Disulfiram suppresses growth of the malignant pleural mesothelioma cells in part by inducing apoptosis.

Disulfiram suppresses growth of the malignant pleural mesothelioma cells in part by inducing apoptosis.

Dithiocarbamate compound Disulfiram (DSF) that binds with copper and functions as an inhibitor of aldehyde dehydrogenase is a Food and Drug Administration approved agent for treatment of alcoholism. Copper complexed DSF (DSF-Cu) also possesses anti-tumor and chemosensitizing properties; however, its...

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Main Authors: Vino T Cheriyan, Ying Wang, Magesh Muthu, Shazia Jamal, Di Chen, Huanjie Yang, Lisa A Polin, Adi L Tarca, Harvey I Pass, Q Ping Dou, Sunita Sharma, Anil Wali, Arun K Rishi
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-01-01
Series:PLoS ONE
Online Access:https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0093711&type=printable
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