Infusion therapy for chronic liver diseases
Aim of review. To present modern options of comprehensive infusion therapy at various liver diseases, indications and contraindications for application of basic blood substitute groups, and pathogenically justified approaches for their use. Summary. Chronic and acute liver diseases are associated to...
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| Format: | Article |
| Language: | Russian |
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Gastro LLC
2018-08-01
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| Series: | Российский журнал гастроэнтерологии, гепатологии, колопроктологии |
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| Online Access: | https://www.gastro-j.ru/jour/article/view/243 |
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| author | I. A. Kurkina M. V. Mayevskaya I. N. Tikhonov V. N. Zozulya V. I. Leschenko |
| author_facet | I. A. Kurkina M. V. Mayevskaya I. N. Tikhonov V. N. Zozulya V. I. Leschenko |
| author_sort | I. A. Kurkina |
| collection | DOAJ |
| description | Aim of review. To present modern options of comprehensive infusion therapy at various liver diseases, indications and contraindications for application of basic blood substitute groups, and pathogenically justified approaches for their use. Summary. Chronic and acute liver diseases are associated to end the genius intoxication, electrolyte disorders, shift of acid-base state, tissue and cellular hypoxia. Infusion therapy with application of modern plasma substitute solutions provide increase in treatment efficacy for this group of patients. Application of basic group infusion solutions along with complex anti-hypoxia agents helps to correct water and electrolyte imbalance as well as disorders of acid-base state, carry out body detoxication, normalize blood pressure, treat edema and ascites syndrome, protein-energy malnutrition, prevent renal value and other complications in liver cirrhosis patients. Comprehensive treatment of liver diseases includes application of modern infusion agents (anti-hypoxia/anti-oxidation) containing pharmacologically active metabolic substances that include succinate-containing drugs developed on the basis of succinic acid and its salts. Succinic acid is presumed to act as the paracrine agent produced by damage hepatocytes (e.g. at ischemia), affecting pericytes (Ito's cell) in the liver through SUCNR1receptors. It results activation of pericytes providing synthesis of extracellular matrix components that are involved in metabolism and regeneration of liver parenchyma cells. Conclusion. Addition of succinic acid-based medications to infusion therapy program for chronic liver diseases provides alleviation of basic clinical syndromes (intoxication, asthenic and autonomous nervous disorders, dyspeptic, cholestatic), and at patients with hepatocellular failure improvement of protein-synthetic liver function. |
| format | Article |
| id | doaj-art-e898c4466b08491aaa703044cd181c90 |
| institution | Kabale University |
| issn | 1382-4376 2658-6673 |
| language | Russian |
| publishDate | 2018-08-01 |
| publisher | Gastro LLC |
| record_format | Article |
| series | Российский журнал гастроэнтерологии, гепатологии, колопроктологии |
| spelling | doaj-art-e898c4466b08491aaa703044cd181c902025-02-10T16:14:29ZrusGastro LLCРоссийский журнал гастроэнтерологии, гепатологии, колопроктологии1382-43762658-66732018-08-01283818710.22416/1382-4376-2018-28-3-81-87243Infusion therapy for chronic liver diseasesI. A. Kurkina0M. V. Mayevskaya1I. N. Tikhonov2V. N. Zozulya3V. I. Leschenko4Sechenov First Moscow State Medical UniversitySechenov First Moscow State Medical UniversitySechenov First Moscow State Medical UniversitySechenov First Moscow State Medical UniversitySechenov First Moscow State Medical UniversityAim of review. To present modern options of comprehensive infusion therapy at various liver diseases, indications and contraindications for application of basic blood substitute groups, and pathogenically justified approaches for their use. Summary. Chronic and acute liver diseases are associated to end the genius intoxication, electrolyte disorders, shift of acid-base state, tissue and cellular hypoxia. Infusion therapy with application of modern plasma substitute solutions provide increase in treatment efficacy for this group of patients. Application of basic group infusion solutions along with complex anti-hypoxia agents helps to correct water and electrolyte imbalance as well as disorders of acid-base state, carry out body detoxication, normalize blood pressure, treat edema and ascites syndrome, protein-energy malnutrition, prevent renal value and other complications in liver cirrhosis patients. Comprehensive treatment of liver diseases includes application of modern infusion agents (anti-hypoxia/anti-oxidation) containing pharmacologically active metabolic substances that include succinate-containing drugs developed on the basis of succinic acid and its salts. Succinic acid is presumed to act as the paracrine agent produced by damage hepatocytes (e.g. at ischemia), affecting pericytes (Ito's cell) in the liver through SUCNR1receptors. It results activation of pericytes providing synthesis of extracellular matrix components that are involved in metabolism and regeneration of liver parenchyma cells. Conclusion. Addition of succinic acid-based medications to infusion therapy program for chronic liver diseases provides alleviation of basic clinical syndromes (intoxication, asthenic and autonomous nervous disorders, dyspeptic, cholestatic), and at patients with hepatocellular failure improvement of protein-synthetic liver function.https://www.gastro-j.ru/jour/article/view/243инфузионная терапиягепатитцирроз печениальбуминянтарная кислота |
| spellingShingle | I. A. Kurkina M. V. Mayevskaya I. N. Tikhonov V. N. Zozulya V. I. Leschenko Infusion therapy for chronic liver diseases Российский журнал гастроэнтерологии, гепатологии, колопроктологии инфузионная терапия гепатит цирроз печени альбумин янтарная кислота |
| title | Infusion therapy for chronic liver diseases |
| title_full | Infusion therapy for chronic liver diseases |
| title_fullStr | Infusion therapy for chronic liver diseases |
| title_full_unstemmed | Infusion therapy for chronic liver diseases |
| title_short | Infusion therapy for chronic liver diseases |
| title_sort | infusion therapy for chronic liver diseases |
| topic | инфузионная терапия гепатит цирроз печени альбумин янтарная кислота |
| url | https://www.gastro-j.ru/jour/article/view/243 |
| work_keys_str_mv | AT iakurkina infusiontherapyforchronicliverdiseases AT mvmayevskaya infusiontherapyforchronicliverdiseases AT intikhonov infusiontherapyforchronicliverdiseases AT vnzozulya infusiontherapyforchronicliverdiseases AT vileschenko infusiontherapyforchronicliverdiseases |