Retinoblastoma: Evolving Concepts and Future Challenges
Retinoblastoma is the most common ocular malignancy in children. It results from mutations in the RB1 gene or from MYCN oncogene amplification. We distinguish between the more common unilateral form and the rarer bilateral form. It is important to note that bilateral retinoblastoma is always heredi...
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| Format: | Article |
| Language: | English |
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Nicolaus Copernicus University in Toruń
2025-08-01
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| Series: | Quality in Sport |
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| Online Access: | https://apcz.umk.pl/QS/article/view/62962 |
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| author | Mateusz Wiekiera Adrianna Jasiuk Natalia Madeja Sylwia Koziej Martyna Niemczuk Emilia Kowalczyk |
| author_facet | Mateusz Wiekiera Adrianna Jasiuk Natalia Madeja Sylwia Koziej Martyna Niemczuk Emilia Kowalczyk |
| author_sort | Mateusz Wiekiera |
| collection | DOAJ |
| description |
Retinoblastoma is the most common ocular malignancy in children. It results from mutations in the RB1 gene or from MYCN oncogene amplification. We distinguish between the more common unilateral form and the rarer bilateral form. It is important to note that bilateral retinoblastoma is always hereditary. The most common and characteristic symptom is the white pupillary reflex. In addition, the child may develop strabismus or heterochromia. Treatment methods vary, ranging from those aimed at salvaging the eye to those involving total enucleation. Prognosis depends on the location and stage of the tumor. This review aims to explore the literature on new therapeutic methods and recent discoveries in the field of retinoblastoma.
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| format | Article |
| id | doaj-art-e89f1df2ce194178a60f840f6efea038 |
| institution | DOAJ |
| issn | 2450-3118 |
| language | English |
| publishDate | 2025-08-01 |
| publisher | Nicolaus Copernicus University in Toruń |
| record_format | Article |
| series | Quality in Sport |
| spelling | doaj-art-e89f1df2ce194178a60f840f6efea0382025-08-20T03:06:44ZengNicolaus Copernicus University in ToruńQuality in Sport2450-31182025-08-014410.12775/QS.2025.44.62962Retinoblastoma: Evolving Concepts and Future ChallengesMateusz Wiekiera0https://orcid.org/0009-0003-9236-2913Adrianna Jasiuk1https://orcid.org/0009-0001-4829-3768Natalia Madeja2https://orcid.org/0009-0004-0921-8003Sylwia Koziej3https://orcid.org/0009-0002-9607-6693Martyna Niemczuk4https://orcid.org/0009-0006-5877-6356Emilia Kowalczyk5https://orcid.org/0000-0001-7687-8870Medical University of ŁódźMedical University of LodzNational Research InstituteWyszynski Provincial Specialist Hospital SPZOZ ,LublinUniversity Clinical Hospital, BiałystokProvincial Hospital in Kielce Retinoblastoma is the most common ocular malignancy in children. It results from mutations in the RB1 gene or from MYCN oncogene amplification. We distinguish between the more common unilateral form and the rarer bilateral form. It is important to note that bilateral retinoblastoma is always hereditary. The most common and characteristic symptom is the white pupillary reflex. In addition, the child may develop strabismus or heterochromia. Treatment methods vary, ranging from those aimed at salvaging the eye to those involving total enucleation. Prognosis depends on the location and stage of the tumor. This review aims to explore the literature on new therapeutic methods and recent discoveries in the field of retinoblastoma. https://apcz.umk.pl/QS/article/view/62962RetinoblastomaHeterochromia |
| spellingShingle | Mateusz Wiekiera Adrianna Jasiuk Natalia Madeja Sylwia Koziej Martyna Niemczuk Emilia Kowalczyk Retinoblastoma: Evolving Concepts and Future Challenges Quality in Sport Retinoblastoma Heterochromia |
| title | Retinoblastoma: Evolving Concepts and Future Challenges |
| title_full | Retinoblastoma: Evolving Concepts and Future Challenges |
| title_fullStr | Retinoblastoma: Evolving Concepts and Future Challenges |
| title_full_unstemmed | Retinoblastoma: Evolving Concepts and Future Challenges |
| title_short | Retinoblastoma: Evolving Concepts and Future Challenges |
| title_sort | retinoblastoma evolving concepts and future challenges |
| topic | Retinoblastoma Heterochromia |
| url | https://apcz.umk.pl/QS/article/view/62962 |
| work_keys_str_mv | AT mateuszwiekiera retinoblastomaevolvingconceptsandfuturechallenges AT adriannajasiuk retinoblastomaevolvingconceptsandfuturechallenges AT nataliamadeja retinoblastomaevolvingconceptsandfuturechallenges AT sylwiakoziej retinoblastomaevolvingconceptsandfuturechallenges AT martynaniemczuk retinoblastomaevolvingconceptsandfuturechallenges AT emiliakowalczyk retinoblastomaevolvingconceptsandfuturechallenges |