Priming VRC01-precursor B cells with non-envelope immunogens disfavors boosting with HIV-1 envelope

Priming VRC01-precursor B cells with non-envelope immunogens disfavors boosting with HIV-1 envelope

Abstract VRC01-class antibodies are a genetically restricted class of antibodies capable of potently neutralizing diverse strains of HIV-1. Unmutated VRC01 precursors fail to recognize recombinant HIV-1 Envelope (Env) proteins, which necessitated the development of germline targeting vaccine immunog...

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Main Authors: Andrew Wilcox-King, Yu-Hsin Wan, Samuel C. Scharffenberger, Crystal B. Chhan, Amelia R. Davis, Leah J. Homad, Emilie Seydoux, Kellie J. MacPhee, Latha Kallur Siddaramaiah, Mariane Melo, Pia Dosenovic, Darrell J. Irvine, Ollivier Hyrien, Leonidas Stamatatos, Andrew T. McGuire
Format: Article
Language:English
Published: Nature Portfolio 2025-08-01
Series:npj Vaccines
Online Access:https://doi.org/10.1038/s41541-025-01235-5
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