The Emerging Roles of Vacuolar-Type ATPase-Dependent Lysosomal Acidification in Cardiovascular Disease
The vacuolar-type ATPase (V-ATPase) is a multi-subunit enzyme complex that maintains lysosomal acidification, a critical process for cellular homeostasis. By controlling the pH within lysosomes, V-ATPase contributes to overall cellular homeostasis, helping to maintain a balance between the degradati...
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MDPI AG
2025-04-01
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| Series: | Biomolecules |
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| Online Access: | https://www.mdpi.com/2218-273X/15/4/525 |
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| author | Yan-Yan Chen Cai-Xia Liu Hai-Xin Liu Shi-Yuan Wen |
| author_facet | Yan-Yan Chen Cai-Xia Liu Hai-Xin Liu Shi-Yuan Wen |
| author_sort | Yan-Yan Chen |
| collection | DOAJ |
| description | The vacuolar-type ATPase (V-ATPase) is a multi-subunit enzyme complex that maintains lysosomal acidification, a critical process for cellular homeostasis. By controlling the pH within lysosomes, V-ATPase contributes to overall cellular homeostasis, helping to maintain a balance between the degradation and synthesis of cellular components. Dysfunction of V-ATPase impairs lysosomal acidification, leading to the accumulation of undigested materials and contributing to various diseases, including cardiovascular diseases (CVDs) like atherosclerosis and myocardial disease. Furthermore, V-ATPase’s role in lysosomal function suggests potential therapeutic strategies targeting this enzyme complex to mitigate cardiovascular disease progression. Understanding the mechanisms by which V-ATPase influences cardiovascular pathology is essential for developing novel treatments aimed at improving outcomes in patients with heart and vascular diseases. |
| format | Article |
| id | doaj-art-e8aa0a70e16741ca8e6d90fcc45c61a0 |
| institution | DOAJ |
| issn | 2218-273X |
| language | English |
| publishDate | 2025-04-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Biomolecules |
| spelling | doaj-art-e8aa0a70e16741ca8e6d90fcc45c61a02025-08-20T03:14:21ZengMDPI AGBiomolecules2218-273X2025-04-0115452510.3390/biom15040525The Emerging Roles of Vacuolar-Type ATPase-Dependent Lysosomal Acidification in Cardiovascular DiseaseYan-Yan Chen0Cai-Xia Liu1Hai-Xin Liu2Shi-Yuan Wen3School of Medicine, Jiangsu University, Zhenjiang 212013, ChinaCollege of Traditional Chinese Medicine and Food Engineering, Shanxi University of Chinese Medicine, Taiyuan 030024, ChinaCollege of Traditional Chinese Medicine and Food Engineering, Shanxi University of Chinese Medicine, Taiyuan 030024, ChinaCollege of Basic Medical Sciences, Shanxi Medical University, Taiyuan 030001, ChinaThe vacuolar-type ATPase (V-ATPase) is a multi-subunit enzyme complex that maintains lysosomal acidification, a critical process for cellular homeostasis. By controlling the pH within lysosomes, V-ATPase contributes to overall cellular homeostasis, helping to maintain a balance between the degradation and synthesis of cellular components. Dysfunction of V-ATPase impairs lysosomal acidification, leading to the accumulation of undigested materials and contributing to various diseases, including cardiovascular diseases (CVDs) like atherosclerosis and myocardial disease. Furthermore, V-ATPase’s role in lysosomal function suggests potential therapeutic strategies targeting this enzyme complex to mitigate cardiovascular disease progression. Understanding the mechanisms by which V-ATPase influences cardiovascular pathology is essential for developing novel treatments aimed at improving outcomes in patients with heart and vascular diseases.https://www.mdpi.com/2218-273X/15/4/525vacuolar-type ATPaselysosomal acidificationcardiovascular disease |
| spellingShingle | Yan-Yan Chen Cai-Xia Liu Hai-Xin Liu Shi-Yuan Wen The Emerging Roles of Vacuolar-Type ATPase-Dependent Lysosomal Acidification in Cardiovascular Disease Biomolecules vacuolar-type ATPase lysosomal acidification cardiovascular disease |
| title | The Emerging Roles of Vacuolar-Type ATPase-Dependent Lysosomal Acidification in Cardiovascular Disease |
| title_full | The Emerging Roles of Vacuolar-Type ATPase-Dependent Lysosomal Acidification in Cardiovascular Disease |
| title_fullStr | The Emerging Roles of Vacuolar-Type ATPase-Dependent Lysosomal Acidification in Cardiovascular Disease |
| title_full_unstemmed | The Emerging Roles of Vacuolar-Type ATPase-Dependent Lysosomal Acidification in Cardiovascular Disease |
| title_short | The Emerging Roles of Vacuolar-Type ATPase-Dependent Lysosomal Acidification in Cardiovascular Disease |
| title_sort | emerging roles of vacuolar type atpase dependent lysosomal acidification in cardiovascular disease |
| topic | vacuolar-type ATPase lysosomal acidification cardiovascular disease |
| url | https://www.mdpi.com/2218-273X/15/4/525 |
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