Subcellular Organelle Targeting as a Novel Approach to Combat Tumor Metastasis
Tumor metastasis, the spread of cancer cells from the primary site to distant organs, remains a formidable challenge in oncology. Central to this process is the involvement of subcellular organelles, which undergo significant functional and structural changes during metastasis. Targeting these speci...
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| Format: | Article |
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MDPI AG
2025-02-01
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| Series: | Pharmaceutics |
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| Online Access: | https://www.mdpi.com/1999-4923/17/2/198 |
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| author | Zefan Liu Yang Liu Xin Kang Lian Li Yucheng Xiang |
| author_facet | Zefan Liu Yang Liu Xin Kang Lian Li Yucheng Xiang |
| author_sort | Zefan Liu |
| collection | DOAJ |
| description | Tumor metastasis, the spread of cancer cells from the primary site to distant organs, remains a formidable challenge in oncology. Central to this process is the involvement of subcellular organelles, which undergo significant functional and structural changes during metastasis. Targeting these specific organelles offers a promising avenue for enhanced drug delivery and metastasis therapeutic efficacy. This precision increases the potency and reduces potential off-target effects. Moreover, by understanding the role of each organelle in metastasis, treatments can be designed to disrupt the metastatic process at multiple stages, from cell migration to the establishment of secondary tumors. This review delves deeply into tumor metastasis processes and their connection with subcellular organelles. In order to target these organelles, biomembranes, cell-penetrating peptides, localization signal peptides, aptamers, specific small molecules, and various other strategies have been developed. In this review, we will elucidate targeting delivery strategies for each subcellular organelle and look forward to prospects in this domain. |
| format | Article |
| id | doaj-art-e8b4587655dd4f2b909682c830f658d6 |
| institution | OA Journals |
| issn | 1999-4923 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Pharmaceutics |
| spelling | doaj-art-e8b4587655dd4f2b909682c830f658d62025-08-20T02:03:42ZengMDPI AGPharmaceutics1999-49232025-02-0117219810.3390/pharmaceutics17020198Subcellular Organelle Targeting as a Novel Approach to Combat Tumor MetastasisZefan Liu0Yang Liu1Xin Kang2Lian Li3Yucheng Xiang4Department of General Surgery, First People‘s Hospital of Shuangliu District (West China Airport Hospital of Sichuan University), Chengdu 610200, ChinaDepartment of General Surgery, First People‘s Hospital of Shuangliu District (West China Airport Hospital of Sichuan University), Chengdu 610200, ChinaDepartment of General Surgery, First People‘s Hospital of Shuangliu District (West China Airport Hospital of Sichuan University), Chengdu 610200, ChinaKey Laboratory of Drug-Targeting and Drug Delivery System of the Education Ministry and Sichuan Province, Sichuan Engineering Laboratory for Plant-Sourced Drug and Sichuan Research Center for Drug Precision Industrial Technology, West China School of Pharmacy, Sichuan University, Chengdu 610041, ChinaSchool of Pharmacy, Chengdu Medical College, Chengdu 610500, ChinaTumor metastasis, the spread of cancer cells from the primary site to distant organs, remains a formidable challenge in oncology. Central to this process is the involvement of subcellular organelles, which undergo significant functional and structural changes during metastasis. Targeting these specific organelles offers a promising avenue for enhanced drug delivery and metastasis therapeutic efficacy. This precision increases the potency and reduces potential off-target effects. Moreover, by understanding the role of each organelle in metastasis, treatments can be designed to disrupt the metastatic process at multiple stages, from cell migration to the establishment of secondary tumors. This review delves deeply into tumor metastasis processes and their connection with subcellular organelles. In order to target these organelles, biomembranes, cell-penetrating peptides, localization signal peptides, aptamers, specific small molecules, and various other strategies have been developed. In this review, we will elucidate targeting delivery strategies for each subcellular organelle and look forward to prospects in this domain.https://www.mdpi.com/1999-4923/17/2/198tumor metastasistargeted therapysubcellular organelles |
| spellingShingle | Zefan Liu Yang Liu Xin Kang Lian Li Yucheng Xiang Subcellular Organelle Targeting as a Novel Approach to Combat Tumor Metastasis Pharmaceutics tumor metastasis targeted therapy subcellular organelles |
| title | Subcellular Organelle Targeting as a Novel Approach to Combat Tumor Metastasis |
| title_full | Subcellular Organelle Targeting as a Novel Approach to Combat Tumor Metastasis |
| title_fullStr | Subcellular Organelle Targeting as a Novel Approach to Combat Tumor Metastasis |
| title_full_unstemmed | Subcellular Organelle Targeting as a Novel Approach to Combat Tumor Metastasis |
| title_short | Subcellular Organelle Targeting as a Novel Approach to Combat Tumor Metastasis |
| title_sort | subcellular organelle targeting as a novel approach to combat tumor metastasis |
| topic | tumor metastasis targeted therapy subcellular organelles |
| url | https://www.mdpi.com/1999-4923/17/2/198 |
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