Pathology and diagnostic approaches to well-differentiated hepatocellular lesions: a narrative review
Well-differentiated hepatocellular lesions (WDHLs) are liver tumors or nonneoplastic lesions in which the cells closely resemble normal hepatocytes. These lesions often include focal nodular hyperplasia, hepatocellular adenoma, macroregenerative nodule, dysplastic nodule, and well-differentiated hep...
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| Format: | Article |
| Language: | English |
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Yeungnam University College of Medicine, Yeungnam University Institute Medical Science
2025-01-01
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| Series: | Journal of Yeungnam Medical Science |
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| Online Access: | http://www.e-jyms.org/upload/pdf/jyms-2024-00766.pdf |
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| author | Joon Hyuk Choi Swan N. Thung |
| author_facet | Joon Hyuk Choi Swan N. Thung |
| author_sort | Joon Hyuk Choi |
| collection | DOAJ |
| description | Well-differentiated hepatocellular lesions (WDHLs) are liver tumors or nonneoplastic lesions in which the cells closely resemble normal hepatocytes. These lesions often include focal nodular hyperplasia, hepatocellular adenoma, macroregenerative nodule, dysplastic nodule, and well-differentiated hepatocellular carcinoma. The diagnosis of these lesions remains challenging because of their morphological similarities, particularly when examined using needle biopsy. The accurate diagnosis of WDHLs is crucial for patient management and prognosis. This review addresses the histopathological characteristics and diagnostic approaches of WDHLs. |
| format | Article |
| id | doaj-art-e8c40f30f1a546528d16d44255b0973e |
| institution | Kabale University |
| issn | 2799-8010 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Yeungnam University College of Medicine, Yeungnam University Institute Medical Science |
| record_format | Article |
| series | Journal of Yeungnam Medical Science |
| spelling | doaj-art-e8c40f30f1a546528d16d44255b0973e2025-02-11T06:26:37ZengYeungnam University College of Medicine, Yeungnam University Institute Medical ScienceJournal of Yeungnam Medical Science2799-80102025-01-014210.12701/jyms.2024.007662864Pathology and diagnostic approaches to well-differentiated hepatocellular lesions: a narrative reviewJoon Hyuk Choi0Swan N. Thung1 Department of Pathology, Yeungnam University College of Medicine, Daegu, Korea Department of Pathology, Molecular and Cell-Based Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USAWell-differentiated hepatocellular lesions (WDHLs) are liver tumors or nonneoplastic lesions in which the cells closely resemble normal hepatocytes. These lesions often include focal nodular hyperplasia, hepatocellular adenoma, macroregenerative nodule, dysplastic nodule, and well-differentiated hepatocellular carcinoma. The diagnosis of these lesions remains challenging because of their morphological similarities, particularly when examined using needle biopsy. The accurate diagnosis of WDHLs is crucial for patient management and prognosis. This review addresses the histopathological characteristics and diagnostic approaches of WDHLs.http://www.e-jyms.org/upload/pdf/jyms-2024-00766.pdffocal nodular hyperplasiahepatocellular adenomahepatocellular carcinomaliverpathology |
| spellingShingle | Joon Hyuk Choi Swan N. Thung Pathology and diagnostic approaches to well-differentiated hepatocellular lesions: a narrative review Journal of Yeungnam Medical Science focal nodular hyperplasia hepatocellular adenoma hepatocellular carcinoma liver pathology |
| title | Pathology and diagnostic approaches to well-differentiated hepatocellular lesions: a narrative review |
| title_full | Pathology and diagnostic approaches to well-differentiated hepatocellular lesions: a narrative review |
| title_fullStr | Pathology and diagnostic approaches to well-differentiated hepatocellular lesions: a narrative review |
| title_full_unstemmed | Pathology and diagnostic approaches to well-differentiated hepatocellular lesions: a narrative review |
| title_short | Pathology and diagnostic approaches to well-differentiated hepatocellular lesions: a narrative review |
| title_sort | pathology and diagnostic approaches to well differentiated hepatocellular lesions a narrative review |
| topic | focal nodular hyperplasia hepatocellular adenoma hepatocellular carcinoma liver pathology |
| url | http://www.e-jyms.org/upload/pdf/jyms-2024-00766.pdf |
| work_keys_str_mv | AT joonhyukchoi pathologyanddiagnosticapproachestowelldifferentiatedhepatocellularlesionsanarrativereview AT swannthung pathologyanddiagnosticapproachestowelldifferentiatedhepatocellularlesionsanarrativereview |