SIRT1 Mediates Neuropathic Pain Induced by Sciatic Nerve Chronic Constrictive Injury in the VTA-NAc Pathway

SIRT1 Mediates Neuropathic Pain Induced by Sciatic Nerve Chronic Constrictive Injury in the VTA-NAc Pathway

Background. Mounting evidence has shown that sirtuin 1 (SIRT1), a class III histone deacetylase, alleviated several types of neuropathic pain in the spinal cord and dorsal root ganglion and regulated some aberrant behaviors in the ventral tegmental area (VTA) and the nucleus accumbens (NAc). Methods...

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Bibliographic Details
Main Authors: Yangyang Li, Lei Wang, Guotao Zhang, Xueli Qiao, Mingxing Zhang
Format: Article
Language:English
Published: Wiley 2020-01-01
Series:Pain Research and Management
Online Access:http://dx.doi.org/10.1155/2020/4245968
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