Two-Step Synthesis of a Dolutegravir Intermediate DTG‑6 in a Microfluidized Bed Cascade System: Route Design and Kinetic Study

Saved in:
Bibliographic Details
Main Authors: Xiao Xue, Chengmin Xie, Guozhi Qian, Minjing Shang, Min Qiu, Rongkun Jiang, Mohsin Pasha, Zihao Zhong, Zhijun Wang, Shu Liu, Hua Zhang, Yuanhai Su
Format: Article
Language:English
Published: American Chemical Society 2024-11-01
Series:Chem & Bio Engineering
Online Access:https://doi.org/10.1021/cbe.4c00139
Tags: Add Tag
No Tags, Be the first to tag this record!
_version_ 1850277685870198784
author Xiao Xue
Chengmin Xie
Guozhi Qian
Minjing Shang
Min Qiu
Rongkun Jiang
Mohsin Pasha
Zihao Zhong
Zhijun Wang
Shu Liu
Hua Zhang
Yuanhai Su
author_facet Xiao Xue
Chengmin Xie
Guozhi Qian
Minjing Shang
Min Qiu
Rongkun Jiang
Mohsin Pasha
Zihao Zhong
Zhijun Wang
Shu Liu
Hua Zhang
Yuanhai Su
author_sort Xiao Xue
collection DOAJ
format Article
id doaj-art-e898c21391f240d88b1107a01cdd9f80
institution OA Journals
issn 2836-967X
language English
publishDate 2024-11-01
publisher American Chemical Society
record_format Article
series Chem & Bio Engineering
spelling doaj-art-e898c21391f240d88b1107a01cdd9f802025-08-20T01:49:47ZengAmerican Chemical SocietyChem & Bio Engineering2836-967X2024-11-012318219110.1021/cbe.4c00139Two-Step Synthesis of a Dolutegravir Intermediate DTG‑6 in a Microfluidized Bed Cascade System: Route Design and Kinetic StudyXiao Xue0Chengmin Xie1Guozhi Qian2Minjing Shang3Min Qiu4Rongkun Jiang5Mohsin Pasha6Zihao Zhong7Zhijun Wang8Shu Liu9Hua Zhang10Yuanhai Su11School of Chemistry and Chemical Engineering, Key Laboratory of Thin Film and Microfabrication (Ministry of Education), Shanghai Jiao Tong University, Shanghai, People’s Republic of ChinaSchool of Chemistry and Chemical Engineering, Key Laboratory of Thin Film and Microfabrication (Ministry of Education), Shanghai Jiao Tong University, Shanghai, People’s Republic of ChinaSchool of Chemistry and Chemical Engineering, Key Laboratory of Thin Film and Microfabrication (Ministry of Education), Shanghai Jiao Tong University, Shanghai, People’s Republic of ChinaSchool of Chemistry and Chemical Engineering, Key Laboratory of Thin Film and Microfabrication (Ministry of Education), Shanghai Jiao Tong University, Shanghai, People’s Republic of ChinaSchool of Chemistry and Chemical Engineering, Key Laboratory of Thin Film and Microfabrication (Ministry of Education), Shanghai Jiao Tong University, Shanghai, People’s Republic of ChinaState Key Laboratory of Bioreactor Engineering, Shanghai Key Laboratory of Chemical Biology, School of Pharmacy, East China University of Science and Technology, Shanghai, People’s Republic of ChinaSchool of Chemistry and Chemical Engineering, Key Laboratory of Thin Film and Microfabrication (Ministry of Education), Shanghai Jiao Tong University, Shanghai, People’s Republic of ChinaSchool of Chemistry and Chemical Engineering, Key Laboratory of Thin Film and Microfabrication (Ministry of Education), Shanghai Jiao Tong University, Shanghai, People’s Republic of ChinaShanghai Desano Pharmaceuticals Co., Ltd., Shanghai, People’s Republic of ChinaShanghai Desano Pharmaceuticals Co., Ltd., Shanghai, People’s Republic of ChinaShanghai Desano Pharmaceuticals Co., Ltd., Shanghai, People’s Republic of ChinaSchool of Chemistry and Chemical Engineering, Key Laboratory of Thin Film and Microfabrication (Ministry of Education), Shanghai Jiao Tong University, Shanghai, People’s Republic of Chinahttps://doi.org/10.1021/cbe.4c00139
spellingShingle Xiao Xue
Chengmin Xie
Guozhi Qian
Minjing Shang
Min Qiu
Rongkun Jiang
Mohsin Pasha
Zihao Zhong
Zhijun Wang
Shu Liu
Hua Zhang
Yuanhai Su
Two-Step Synthesis of a Dolutegravir Intermediate DTG‑6 in a Microfluidized Bed Cascade System: Route Design and Kinetic Study
Chem & Bio Engineering
title Two-Step Synthesis of a Dolutegravir Intermediate DTG‑6 in a Microfluidized Bed Cascade System: Route Design and Kinetic Study
title_full Two-Step Synthesis of a Dolutegravir Intermediate DTG‑6 in a Microfluidized Bed Cascade System: Route Design and Kinetic Study
title_fullStr Two-Step Synthesis of a Dolutegravir Intermediate DTG‑6 in a Microfluidized Bed Cascade System: Route Design and Kinetic Study
title_full_unstemmed Two-Step Synthesis of a Dolutegravir Intermediate DTG‑6 in a Microfluidized Bed Cascade System: Route Design and Kinetic Study
title_short Two-Step Synthesis of a Dolutegravir Intermediate DTG‑6 in a Microfluidized Bed Cascade System: Route Design and Kinetic Study
title_sort two step synthesis of a dolutegravir intermediate dtg 6 in a microfluidized bed cascade system route design and kinetic study
url https://doi.org/10.1021/cbe.4c00139
work_keys_str_mv AT xiaoxue twostepsynthesisofadolutegravirintermediatedtg6inamicrofluidizedbedcascadesystemroutedesignandkineticstudy
AT chengminxie twostepsynthesisofadolutegravirintermediatedtg6inamicrofluidizedbedcascadesystemroutedesignandkineticstudy
AT guozhiqian twostepsynthesisofadolutegravirintermediatedtg6inamicrofluidizedbedcascadesystemroutedesignandkineticstudy
AT minjingshang twostepsynthesisofadolutegravirintermediatedtg6inamicrofluidizedbedcascadesystemroutedesignandkineticstudy
AT minqiu twostepsynthesisofadolutegravirintermediatedtg6inamicrofluidizedbedcascadesystemroutedesignandkineticstudy
AT rongkunjiang twostepsynthesisofadolutegravirintermediatedtg6inamicrofluidizedbedcascadesystemroutedesignandkineticstudy
AT mohsinpasha twostepsynthesisofadolutegravirintermediatedtg6inamicrofluidizedbedcascadesystemroutedesignandkineticstudy
AT zihaozhong twostepsynthesisofadolutegravirintermediatedtg6inamicrofluidizedbedcascadesystemroutedesignandkineticstudy
AT zhijunwang twostepsynthesisofadolutegravirintermediatedtg6inamicrofluidizedbedcascadesystemroutedesignandkineticstudy
AT shuliu twostepsynthesisofadolutegravirintermediatedtg6inamicrofluidizedbedcascadesystemroutedesignandkineticstudy
AT huazhang twostepsynthesisofadolutegravirintermediatedtg6inamicrofluidizedbedcascadesystemroutedesignandkineticstudy
AT yuanhaisu twostepsynthesisofadolutegravirintermediatedtg6inamicrofluidizedbedcascadesystemroutedesignandkineticstudy