Assessing the Effect of Riluzole on Motor Unit Discharge Properties
<b>Background.</b> This study aims to determine if Riluzole usage can change the function and excitability of motor neurons. <b>Methods.</b> The clinical data and indices of motor neuron excitability were assessed using high-density surface EMG parameters from 80 ALS particip...
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MDPI AG
2024-10-01
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| author | Ehsan Shandiz Gabriel Lima Fernandes Joao Saldanha Henkin Pamela Ann McCombe Gabriel Siqueira Trajano Robert David Henderson |
| author_facet | Ehsan Shandiz Gabriel Lima Fernandes Joao Saldanha Henkin Pamela Ann McCombe Gabriel Siqueira Trajano Robert David Henderson |
| author_sort | Ehsan Shandiz |
| collection | DOAJ |
| description | <b>Background.</b> This study aims to determine if Riluzole usage can change the function and excitability of motor neurons. <b>Methods.</b> The clinical data and indices of motor neuron excitability were assessed using high-density surface EMG parameters from 80 ALS participants. The persistent inward current was assessed using the discharge rate from paired motor units obtained from the tibialis anterior muscle. This enabled the discharge rate at recruitment, peak discharge rates and the hysteresis of the recruitment–derecruitment frequencies (also known as delta F) to be calculated. Limbs were classified according to their strength. <b>Results.</b> No differences in these motor neuron discharge properties were found according to whether Riluzole was used. <b>Conclusions.</b> The possible interpretations of this finding are discussed. |
| format | Article |
| id | doaj-art-e8ac09f3650a44e1ab3e6feddb406443 |
| institution | OA Journals |
| issn | 2076-3425 |
| language | English |
| publishDate | 2024-10-01 |
| publisher | MDPI AG |
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| series | Brain Sciences |
| spelling | doaj-art-e8ac09f3650a44e1ab3e6feddb4064432025-08-20T02:08:13ZengMDPI AGBrain Sciences2076-34252024-10-011411105310.3390/brainsci14111053Assessing the Effect of Riluzole on Motor Unit Discharge PropertiesEhsan Shandiz0Gabriel Lima Fernandes1Joao Saldanha Henkin2Pamela Ann McCombe3Gabriel Siqueira Trajano4Robert David Henderson5Department of Neurology, Toowoomba Base Hospital, Toowoomba, QLD 4350, AustraliaSchool of Exercise & Nutrition Sciences, Queensland University of Technology, Brisbane, QLD 4000, AustraliaSchool of Exercise & Nutrition Sciences, Queensland University of Technology, Brisbane, QLD 4000, AustraliaCentre for Clinical Research, University of Queensland, Brisbane, QLD 4006, AustraliaSchool of Exercise & Nutrition Sciences, Queensland University of Technology, Brisbane, QLD 4000, AustraliaCentre for Clinical Research, University of Queensland, Brisbane, QLD 4006, Australia<b>Background.</b> This study aims to determine if Riluzole usage can change the function and excitability of motor neurons. <b>Methods.</b> The clinical data and indices of motor neuron excitability were assessed using high-density surface EMG parameters from 80 ALS participants. The persistent inward current was assessed using the discharge rate from paired motor units obtained from the tibialis anterior muscle. This enabled the discharge rate at recruitment, peak discharge rates and the hysteresis of the recruitment–derecruitment frequencies (also known as delta F) to be calculated. Limbs were classified according to their strength. <b>Results.</b> No differences in these motor neuron discharge properties were found according to whether Riluzole was used. <b>Conclusions.</b> The possible interpretations of this finding are discussed.https://www.mdpi.com/2076-3425/14/11/1053ALSMNDmulti-channel surface EMGHDsEMGriluzoleelectromyography |
| spellingShingle | Ehsan Shandiz Gabriel Lima Fernandes Joao Saldanha Henkin Pamela Ann McCombe Gabriel Siqueira Trajano Robert David Henderson Assessing the Effect of Riluzole on Motor Unit Discharge Properties Brain Sciences ALS MND multi-channel surface EMG HDsEMG riluzole electromyography |
| title | Assessing the Effect of Riluzole on Motor Unit Discharge Properties |
| title_full | Assessing the Effect of Riluzole on Motor Unit Discharge Properties |
| title_fullStr | Assessing the Effect of Riluzole on Motor Unit Discharge Properties |
| title_full_unstemmed | Assessing the Effect of Riluzole on Motor Unit Discharge Properties |
| title_short | Assessing the Effect of Riluzole on Motor Unit Discharge Properties |
| title_sort | assessing the effect of riluzole on motor unit discharge properties |
| topic | ALS MND multi-channel surface EMG HDsEMG riluzole electromyography |
| url | https://www.mdpi.com/2076-3425/14/11/1053 |
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