Distinct role of primate DLPFC and LIP in hierarchical control of learned saccade sequences
Summary: Learned action sequences are suggested to be organized hierarchically, but how the various hierarchical levels are processed by different cortical regions remains largely unknown. By training monkeys to perform heterogeneous saccade sequences, we investigated the role of the dorsolateral pr...
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| Language: | English |
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Elsevier
2025-01-01
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| Series: | iScience |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2589004224029213 |
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| author | Qingjun Wang Binchao Shi Jing Jia Jingyu Hu Haoran Li Xin Jin Aihua Chen |
| author_facet | Qingjun Wang Binchao Shi Jing Jia Jingyu Hu Haoran Li Xin Jin Aihua Chen |
| author_sort | Qingjun Wang |
| collection | DOAJ |
| description | Summary: Learned action sequences are suggested to be organized hierarchically, but how the various hierarchical levels are processed by different cortical regions remains largely unknown. By training monkeys to perform heterogeneous saccade sequences, we investigated the role of the dorsolateral prefrontal cortex (DLPFC) and the lateral intraparietal cortex (LIP) in sequence planning and execution. The electrophysiological recording revealed that sequence-level initiation information was mostly signaled by DLPFC neurons, whereas subsequence-level transition was largely encoded by LIP neurons. Although electrical microstimulation on DLPFC weakly affected sequence performance, inactivating DLPFC significantly increased the initiation latency of the entire sequences, indicating that DLPFC was involved in the sequence initiation. In contrast, either microstimulation or inactivation of area LIP caused improper switches between subsequences, suggesting that LIP played a role in subsequence switch. Overall, these results demonstrated that frontal and parietal cortices play distinct yet complementary roles in controlling learned saccade sequences. |
| format | Article |
| id | doaj-art-e8b3488a107548f8a66eb667552040f2 |
| institution | OA Journals |
| issn | 2589-0042 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | iScience |
| spelling | doaj-art-e8b3488a107548f8a66eb667552040f22025-08-20T02:37:28ZengElsevieriScience2589-00422025-01-0128111169410.1016/j.isci.2024.111694Distinct role of primate DLPFC and LIP in hierarchical control of learned saccade sequencesQingjun Wang0Binchao Shi1Jing Jia2Jingyu Hu3Haoran Li4Xin Jin5Aihua Chen6Key Laboratory of Brain Functional Genomics (Ministry of Education), East China Normal University, Shanghai 200062, ChinaKey Laboratory of Brain Functional Genomics (Ministry of Education), East China Normal University, Shanghai 200062, ChinaKey Laboratory of Brain Functional Genomics (Ministry of Education), East China Normal University, Shanghai 200062, ChinaKey Laboratory of Brain Functional Genomics (Ministry of Education), East China Normal University, Shanghai 200062, ChinaKey Laboratory of Brain Functional Genomics (Ministry of Education), East China Normal University, Shanghai 200062, ChinaKey Laboratory of Brain Functional Genomics (Ministry of Education), East China Normal University, Shanghai 200062, China; New Cornerstone Science Laboratory, Center for Motor Control and Disease, East China Normal University, Shanghai 200062, China; NYU-ECNU Institute of Brain and Cognitive Science, New York University Shanghai, Shanghai 200062, China; Corresponding authorKey Laboratory of Brain Functional Genomics (Ministry of Education), East China Normal University, Shanghai 200062, China; NYU-ECNU Institute of Brain and Cognitive Science, New York University Shanghai, Shanghai 200062, China; Corresponding authorSummary: Learned action sequences are suggested to be organized hierarchically, but how the various hierarchical levels are processed by different cortical regions remains largely unknown. By training monkeys to perform heterogeneous saccade sequences, we investigated the role of the dorsolateral prefrontal cortex (DLPFC) and the lateral intraparietal cortex (LIP) in sequence planning and execution. The electrophysiological recording revealed that sequence-level initiation information was mostly signaled by DLPFC neurons, whereas subsequence-level transition was largely encoded by LIP neurons. Although electrical microstimulation on DLPFC weakly affected sequence performance, inactivating DLPFC significantly increased the initiation latency of the entire sequences, indicating that DLPFC was involved in the sequence initiation. In contrast, either microstimulation or inactivation of area LIP caused improper switches between subsequences, suggesting that LIP played a role in subsequence switch. Overall, these results demonstrated that frontal and parietal cortices play distinct yet complementary roles in controlling learned saccade sequences.http://www.sciencedirect.com/science/article/pii/S2589004224029213Biological sciencesPhysiologyNeuroscience |
| spellingShingle | Qingjun Wang Binchao Shi Jing Jia Jingyu Hu Haoran Li Xin Jin Aihua Chen Distinct role of primate DLPFC and LIP in hierarchical control of learned saccade sequences iScience Biological sciences Physiology Neuroscience |
| title | Distinct role of primate DLPFC and LIP in hierarchical control of learned saccade sequences |
| title_full | Distinct role of primate DLPFC and LIP in hierarchical control of learned saccade sequences |
| title_fullStr | Distinct role of primate DLPFC and LIP in hierarchical control of learned saccade sequences |
| title_full_unstemmed | Distinct role of primate DLPFC and LIP in hierarchical control of learned saccade sequences |
| title_short | Distinct role of primate DLPFC and LIP in hierarchical control of learned saccade sequences |
| title_sort | distinct role of primate dlpfc and lip in hierarchical control of learned saccade sequences |
| topic | Biological sciences Physiology Neuroscience |
| url | http://www.sciencedirect.com/science/article/pii/S2589004224029213 |
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