Role of Genetic and Epigenetic Factors and Mechanisms Involved in the Occurrence of Congenital Heart Diseases (CHD)
Introduction: Congenital heart diseases (CHD) are complex, multifactorial cardiac disorders that result from a combination of genetic, environmental, and epigenetic factors, with genetic factors being particularly prominent. This remarkable disease affects approximately 1% of newborns and can occur...
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Shahid Sadoughi University of Medical Sciences
2025-07-01
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| Series: | Majallah-i Dānishgāh-i ’Ulūm-i Pizishkī-i Shahīd Ṣadūqī Yazd |
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| Online Access: | http://jssu.ssu.ac.ir/article-1-6377-en.pdf |
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| author | Fateme Tabrizi Mehri Khatami Mohammad Mehdi Heidari |
| author_facet | Fateme Tabrizi Mehri Khatami Mohammad Mehdi Heidari |
| author_sort | Fateme Tabrizi |
| collection | DOAJ |
| description | Introduction: Congenital heart diseases (CHD) are complex, multifactorial cardiac disorders that result from a combination of genetic, environmental, and epigenetic factors, with genetic factors being particularly prominent. This remarkable disease affects approximately 1% of newborns and can occur sporadically and familially. Sporadic cases are often associated with novel mutations or newly emerging chromosomal abnormalities, while familial cases show different inheritance patterns. Advanced research in molecular genetics, especially techniques such as whole-exome sequencing and chromosomal microarray analysis, which focus on protein-coding regions of the human genome, has identified hundreds of genes associated with the development of CHD. However, despite these scientific advances, many of the molecular mechanisms underlying CHD remain unknown.
Conclusion: Due to modern surgical techniques, the survival rate of affected infants is increasing. Deeper insight into the exact causes of this disease is crucial for diagnosing and identifying high-risk patients and improving preventive and therapeutic strategies for CHD. This review article aims to review and describe the latest discoveries regarding the influence of genetic and epigenetic factors in the development of coronary heart disease (CHD). |
| format | Article |
| id | doaj-art-e896706694e84e53a196bf1c59b0bbda |
| institution | Kabale University |
| issn | 2228-5741 2228-5733 |
| language | fas |
| publishDate | 2025-07-01 |
| publisher | Shahid Sadoughi University of Medical Sciences |
| record_format | Article |
| series | Majallah-i Dānishgāh-i ’Ulūm-i Pizishkī-i Shahīd Ṣadūqī Yazd |
| spelling | doaj-art-e896706694e84e53a196bf1c59b0bbda2025-08-20T03:56:42ZfasShahid Sadoughi University of Medical SciencesMajallah-i Dānishgāh-i ’Ulūm-i Pizishkī-i Shahīd Ṣadūqī Yazd2228-57412228-57332025-07-0133488858912Role of Genetic and Epigenetic Factors and Mechanisms Involved in the Occurrence of Congenital Heart Diseases (CHD)Fateme Tabrizi0Mehri Khatami1Mohammad Mehdi Heidari2 Department of Biology, Yazd University, Yazd, Iran. Department of Biology, Yazd University, Yazd, Iran. Department of Biology, Yazd University, Yazd, Iran. Introduction: Congenital heart diseases (CHD) are complex, multifactorial cardiac disorders that result from a combination of genetic, environmental, and epigenetic factors, with genetic factors being particularly prominent. This remarkable disease affects approximately 1% of newborns and can occur sporadically and familially. Sporadic cases are often associated with novel mutations or newly emerging chromosomal abnormalities, while familial cases show different inheritance patterns. Advanced research in molecular genetics, especially techniques such as whole-exome sequencing and chromosomal microarray analysis, which focus on protein-coding regions of the human genome, has identified hundreds of genes associated with the development of CHD. However, despite these scientific advances, many of the molecular mechanisms underlying CHD remain unknown. Conclusion: Due to modern surgical techniques, the survival rate of affected infants is increasing. Deeper insight into the exact causes of this disease is crucial for diagnosing and identifying high-risk patients and improving preventive and therapeutic strategies for CHD. This review article aims to review and describe the latest discoveries regarding the influence of genetic and epigenetic factors in the development of coronary heart disease (CHD).http://jssu.ssu.ac.ir/article-1-6377-en.pdfcongenital heart diseaseschd geneticsepigenetic factorsgene mutationsheart development. |
| spellingShingle | Fateme Tabrizi Mehri Khatami Mohammad Mehdi Heidari Role of Genetic and Epigenetic Factors and Mechanisms Involved in the Occurrence of Congenital Heart Diseases (CHD) Majallah-i Dānishgāh-i ’Ulūm-i Pizishkī-i Shahīd Ṣadūqī Yazd congenital heart diseases chd genetics epigenetic factors gene mutations heart development. |
| title | Role of Genetic and Epigenetic Factors and Mechanisms Involved in the Occurrence of Congenital Heart Diseases (CHD) |
| title_full | Role of Genetic and Epigenetic Factors and Mechanisms Involved in the Occurrence of Congenital Heart Diseases (CHD) |
| title_fullStr | Role of Genetic and Epigenetic Factors and Mechanisms Involved in the Occurrence of Congenital Heart Diseases (CHD) |
| title_full_unstemmed | Role of Genetic and Epigenetic Factors and Mechanisms Involved in the Occurrence of Congenital Heart Diseases (CHD) |
| title_short | Role of Genetic and Epigenetic Factors and Mechanisms Involved in the Occurrence of Congenital Heart Diseases (CHD) |
| title_sort | role of genetic and epigenetic factors and mechanisms involved in the occurrence of congenital heart diseases chd |
| topic | congenital heart diseases chd genetics epigenetic factors gene mutations heart development. |
| url | http://jssu.ssu.ac.ir/article-1-6377-en.pdf |
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