Melatonin effect on Appendectomy Postoperative Pain: A Randomized Clinical Trial
Introduction: Melatonin is synthesized from the tryptophan amino acid in the pineal gland. Its role in Sleep was defined previously. Several studies have shown the effect of melatonin on postoperative pain and sedation. The aim of this study was to evaluate the effect of melatonin on postoperative p...
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Kerman University of Medical Sciences
2024-05-01
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| Series: | Journal of Kerman University of Medical Sciences |
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| Online Access: | https://jkmu.kmu.ac.ir/article_92377_750303d576a3ad47ad67fbc28629d1e9.pdf |
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| author | Alireza abdollahzadeh Baghaei Hashem Jarineshin Abbas Moallemy fereydoon Fekrat Mahla khoramvar |
| author_facet | Alireza abdollahzadeh Baghaei Hashem Jarineshin Abbas Moallemy fereydoon Fekrat Mahla khoramvar |
| author_sort | Alireza abdollahzadeh Baghaei |
| collection | DOAJ |
| description | Introduction: Melatonin is synthesized from the tryptophan amino acid in the pineal gland. Its role in Sleep was defined previously. Several studies have shown the effect of melatonin on postoperative pain and sedation. The aim of this study was to evaluate the effect of melatonin on postoperative pain in patients undergoing an appendectomy.Methods: In a double-blind clinical trial, 64 patients aged 18-80 years with an ASA Ⅰ-Ⅱ anesthesia class who had been candidates for appendectomy with general anesthesia were enrolled. Patients were randomly divided into two groups’ melatonin and placebo (each group was 32). The first group received 6 mg of oral melatonin one hour before while the second group received a placebo. Before surgery and during the hours 2, 12, and 24 hours after surgery, patients' pain was measured based on the VAS. The patients' sedation was measured according to the Ramsay score and rescue analgesia was measured at the above time points. To analyze the data, SPSS software was used and the significance level was considered as P-value<0.05.Results: The results of our study showed that pain levels in the melatonin group were lower in the 2nd, 12, and 24th hours after the surgery of the appendectomy than in the placebo group. Sedation rates were not significantly different between the two groups. The analgesic consumption was lower in the Melatonin group than in the placebo group.Conclusion: Melatonin has a positive effect on the degree of pain (VAS) after an appendectomy. |
| format | Article |
| id | doaj-art-e88d0da7b9694386a08fb588ccc18dc2 |
| institution | DOAJ |
| issn | 1023-9510 2008-2843 |
| language | English |
| publishDate | 2024-05-01 |
| publisher | Kerman University of Medical Sciences |
| record_format | Article |
| series | Journal of Kerman University of Medical Sciences |
| spelling | doaj-art-e88d0da7b9694386a08fb588ccc18dc22025-08-20T03:01:41ZengKerman University of Medical SciencesJournal of Kerman University of Medical Sciences1023-95102008-28432024-05-01312939792377Melatonin effect on Appendectomy Postoperative Pain: A Randomized Clinical TrialAlireza abdollahzadeh Baghaei0Hashem Jarineshin1Abbas Moallemy2fereydoon Fekrat3Mahla khoramvar4Anesthesiology, Critical care, and Pain management Research center, Hormozgan University of Medical Sciences, Bandar Abbas, IRANAnesthesiology, Critical Care and Pain Management Research Center, Hormozgan University of Medical Sciences, Bandar Abbas, Iran.Anesthesiology, Critical Care and Pain Management Research Center, Hormozgan University of Medical Sciences, Bandar Abbas, Iran.Anesthesiology, Critical Care and Pain Management Research Center, Hormozgan University of Medical Sciences, Bandar Abbas, Iran.Anesthesiology, Critical Care and Pain Management Research Center, Hormozgan University of Medical Sciences, Bandar Abbas, Iran.Introduction: Melatonin is synthesized from the tryptophan amino acid in the pineal gland. Its role in Sleep was defined previously. Several studies have shown the effect of melatonin on postoperative pain and sedation. The aim of this study was to evaluate the effect of melatonin on postoperative pain in patients undergoing an appendectomy.Methods: In a double-blind clinical trial, 64 patients aged 18-80 years with an ASA Ⅰ-Ⅱ anesthesia class who had been candidates for appendectomy with general anesthesia were enrolled. Patients were randomly divided into two groups’ melatonin and placebo (each group was 32). The first group received 6 mg of oral melatonin one hour before while the second group received a placebo. Before surgery and during the hours 2, 12, and 24 hours after surgery, patients' pain was measured based on the VAS. The patients' sedation was measured according to the Ramsay score and rescue analgesia was measured at the above time points. To analyze the data, SPSS software was used and the significance level was considered as P-value<0.05.Results: The results of our study showed that pain levels in the melatonin group were lower in the 2nd, 12, and 24th hours after the surgery of the appendectomy than in the placebo group. Sedation rates were not significantly different between the two groups. The analgesic consumption was lower in the Melatonin group than in the placebo group.Conclusion: Melatonin has a positive effect on the degree of pain (VAS) after an appendectomy.https://jkmu.kmu.ac.ir/article_92377_750303d576a3ad47ad67fbc28629d1e9.pdfmelatoninpost-operative painappendectomy |
| spellingShingle | Alireza abdollahzadeh Baghaei Hashem Jarineshin Abbas Moallemy fereydoon Fekrat Mahla khoramvar Melatonin effect on Appendectomy Postoperative Pain: A Randomized Clinical Trial Journal of Kerman University of Medical Sciences melatonin post-operative pain appendectomy |
| title | Melatonin effect on Appendectomy Postoperative Pain: A Randomized Clinical Trial |
| title_full | Melatonin effect on Appendectomy Postoperative Pain: A Randomized Clinical Trial |
| title_fullStr | Melatonin effect on Appendectomy Postoperative Pain: A Randomized Clinical Trial |
| title_full_unstemmed | Melatonin effect on Appendectomy Postoperative Pain: A Randomized Clinical Trial |
| title_short | Melatonin effect on Appendectomy Postoperative Pain: A Randomized Clinical Trial |
| title_sort | melatonin effect on appendectomy postoperative pain a randomized clinical trial |
| topic | melatonin post-operative pain appendectomy |
| url | https://jkmu.kmu.ac.ir/article_92377_750303d576a3ad47ad67fbc28629d1e9.pdf |
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