ALA-PDT combined with 2940 nm ablative fractional Er:YAG laser for Darier's disease
Darier's disease is a rare, genetically determined dyskeratotic skin disorder. Although many conventional treatments have been reported, management of Darier's disease remains challenging. Most patients are at high risk of recurrence during long-term follow-up. Here, we present two patient...
Saved in:
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2024-02-01
|
| Series: | Photodiagnosis and Photodynamic Therapy |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S1572100023006191 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1850105428997832704 |
|---|---|
| author | Tingting Gao Junyan Xiao Na Pan Fan Xia Xianyu Zeng Li Qin |
| author_facet | Tingting Gao Junyan Xiao Na Pan Fan Xia Xianyu Zeng Li Qin |
| author_sort | Tingting Gao |
| collection | DOAJ |
| description | Darier's disease is a rare, genetically determined dyskeratotic skin disorder. Although many conventional treatments have been reported, management of Darier's disease remains challenging. Most patients are at high risk of recurrence during long-term follow-up. Here, we present two patients who were successfully treated with ALA photodynamic therapy (PDT) and ablative 2940 nm Er:YAG fractional laser. Both patients exhibited significant improvements in the affected areas with moderate pain, transient erythema and edema. Remission durations of up to 2 years were observed in both patients after combination treatment. Our findings suggest that the combination of ALA-PDT and 2940 nm fractional Er:YAG laser may be an effective, safe and well-tolerated treatment option for Darier's disease. |
| format | Article |
| id | doaj-art-e8ae4ab53b86415f8a77c3d6a7f7a765 |
| institution | OA Journals |
| issn | 1572-1000 |
| language | English |
| publishDate | 2024-02-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Photodiagnosis and Photodynamic Therapy |
| spelling | doaj-art-e8ae4ab53b86415f8a77c3d6a7f7a7652025-08-20T02:39:07ZengElsevierPhotodiagnosis and Photodynamic Therapy1572-10002024-02-014510389210.1016/j.pdpdt.2023.103892ALA-PDT combined with 2940 nm ablative fractional Er:YAG laser for Darier's diseaseTingting Gao0Junyan Xiao1Na Pan2Fan Xia3Xianyu Zeng4Li Qin5Department of Dermatology, Traditional Chinese and Western Medicine Hospital of Wuhan, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430022, China; Department of Dermatology, Wuhan No.1 Hospital, Wuhan, Hubei 430022, ChinaDepartment of Dermatology, Traditional Chinese and Western Medicine Hospital of Wuhan, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430022, China; Department of Dermatology, Wuhan No.1 Hospital, Wuhan, Hubei 430022, ChinaDepartment of Dermatology, Traditional Chinese and Western Medicine Hospital of Wuhan, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430022, China; Department of Dermatology, Wuhan No.1 Hospital, Wuhan, Hubei 430022, ChinaDepartment of Dermatology, Traditional Chinese and Western Medicine Hospital of Wuhan, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430022, China; Department of Dermatology, Wuhan No.1 Hospital, Wuhan, Hubei 430022, ChinaDepartment of Dermatology, Traditional Chinese and Western Medicine Hospital of Wuhan, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430022, China; Department of Dermatology, Wuhan No.1 Hospital, Wuhan, Hubei 430022, China; Corresponding authors at: Department of Dermatology, Traditional Chinese and Western Medicine Hospital of Wuhan, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430022, China.Department of Dermatology, Traditional Chinese and Western Medicine Hospital of Wuhan, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430022, China; Department of Dermatology, Wuhan No.1 Hospital, Wuhan, Hubei 430022, China; Corresponding authors at: Department of Dermatology, Traditional Chinese and Western Medicine Hospital of Wuhan, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430022, China.Darier's disease is a rare, genetically determined dyskeratotic skin disorder. Although many conventional treatments have been reported, management of Darier's disease remains challenging. Most patients are at high risk of recurrence during long-term follow-up. Here, we present two patients who were successfully treated with ALA photodynamic therapy (PDT) and ablative 2940 nm Er:YAG fractional laser. Both patients exhibited significant improvements in the affected areas with moderate pain, transient erythema and edema. Remission durations of up to 2 years were observed in both patients after combination treatment. Our findings suggest that the combination of ALA-PDT and 2940 nm fractional Er:YAG laser may be an effective, safe and well-tolerated treatment option for Darier's disease.http://www.sciencedirect.com/science/article/pii/S1572100023006191Photodynamic therapyDarier's diseaseLaserTreatmentALA |
| spellingShingle | Tingting Gao Junyan Xiao Na Pan Fan Xia Xianyu Zeng Li Qin ALA-PDT combined with 2940 nm ablative fractional Er:YAG laser for Darier's disease Photodiagnosis and Photodynamic Therapy Photodynamic therapy Darier's disease Laser Treatment ALA |
| title | ALA-PDT combined with 2940 nm ablative fractional Er:YAG laser for Darier's disease |
| title_full | ALA-PDT combined with 2940 nm ablative fractional Er:YAG laser for Darier's disease |
| title_fullStr | ALA-PDT combined with 2940 nm ablative fractional Er:YAG laser for Darier's disease |
| title_full_unstemmed | ALA-PDT combined with 2940 nm ablative fractional Er:YAG laser for Darier's disease |
| title_short | ALA-PDT combined with 2940 nm ablative fractional Er:YAG laser for Darier's disease |
| title_sort | ala pdt combined with 2940 nm ablative fractional er yag laser for darier s disease |
| topic | Photodynamic therapy Darier's disease Laser Treatment ALA |
| url | http://www.sciencedirect.com/science/article/pii/S1572100023006191 |
| work_keys_str_mv | AT tingtinggao alapdtcombinedwith2940nmablativefractionaleryaglaserfordariersdisease AT junyanxiao alapdtcombinedwith2940nmablativefractionaleryaglaserfordariersdisease AT napan alapdtcombinedwith2940nmablativefractionaleryaglaserfordariersdisease AT fanxia alapdtcombinedwith2940nmablativefractionaleryaglaserfordariersdisease AT xianyuzeng alapdtcombinedwith2940nmablativefractionaleryaglaserfordariersdisease AT liqin alapdtcombinedwith2940nmablativefractionaleryaglaserfordariersdisease |