Continuous Multimodality Monitoring in Children after Traumatic Brain Injury-Preliminary Experience.
<h4>Introduction</h4>Multimodality monitoring is regularly employed in adult traumatic brain injury (TBI) patients where it provides physiologic and therapeutic insight into this heterogeneous condition. Pediatric studies are less frequent.<h4>Methods</h4>An analysis of data...
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Public Library of Science (PLoS)
2016-01-01
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| Series: | PLoS ONE |
| Online Access: | https://doi.org/10.1371/journal.pone.0148817 |
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| author | Adam M H Young Joseph Donnelly Marek Czosnyka Ibrahim Jalloh Xiuyun Liu Marcel J Aries Helen M Fernandes Matthew R Garnett Peter Smielewski Peter J Hutchinson Shruti Agrawal |
| author_facet | Adam M H Young Joseph Donnelly Marek Czosnyka Ibrahim Jalloh Xiuyun Liu Marcel J Aries Helen M Fernandes Matthew R Garnett Peter Smielewski Peter J Hutchinson Shruti Agrawal |
| author_sort | Adam M H Young |
| collection | DOAJ |
| description | <h4>Introduction</h4>Multimodality monitoring is regularly employed in adult traumatic brain injury (TBI) patients where it provides physiologic and therapeutic insight into this heterogeneous condition. Pediatric studies are less frequent.<h4>Methods</h4>An analysis of data collected prospectively from 12 pediatric TBI patients admitted to Addenbrooke's Hospital, Pediatric Intensive Care Unit (PICU) between August 2012 and December 2014 was performed. Patients' intracranial pressure (ICP), mean arterial pressure (MAP), and cerebral perfusion pressure (CPP) were monitored continuously using brain monitoring software ICM+®,) Pressure reactivity index (PRx) and 'Optimal CPP' (CPPopt) were calculated. Patient outcome was dichotomized into survivors and non-survivors.<h4>Results</h4>At 6 months 8/12 (66%) of the cohort survived the TBI. The median (±IQR) ICP was significantly lower in survivors 13.1±3.2 mm Hg compared to non-survivors 21.6±42.9 mm Hg (p = 0.003). The median time spent with ICP over 20 mm Hg was lower in survivors (9.7+9.8% vs 60.5+67.4% in non-survivors; p = 0.003). Although there was no evidence that CPP was different between survival groups, the time spent with a CPP close (within 10 mm Hg) to the optimal CPP was significantly longer in survivors (90.7±12.6%) compared with non-survivors (70.6±21.8%; p = 0.02). PRx provided significant outcome separation with median PRx in survivors being 0.02±0.19 compared to 0.39±0.62 in non-survivors (p = 0.02).<h4>Conclusion</h4>Our observations provide evidence that multi-modality monitoring may be useful in pediatric TBI with ICP, deviation of CPP from CPPopt, and PRx correlating with patient outcome. |
| format | Article |
| id | doaj-art-e8c32b63bdf14c91a3e624f1ea5f288c |
| institution | OA Journals |
| issn | 1932-6203 |
| language | English |
| publishDate | 2016-01-01 |
| publisher | Public Library of Science (PLoS) |
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| series | PLoS ONE |
| spelling | doaj-art-e8c32b63bdf14c91a3e624f1ea5f288c2025-08-20T02:34:12ZengPublic Library of Science (PLoS)PLoS ONE1932-62032016-01-01113e014881710.1371/journal.pone.0148817Continuous Multimodality Monitoring in Children after Traumatic Brain Injury-Preliminary Experience.Adam M H YoungJoseph DonnellyMarek CzosnykaIbrahim JallohXiuyun LiuMarcel J AriesHelen M FernandesMatthew R GarnettPeter SmielewskiPeter J HutchinsonShruti Agrawal<h4>Introduction</h4>Multimodality monitoring is regularly employed in adult traumatic brain injury (TBI) patients where it provides physiologic and therapeutic insight into this heterogeneous condition. Pediatric studies are less frequent.<h4>Methods</h4>An analysis of data collected prospectively from 12 pediatric TBI patients admitted to Addenbrooke's Hospital, Pediatric Intensive Care Unit (PICU) between August 2012 and December 2014 was performed. Patients' intracranial pressure (ICP), mean arterial pressure (MAP), and cerebral perfusion pressure (CPP) were monitored continuously using brain monitoring software ICM+®,) Pressure reactivity index (PRx) and 'Optimal CPP' (CPPopt) were calculated. Patient outcome was dichotomized into survivors and non-survivors.<h4>Results</h4>At 6 months 8/12 (66%) of the cohort survived the TBI. The median (±IQR) ICP was significantly lower in survivors 13.1±3.2 mm Hg compared to non-survivors 21.6±42.9 mm Hg (p = 0.003). The median time spent with ICP over 20 mm Hg was lower in survivors (9.7+9.8% vs 60.5+67.4% in non-survivors; p = 0.003). Although there was no evidence that CPP was different between survival groups, the time spent with a CPP close (within 10 mm Hg) to the optimal CPP was significantly longer in survivors (90.7±12.6%) compared with non-survivors (70.6±21.8%; p = 0.02). PRx provided significant outcome separation with median PRx in survivors being 0.02±0.19 compared to 0.39±0.62 in non-survivors (p = 0.02).<h4>Conclusion</h4>Our observations provide evidence that multi-modality monitoring may be useful in pediatric TBI with ICP, deviation of CPP from CPPopt, and PRx correlating with patient outcome.https://doi.org/10.1371/journal.pone.0148817 |
| spellingShingle | Adam M H Young Joseph Donnelly Marek Czosnyka Ibrahim Jalloh Xiuyun Liu Marcel J Aries Helen M Fernandes Matthew R Garnett Peter Smielewski Peter J Hutchinson Shruti Agrawal Continuous Multimodality Monitoring in Children after Traumatic Brain Injury-Preliminary Experience. PLoS ONE |
| title | Continuous Multimodality Monitoring in Children after Traumatic Brain Injury-Preliminary Experience. |
| title_full | Continuous Multimodality Monitoring in Children after Traumatic Brain Injury-Preliminary Experience. |
| title_fullStr | Continuous Multimodality Monitoring in Children after Traumatic Brain Injury-Preliminary Experience. |
| title_full_unstemmed | Continuous Multimodality Monitoring in Children after Traumatic Brain Injury-Preliminary Experience. |
| title_short | Continuous Multimodality Monitoring in Children after Traumatic Brain Injury-Preliminary Experience. |
| title_sort | continuous multimodality monitoring in children after traumatic brain injury preliminary experience |
| url | https://doi.org/10.1371/journal.pone.0148817 |
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