Preparation, in vitro release and antibacterial activity evaluation of rifampicin and moxifloxacin-loaded poly(D,L-lactide-co-glycolide) microspheres

Preparation, in vitro release and antibacterial activity evaluation of rifampicin and moxifloxacin-loaded poly(D,L-lactide-co-glycolide) microspheres

Osteomyelitis is difficult to treat because infective bone is poorly accessible for intravenously administering antibiotics and biofilm formation increases bacterial resistance. In this study, microspheres prepared using poly(lactide-co-glycolide) (PLGA) and embedded with moxifloxacin (MOX–PLGA micr...

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Bibliographic Details
Main Authors: ZeWen Qiao, Zhi Yuan, Wenping Zhang, Daihao Wei, Ningmin Hu
Format: Article
Language:English
Published: Taylor & Francis Group 2019-12-01
Series:Artificial Cells, Nanomedicine, and Biotechnology
Subjects:
Bacterial biofilm
osteomyelitis
PLGA microspheres
moxifloxacin
rifampicin
Online Access:https://www.tandfonline.com/doi/10.1080/21691401.2019.1581792
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https://www.tandfonline.com/doi/10.1080/21691401.2019.1581792

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