Pharmacokinetics of dimeric dipeptide mimetic of nerve growth factor GC-2 in rats. Part 1. Single and multiple intravascular and extravascular administration. Testing the hypothesis of linearity of pharmacokinetics
The pharmacokinetics of dimeric dipeptide mimetic of nerve growth factor GC-2 in the rat blood plasma after different routes of administration was studied. The drug was administered at dose of 150 mg/kg by single and repeatedly. After single intravenous and intraperitoneal injection, GC-2 was detecte...
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| Format: | Article |
| Language: | Russian |
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LLC “Publisher OKI”
2023-11-01
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| Series: | Фармакокинетика и Фармакодинамика |
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| Online Access: | https://www.pharmacokinetica.ru/jour/article/view/377 |
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| author | O. Yu. Kravtsova O. G. Gribakina G. B. Kolyvanov A. A. Litvin P. O. Bochkov P. Yu. Povarnina V. P. Zherdev |
| author_facet | O. Yu. Kravtsova O. G. Gribakina G. B. Kolyvanov A. A. Litvin P. O. Bochkov P. Yu. Povarnina V. P. Zherdev |
| author_sort | O. Yu. Kravtsova |
| collection | DOAJ |
| description | The pharmacokinetics of dimeric dipeptide mimetic of nerve growth factor GC-2 in the rat blood plasma after different routes of administration was studied. The drug was administered at dose of 150 mg/kg by single and repeatedly. After single intravenous and intraperitoneal injection, GC-2 was detected for 2 h, its half-life was 0.4 h. GC-2 absolute bioavailability after single intraperitoneal injection was 84.62 %, that indicates the prospect of development its injectable (intramuscularly) dosage form. After 4-fold (1.5 h dosing interval) intraperitoneal injection dose-independent pharmacokinetic parameters of GC-2 practically do not change compared to single administration. This indicates that GC-2 is not accumulated in the body of rats. The hypothesis of the linearity of the pharmacokinetics of GC-2 in the rats blood plasma after single intraperitoneal administration at doses of 50, 100 and 150 mg/kg was tested. It was found that the kinetics of GC-2 in the rat blood plasma is linea. |
| format | Article |
| id | doaj-art-e8c497f291f7473f9c19ee94ffb123e4 |
| institution | Kabale University |
| issn | 2587-7836 2686-8830 |
| language | Russian |
| publishDate | 2023-11-01 |
| publisher | LLC “Publisher OKI” |
| record_format | Article |
| series | Фармакокинетика и Фармакодинамика |
| spelling | doaj-art-e8c497f291f7473f9c19ee94ffb123e42025-08-20T03:42:33ZrusLLC “Publisher OKI”Фармакокинетика и Фармакодинамика2587-78362686-88302023-11-0103121810.37489/2587-7836-2023-3-12-18340Pharmacokinetics of dimeric dipeptide mimetic of nerve growth factor GC-2 in rats. Part 1. Single and multiple intravascular and extravascular administration. Testing the hypothesis of linearity of pharmacokineticsO. Yu. Kravtsova0O. G. Gribakina1G. B. Kolyvanov2A. A. Litvin3P. O. Bochkov4P. Yu. Povarnina5V. P. Zherdev6FSBI “Research Zakusov Institue of Pharmacology”FSBI “Research Zakusov Institue of Pharmacology”FSBI “Research Zakusov Institue of Pharmacology”FSBI “Research Zakusov Institue of Pharmacology”FSBI “Research Zakusov Institue of Pharmacology”FSBI “Research Zakusov Institue of Pharmacology”FSBI “Research Zakusov Institue of Pharmacology”The pharmacokinetics of dimeric dipeptide mimetic of nerve growth factor GC-2 in the rat blood plasma after different routes of administration was studied. The drug was administered at dose of 150 mg/kg by single and repeatedly. After single intravenous and intraperitoneal injection, GC-2 was detected for 2 h, its half-life was 0.4 h. GC-2 absolute bioavailability after single intraperitoneal injection was 84.62 %, that indicates the prospect of development its injectable (intramuscularly) dosage form. After 4-fold (1.5 h dosing interval) intraperitoneal injection dose-independent pharmacokinetic parameters of GC-2 practically do not change compared to single administration. This indicates that GC-2 is not accumulated in the body of rats. The hypothesis of the linearity of the pharmacokinetics of GC-2 in the rats blood plasma after single intraperitoneal administration at doses of 50, 100 and 150 mg/kg was tested. It was found that the kinetics of GC-2 in the rat blood plasma is linea.https://www.pharmacokinetica.ru/jour/article/view/377nerve growth factordimeric dipeptide mimetic gk-2preclinical pharmacokineticsabsolute bioavailabilitylinearity of kinetics |
| spellingShingle | O. Yu. Kravtsova O. G. Gribakina G. B. Kolyvanov A. A. Litvin P. O. Bochkov P. Yu. Povarnina V. P. Zherdev Pharmacokinetics of dimeric dipeptide mimetic of nerve growth factor GC-2 in rats. Part 1. Single and multiple intravascular and extravascular administration. Testing the hypothesis of linearity of pharmacokinetics Фармакокинетика и Фармакодинамика nerve growth factor dimeric dipeptide mimetic gk-2 preclinical pharmacokinetics absolute bioavailability linearity of kinetics |
| title | Pharmacokinetics of dimeric dipeptide mimetic of nerve growth factor GC-2 in rats. Part 1. Single and multiple intravascular and extravascular administration. Testing the hypothesis of linearity of pharmacokinetics |
| title_full | Pharmacokinetics of dimeric dipeptide mimetic of nerve growth factor GC-2 in rats. Part 1. Single and multiple intravascular and extravascular administration. Testing the hypothesis of linearity of pharmacokinetics |
| title_fullStr | Pharmacokinetics of dimeric dipeptide mimetic of nerve growth factor GC-2 in rats. Part 1. Single and multiple intravascular and extravascular administration. Testing the hypothesis of linearity of pharmacokinetics |
| title_full_unstemmed | Pharmacokinetics of dimeric dipeptide mimetic of nerve growth factor GC-2 in rats. Part 1. Single and multiple intravascular and extravascular administration. Testing the hypothesis of linearity of pharmacokinetics |
| title_short | Pharmacokinetics of dimeric dipeptide mimetic of nerve growth factor GC-2 in rats. Part 1. Single and multiple intravascular and extravascular administration. Testing the hypothesis of linearity of pharmacokinetics |
| title_sort | pharmacokinetics of dimeric dipeptide mimetic of nerve growth factor gc 2 in rats part 1 single and multiple intravascular and extravascular administration testing the hypothesis of linearity of pharmacokinetics |
| topic | nerve growth factor dimeric dipeptide mimetic gk-2 preclinical pharmacokinetics absolute bioavailability linearity of kinetics |
| url | https://www.pharmacokinetica.ru/jour/article/view/377 |
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