In Elderly Patients With Antipsychotic-Induced Hyperprolactinemia, Could Switching to a Prolactin-Sparing Antipsychotic or Adding a Dopamine Agonist, Rather Than Maintaining the Current Regimen, Normalize the Prolactin Levels Without Triggering Psychotic Relapse or Increasing the Risk of Life-Threatening Adverse Events? A Systematic Review
Aims: Elevated prolactin levels due to antipsychotic drugs are prevalent in elderly patients and may cause multiple complications. Hence, the purpose of the present study is to compare the effectiveness of changing existing antipsychotic treatments with prolactin-sparing antipsychotics or adding dop...
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| Format: | Article |
| Language: | English |
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Cambridge University Press
2025-06-01
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| Series: | BJPsych Open |
| Online Access: | https://www.cambridge.org/core/product/identifier/S2056472425102366/type/journal_article |
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| author | Gaurav Uppal Sathyan Soundara Rajan Akhila Bhandarkar Sneh Babhulkar Asha Devi Dhandapani |
| author_facet | Gaurav Uppal Sathyan Soundara Rajan Akhila Bhandarkar Sneh Babhulkar Asha Devi Dhandapani |
| author_sort | Gaurav Uppal |
| collection | DOAJ |
| description | Aims: Elevated prolactin levels due to antipsychotic drugs are prevalent in elderly patients and may cause multiple complications. Hence, the purpose of the present study is to compare the effectiveness of changing existing antipsychotic treatments with prolactin-sparing antipsychotics or adding dopaminergic agents to the existing treatment in patients with clinically insignificant hyperprolactinaemia in later life. |
| format | Article |
| id | doaj-art-e8aca0797f2f4833944fe148f6dec2b0 |
| institution | DOAJ |
| issn | 2056-4724 |
| language | English |
| publishDate | 2025-06-01 |
| publisher | Cambridge University Press |
| record_format | Article |
| series | BJPsych Open |
| spelling | doaj-art-e8aca0797f2f4833944fe148f6dec2b02025-08-20T02:50:55ZengCambridge University PressBJPsych Open2056-47242025-06-0111S72S7210.1192/bjo.2025.10236In Elderly Patients With Antipsychotic-Induced Hyperprolactinemia, Could Switching to a Prolactin-Sparing Antipsychotic or Adding a Dopamine Agonist, Rather Than Maintaining the Current Regimen, Normalize the Prolactin Levels Without Triggering Psychotic Relapse or Increasing the Risk of Life-Threatening Adverse Events? A Systematic ReviewGaurav Uppal0Sathyan Soundara Rajan1Akhila Bhandarkar2Sneh Babhulkar3Asha Devi Dhandapani4Satyam Hospital, Ludhiana, IndiaBCUHB, Wrexham, United KingdomKSHEMA, Mangalore, IndiaGreater Glasgow and Clyde NHS Trust, Glasgow, United KingdomBCUHB, Wrexham, United KingdomAims: Elevated prolactin levels due to antipsychotic drugs are prevalent in elderly patients and may cause multiple complications. Hence, the purpose of the present study is to compare the effectiveness of changing existing antipsychotic treatments with prolactin-sparing antipsychotics or adding dopaminergic agents to the existing treatment in patients with clinically insignificant hyperprolactinaemia in later life.https://www.cambridge.org/core/product/identifier/S2056472425102366/type/journal_article |
| spellingShingle | Gaurav Uppal Sathyan Soundara Rajan Akhila Bhandarkar Sneh Babhulkar Asha Devi Dhandapani In Elderly Patients With Antipsychotic-Induced Hyperprolactinemia, Could Switching to a Prolactin-Sparing Antipsychotic or Adding a Dopamine Agonist, Rather Than Maintaining the Current Regimen, Normalize the Prolactin Levels Without Triggering Psychotic Relapse or Increasing the Risk of Life-Threatening Adverse Events? A Systematic Review BJPsych Open |
| title | In Elderly Patients With Antipsychotic-Induced Hyperprolactinemia, Could Switching to a Prolactin-Sparing Antipsychotic or Adding a Dopamine Agonist, Rather Than Maintaining the Current Regimen, Normalize the Prolactin Levels Without Triggering Psychotic Relapse or Increasing the Risk of Life-Threatening Adverse Events? A Systematic Review |
| title_full | In Elderly Patients With Antipsychotic-Induced Hyperprolactinemia, Could Switching to a Prolactin-Sparing Antipsychotic or Adding a Dopamine Agonist, Rather Than Maintaining the Current Regimen, Normalize the Prolactin Levels Without Triggering Psychotic Relapse or Increasing the Risk of Life-Threatening Adverse Events? A Systematic Review |
| title_fullStr | In Elderly Patients With Antipsychotic-Induced Hyperprolactinemia, Could Switching to a Prolactin-Sparing Antipsychotic or Adding a Dopamine Agonist, Rather Than Maintaining the Current Regimen, Normalize the Prolactin Levels Without Triggering Psychotic Relapse or Increasing the Risk of Life-Threatening Adverse Events? A Systematic Review |
| title_full_unstemmed | In Elderly Patients With Antipsychotic-Induced Hyperprolactinemia, Could Switching to a Prolactin-Sparing Antipsychotic or Adding a Dopamine Agonist, Rather Than Maintaining the Current Regimen, Normalize the Prolactin Levels Without Triggering Psychotic Relapse or Increasing the Risk of Life-Threatening Adverse Events? A Systematic Review |
| title_short | In Elderly Patients With Antipsychotic-Induced Hyperprolactinemia, Could Switching to a Prolactin-Sparing Antipsychotic or Adding a Dopamine Agonist, Rather Than Maintaining the Current Regimen, Normalize the Prolactin Levels Without Triggering Psychotic Relapse or Increasing the Risk of Life-Threatening Adverse Events? A Systematic Review |
| title_sort | in elderly patients with antipsychotic induced hyperprolactinemia could switching to a prolactin sparing antipsychotic or adding a dopamine agonist rather than maintaining the current regimen normalize the prolactin levels without triggering psychotic relapse or increasing the risk of life threatening adverse events a systematic review |
| url | https://www.cambridge.org/core/product/identifier/S2056472425102366/type/journal_article |
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