Histidine triad nucleotide-binding protein 2 attenuates metabolic dysfunction-associated steatotic liver disease through NAD+-dependent sirtuin-3 activation

Histidine triad nucleotide-binding protein 2 attenuates metabolic dysfunction-associated steatotic liver disease through NAD+-dependent sirtuin-3 activation

Abstract Metabolic dysfunction-associated steatotic liver disease (MASLD) is the most common chronic liver disease, but its pathogenesis is unclear. Here we focus on histidine triad nucleotide-binding protein 2 (HINT2), which is expressed in the mitochondria and is involved in hepatic lipid metaboli...

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Main Authors: Qinqiu Wang, Yanjun Guo, Shenghui Chen, Zhening Liu, Xinyu Wang, Hangkai Huang, Qi-en Shen, Ling Yang, Meng Li, Youming Li, Chaohui Yu, Chengfu Xu
Format: Article
Language:English
Published: Nature Publishing Group 2025-05-01
Series:Experimental and Molecular Medicine
Online Access:https://doi.org/10.1038/s12276-025-01445-w
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