Cardiomyopathy: pathogenesis and therapeutic interventions
Abstract Cardiomyopathy is a group of disease characterized by structural and functional damage to the myocardium. The etiologies of cardiomyopathies are diverse, spanning from genetic mutations impacting fundamental myocardial functions to systemic disorders that result in widespread cardiac damage...
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| Format: | Article |
| Language: | English |
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Wiley
2024-11-01
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| Series: | MedComm |
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| Online Access: | https://doi.org/10.1002/mco2.772 |
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| author | Shitong Huang Jiaxin Li Qiuying Li Qiuyu Wang Xianwu Zhou Jimei Chen Xuanhui Chen Abdelouahab Bellou Jian Zhuang Liming Lei |
| author_facet | Shitong Huang Jiaxin Li Qiuying Li Qiuyu Wang Xianwu Zhou Jimei Chen Xuanhui Chen Abdelouahab Bellou Jian Zhuang Liming Lei |
| author_sort | Shitong Huang |
| collection | DOAJ |
| description | Abstract Cardiomyopathy is a group of disease characterized by structural and functional damage to the myocardium. The etiologies of cardiomyopathies are diverse, spanning from genetic mutations impacting fundamental myocardial functions to systemic disorders that result in widespread cardiac damage. Many specific gene mutations cause primary cardiomyopathy. Environmental factors and metabolic disorders may also lead to the occurrence of cardiomyopathy. This review provides an in‐depth analysis of the current understanding of the pathogenesis of various cardiomyopathies, highlighting the molecular and cellular mechanisms that contribute to their development and progression. The current therapeutic interventions for cardiomyopathies range from pharmacological interventions to mechanical support and heart transplantation. Gene therapy and cell therapy, propelled by ongoing advancements in overarching strategies and methodologies, has also emerged as a pivotal clinical intervention for a variety of diseases. The increasing number of causal gene of cardiomyopathies have been identified in recent studies. Therefore, gene therapy targeting causal genes holds promise in offering therapeutic advantages to individuals diagnosed with cardiomyopathies. Acting as a more precise approach to gene therapy, they are gradually emerging as a substitute for traditional gene therapy. This article reviews pathogenesis and therapeutic interventions for different cardiomyopathies. |
| format | Article |
| id | doaj-art-e8a753c742aa4ffd9d2c7e54a19c7369 |
| institution | Kabale University |
| issn | 2688-2663 |
| language | English |
| publishDate | 2024-11-01 |
| publisher | Wiley |
| record_format | Article |
| series | MedComm |
| spelling | doaj-art-e8a753c742aa4ffd9d2c7e54a19c73692024-11-14T16:14:36ZengWileyMedComm2688-26632024-11-01511n/an/a10.1002/mco2.772Cardiomyopathy: pathogenesis and therapeutic interventionsShitong Huang0Jiaxin Li1Qiuying Li2Qiuyu Wang3Xianwu Zhou4Jimei Chen5Xuanhui Chen6Abdelouahab Bellou7Jian Zhuang8Liming Lei9Department of Cardiac Surgical Intensive Care Unit Guangdong Cardiovascular Institute Guangdong Provincial People's Hospital (Guangdong Academy of Medical Sciences) Southern Medical University Guangzhou ChinaDepartment of Cardiac Surgical Intensive Care Unit Guangdong Cardiovascular Institute Guangdong Provincial People's Hospital (Guangdong Academy of Medical Sciences) Southern Medical University Guangzhou ChinaDepartment of Cardiac Surgical Intensive Care Unit Guangdong Cardiovascular Institute Guangdong Provincial People's Hospital (Guangdong Academy of Medical Sciences) Southern Medical University Guangzhou ChinaDepartment of Cardiac Surgical Intensive Care Unit Guangdong Cardiovascular Institute Guangdong Provincial People's Hospital (Guangdong Academy of Medical Sciences) Southern Medical University Guangzhou ChinaDepartment of Cardiovascular Surgery Zhongnan Hospital of Wuhan University Wuhan ChinaDepartment of Cardiovascular Surgery Guangdong Cardiovascular Institute Guangdong Provincial People's Hospital (Guangdong Academy of Medical Sciences) Southern Medical University Guangzhou ChinaDepartment of Medical Big Data Center Guangdong Provincial People's Hospital (Guangdong Academy of Medical Sciences) Southern Medical University Guangzhou ChinaDepartment of Emergency Medicine, Institute of Sciences in Emergency Medicine Guangdong Provincial People's Hospital (Guangdong Academy of Medical Sciences) Southern Medical University Guangzhou ChinaDepartment of Cardiovascular Surgery Guangdong Cardiovascular Institute Guangdong Provincial People's Hospital (Guangdong Academy of Medical Sciences) Southern Medical University Guangzhou ChinaDepartment of Cardiac Surgical Intensive Care Unit Guangdong Cardiovascular Institute Guangdong Provincial People's Hospital (Guangdong Academy of Medical Sciences) Southern Medical University Guangzhou ChinaAbstract Cardiomyopathy is a group of disease characterized by structural and functional damage to the myocardium. The etiologies of cardiomyopathies are diverse, spanning from genetic mutations impacting fundamental myocardial functions to systemic disorders that result in widespread cardiac damage. Many specific gene mutations cause primary cardiomyopathy. Environmental factors and metabolic disorders may also lead to the occurrence of cardiomyopathy. This review provides an in‐depth analysis of the current understanding of the pathogenesis of various cardiomyopathies, highlighting the molecular and cellular mechanisms that contribute to their development and progression. The current therapeutic interventions for cardiomyopathies range from pharmacological interventions to mechanical support and heart transplantation. Gene therapy and cell therapy, propelled by ongoing advancements in overarching strategies and methodologies, has also emerged as a pivotal clinical intervention for a variety of diseases. The increasing number of causal gene of cardiomyopathies have been identified in recent studies. Therefore, gene therapy targeting causal genes holds promise in offering therapeutic advantages to individuals diagnosed with cardiomyopathies. Acting as a more precise approach to gene therapy, they are gradually emerging as a substitute for traditional gene therapy. This article reviews pathogenesis and therapeutic interventions for different cardiomyopathies.https://doi.org/10.1002/mco2.772cardiomyopathydisease‐causing genegene therapypathogenesispersonalized medicinetherapeutic interventions |
| spellingShingle | Shitong Huang Jiaxin Li Qiuying Li Qiuyu Wang Xianwu Zhou Jimei Chen Xuanhui Chen Abdelouahab Bellou Jian Zhuang Liming Lei Cardiomyopathy: pathogenesis and therapeutic interventions MedComm cardiomyopathy disease‐causing gene gene therapy pathogenesis personalized medicine therapeutic interventions |
| title | Cardiomyopathy: pathogenesis and therapeutic interventions |
| title_full | Cardiomyopathy: pathogenesis and therapeutic interventions |
| title_fullStr | Cardiomyopathy: pathogenesis and therapeutic interventions |
| title_full_unstemmed | Cardiomyopathy: pathogenesis and therapeutic interventions |
| title_short | Cardiomyopathy: pathogenesis and therapeutic interventions |
| title_sort | cardiomyopathy pathogenesis and therapeutic interventions |
| topic | cardiomyopathy disease‐causing gene gene therapy pathogenesis personalized medicine therapeutic interventions |
| url | https://doi.org/10.1002/mco2.772 |
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