Care Research Barts Biomedical Research Centre, Queen Mary University of London, London, UKWilliam Harvey Research Institute, Queen Mary University of London, London, UK National Institute of Health and Care Research Barts Biomedical Research Centre, Queen Mary University of London, London, UKDespite the blaze of advancing knowledge on its complex genetic architecture, hypertension remains an elusive condition. Genetic studies of blood pressure have yielded bitter-sweet results thus far with the identification of more than 2,000 genetic loci, though the candidate causal genes and biological pathways remain largely unknown. The era of big data and sophisticated statistical tools has propelled insights into pathophysiology and causal inferences. However, new genetic risk tools for hypertension are the tip of the iceberg, and applications of genomic technology are likely to proliferate. We review the genomics of hypertension, exploring the significant milestones in our current understanding of this condition and the progress towards personalised treatment and management for hypertension.https://www.cambridge.org/core/product/identifier/S2752614325000018/type/journal_articlehypertensionprecision medicinegenomics |
| spellingShingle | Hafiz Naderi Helen R. Warren Patricia B. Munroe Harnessing the power of genomics in hypertension: tip of the iceberg? Cambridge Prisms: Precision Medicine hypertension precision medicine genomics |
| title | Harnessing the power of genomics in hypertension: tip of the iceberg? |
| title_full | Harnessing the power of genomics in hypertension: tip of the iceberg? |
| title_fullStr | Harnessing the power of genomics in hypertension: tip of the iceberg? |
| title_full_unstemmed | Harnessing the power of genomics in hypertension: tip of the iceberg? |
| title_short | Harnessing the power of genomics in hypertension: tip of the iceberg? |
| title_sort | harnessing the power of genomics in hypertension tip of the iceberg |
| topic | hypertension precision medicine genomics |
| url | https://www.cambridge.org/core/product/identifier/S2752614325000018/type/journal_article |
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