Retracted: Effects of silver nanoparticles coated with anti‐HER2 on irradiation efficiency of SKBR3 breast cancer cells
Breast cancer is the second cause of death in the world. Ionising radiation is a potent mutagen that can cause DNA damage, chromosomes breakage, and cell death. In the present study, radiotherapy and nanoparticle‐antibodies (ABs) have been combined to enhance the efficacy of cancer cell treatment. S...
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| Format: | Article |
| Language: | English |
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Wiley
2019-10-01
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| Series: | IET Nanobiotechnology |
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| Online Access: | https://doi.org/10.1049/iet-nbt.2018.5258 |
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| author | Shahin Aghamiri Ali Jafarpour Mohsen Shoja |
| author_facet | Shahin Aghamiri Ali Jafarpour Mohsen Shoja |
| author_sort | Shahin Aghamiri |
| collection | DOAJ |
| description | Breast cancer is the second cause of death in the world. Ionising radiation is a potent mutagen that can cause DNA damage, chromosomes breakage, and cell death. In the present study, radiotherapy and nanoparticle‐antibodies (ABs) have been combined to enhance the efficacy of cancer cell treatment. Silver nanoparticles (SNP) were synthesised, coated with anti‐HER2, and then characterised with different techniques such as X‐ray diffraction, dynamic light scattering, transmission electron microscopy, Fourier transform infrared, and UV–Vis spectroscopy. SKBR3 cells were irradiated with cobalt‐60 in the presence of nanoparticle‐AB as the drug. Cell viability was measured using the diphenyltetrazolium bromide assay, and the cellular status was assessed by Raman spectroscopy. Irradiation considerably decreased cell viability proportionate to the dose increase and post‐irradiation time. The surface‐enhanced Raman spectroscopy increased the signal in the presence of SNP. Increasing the dose to 2 Gy increased the irradiation resistance, and higher dose increases (4 and 6 Gy) enhanced the irradiation sensitivity. Moreover, the cellular changes induced by irradiation in the presence of the drug were stable after 48 h. The authors results introduced the combination of the drug with radiation as an effective treatment for cancer and Raman spectroscopy as a suitable tool to diagnose effective irradiation doses. |
| format | Article |
| id | doaj-art-e8aaa0186cd94bba955587e4a57d60c5 |
| institution | OA Journals |
| issn | 1751-8741 1751-875X |
| language | English |
| publishDate | 2019-10-01 |
| publisher | Wiley |
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| series | IET Nanobiotechnology |
| spelling | doaj-art-e8aaa0186cd94bba955587e4a57d60c52025-08-20T02:22:01ZengWileyIET Nanobiotechnology1751-87411751-875X2019-10-0113880881510.1049/iet-nbt.2018.5258Retracted: Effects of silver nanoparticles coated with anti‐HER2 on irradiation efficiency of SKBR3 breast cancer cellsShahin Aghamiri0Ali Jafarpour1Mohsen Shoja2Student Research CommitteeDepartment of Medical BiotechnologySchool of Advanced Technologies in Medicine, Shahid Beheshti University of Medical SciencesTehranIranVirology DivisionDepartment of PathobiologySchool of Public Health, Tehran University of Medical SciencesTehranIranFaculty of ParamedicineSemnan University of Medical SciencesSemnanIranBreast cancer is the second cause of death in the world. Ionising radiation is a potent mutagen that can cause DNA damage, chromosomes breakage, and cell death. In the present study, radiotherapy and nanoparticle‐antibodies (ABs) have been combined to enhance the efficacy of cancer cell treatment. Silver nanoparticles (SNP) were synthesised, coated with anti‐HER2, and then characterised with different techniques such as X‐ray diffraction, dynamic light scattering, transmission electron microscopy, Fourier transform infrared, and UV–Vis spectroscopy. SKBR3 cells were irradiated with cobalt‐60 in the presence of nanoparticle‐AB as the drug. Cell viability was measured using the diphenyltetrazolium bromide assay, and the cellular status was assessed by Raman spectroscopy. Irradiation considerably decreased cell viability proportionate to the dose increase and post‐irradiation time. The surface‐enhanced Raman spectroscopy increased the signal in the presence of SNP. Increasing the dose to 2 Gy increased the irradiation resistance, and higher dose increases (4 and 6 Gy) enhanced the irradiation sensitivity. Moreover, the cellular changes induced by irradiation in the presence of the drug were stable after 48 h. The authors results introduced the combination of the drug with radiation as an effective treatment for cancer and Raman spectroscopy as a suitable tool to diagnose effective irradiation doses.https://doi.org/10.1049/iet-nbt.2018.5258higher dose increasesirradiation sensitivitydrugeffective treatmenteffective irradiation dosessilver nanoparticles |
| spellingShingle | Shahin Aghamiri Ali Jafarpour Mohsen Shoja Retracted: Effects of silver nanoparticles coated with anti‐HER2 on irradiation efficiency of SKBR3 breast cancer cells IET Nanobiotechnology higher dose increases irradiation sensitivity drug effective treatment effective irradiation doses silver nanoparticles |
| title | Retracted: Effects of silver nanoparticles coated with anti‐HER2 on irradiation efficiency of SKBR3 breast cancer cells |
| title_full | Retracted: Effects of silver nanoparticles coated with anti‐HER2 on irradiation efficiency of SKBR3 breast cancer cells |
| title_fullStr | Retracted: Effects of silver nanoparticles coated with anti‐HER2 on irradiation efficiency of SKBR3 breast cancer cells |
| title_full_unstemmed | Retracted: Effects of silver nanoparticles coated with anti‐HER2 on irradiation efficiency of SKBR3 breast cancer cells |
| title_short | Retracted: Effects of silver nanoparticles coated with anti‐HER2 on irradiation efficiency of SKBR3 breast cancer cells |
| title_sort | retracted effects of silver nanoparticles coated with anti her2 on irradiation efficiency of skbr3 breast cancer cells |
| topic | higher dose increases irradiation sensitivity drug effective treatment effective irradiation doses silver nanoparticles |
| url | https://doi.org/10.1049/iet-nbt.2018.5258 |
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