Highly conserved ion binding sites are not all functionally relevant in mouse KCC4

Highly conserved ion binding sites are not all functionally relevant in mouse KCC4

IntroductionThe potassium chloride cotransporter 4 (KCC4) is expressed in various tissues and plays an important role in distal renal acidification and hearing development. Although KCCs transport K+ and Cl− in a 1:1 stoichiometry, two Cl− coordination sites were indicated via cryo-electron microsco...

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Bibliographic Details
Main Authors: Lisa Becker, Jens Hausmann, Rieke Wellpott, Anna-Maria Hartmann
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-03-01
Series:Frontiers in Molecular Biosciences
Subjects:
KCC
large extracellular loop
site directed mutagenesis
protein conformation
ion binding sites
Online Access:https://www.frontiersin.org/articles/10.3389/fmolb.2025.1556250/full
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