Potential causal associations between perfluoroalkyl substances exposure and adverse pregnancy outcomes: A bidirectional two-sample mendelian randomization study
Maternal exposure to per- and polyfluoroalkyl substances (PFASs) has been linked to adverse pregnancy outcomes (APOs). Nonetheless, the genetic causality underlying this association remains unknown. This research employed a bidirectional two-sample Mendelian randomization (MR) to investigate the pot...
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Elsevier
2024-12-01
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| Series: | Ecotoxicology and Environmental Safety |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S0147651324014507 |
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| author | Yuanyuan Zhou Yujia Luo Yijie Lu Hangying Lou |
| author_facet | Yuanyuan Zhou Yujia Luo Yijie Lu Hangying Lou |
| author_sort | Yuanyuan Zhou |
| collection | DOAJ |
| description | Maternal exposure to per- and polyfluoroalkyl substances (PFASs) has been linked to adverse pregnancy outcomes (APOs). Nonetheless, the genetic causality underlying this association remains unknown. This research employed a bidirectional two-sample Mendelian randomization (MR) to investigate the potential causal associations between PFASs exposure and APOs risk. PFASs data were sourced from the GWAS Catalog, and APOs data were retrieved from the FinnGen consortium. Causal estimation primarily employed inverse variance weighting, with Cochran's Q test for instrumental variable heterogeneity, and MR-Egger, MR-PRESSO, and leave-one-out tests for sensitivity analyses. The possibility of reverse causality was investigated through reverse MR. MR evidence revealed a notable correlation between perfluorooctanoic acid (PFOA) and abruptio placentae (OR=1.498, P=0.026), as well as short gestation and low birth weight (OR=1.720, P=0.013). Exposure to perfluorooctanesulfonic acid (PFOS) increased the risk of preeclampsia or eclampsia (OR=1.128, P=0.030) and gestational hypertension (OR=1.076, P=0.049), but decreased the risk of premature rupture of membranes (OR=0.916, P=0.033). The results obtained were consistent across various sensitivity analyses. Reverse MR results was negative. These findings may provide a reference for prevention strategies and intervention measures for PFASs exposure and APOs, and provide a framework for studying the causal effects of environmental pollutant exposure and human diseases. |
| format | Article |
| id | doaj-art-e888616ee75f4990a4a1346f31975339 |
| institution | OA Journals |
| issn | 0147-6513 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Elsevier |
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| series | Ecotoxicology and Environmental Safety |
| spelling | doaj-art-e888616ee75f4990a4a1346f319753392025-08-20T02:21:04ZengElsevierEcotoxicology and Environmental Safety0147-65132024-12-0128811737410.1016/j.ecoenv.2024.117374Potential causal associations between perfluoroalkyl substances exposure and adverse pregnancy outcomes: A bidirectional two-sample mendelian randomization studyYuanyuan Zhou0Yujia Luo1Yijie Lu2Hangying Lou3Department of Reproductive Endocrinology, Women’s Hospital, School of Medicine, Zhejiang University, Hangzhou, ChinaDepartment of NICU, Sir Run Run Shaw Hospital, School of Medicine, Zhejiang University, Hangzhou, ChinaWenzhou Medical University, Wenzhou, ChinaDepartment of Reproductive Endocrinology, Women’s Hospital, School of Medicine, Zhejiang University, Hangzhou, China; Corresponding author.Maternal exposure to per- and polyfluoroalkyl substances (PFASs) has been linked to adverse pregnancy outcomes (APOs). Nonetheless, the genetic causality underlying this association remains unknown. This research employed a bidirectional two-sample Mendelian randomization (MR) to investigate the potential causal associations between PFASs exposure and APOs risk. PFASs data were sourced from the GWAS Catalog, and APOs data were retrieved from the FinnGen consortium. Causal estimation primarily employed inverse variance weighting, with Cochran's Q test for instrumental variable heterogeneity, and MR-Egger, MR-PRESSO, and leave-one-out tests for sensitivity analyses. The possibility of reverse causality was investigated through reverse MR. MR evidence revealed a notable correlation between perfluorooctanoic acid (PFOA) and abruptio placentae (OR=1.498, P=0.026), as well as short gestation and low birth weight (OR=1.720, P=0.013). Exposure to perfluorooctanesulfonic acid (PFOS) increased the risk of preeclampsia or eclampsia (OR=1.128, P=0.030) and gestational hypertension (OR=1.076, P=0.049), but decreased the risk of premature rupture of membranes (OR=0.916, P=0.033). The results obtained were consistent across various sensitivity analyses. Reverse MR results was negative. These findings may provide a reference for prevention strategies and intervention measures for PFASs exposure and APOs, and provide a framework for studying the causal effects of environmental pollutant exposure and human diseases.http://www.sciencedirect.com/science/article/pii/S0147651324014507Per- and polyfluoroalkyl substancesPerfluorooctanoic acidPerfluorooctanesulfonic acidAdverse pregnancy outcomesCausalityMendelian randomization |
| spellingShingle | Yuanyuan Zhou Yujia Luo Yijie Lu Hangying Lou Potential causal associations between perfluoroalkyl substances exposure and adverse pregnancy outcomes: A bidirectional two-sample mendelian randomization study Ecotoxicology and Environmental Safety Per- and polyfluoroalkyl substances Perfluorooctanoic acid Perfluorooctanesulfonic acid Adverse pregnancy outcomes Causality Mendelian randomization |
| title | Potential causal associations between perfluoroalkyl substances exposure and adverse pregnancy outcomes: A bidirectional two-sample mendelian randomization study |
| title_full | Potential causal associations between perfluoroalkyl substances exposure and adverse pregnancy outcomes: A bidirectional two-sample mendelian randomization study |
| title_fullStr | Potential causal associations between perfluoroalkyl substances exposure and adverse pregnancy outcomes: A bidirectional two-sample mendelian randomization study |
| title_full_unstemmed | Potential causal associations between perfluoroalkyl substances exposure and adverse pregnancy outcomes: A bidirectional two-sample mendelian randomization study |
| title_short | Potential causal associations between perfluoroalkyl substances exposure and adverse pregnancy outcomes: A bidirectional two-sample mendelian randomization study |
| title_sort | potential causal associations between perfluoroalkyl substances exposure and adverse pregnancy outcomes a bidirectional two sample mendelian randomization study |
| topic | Per- and polyfluoroalkyl substances Perfluorooctanoic acid Perfluorooctanesulfonic acid Adverse pregnancy outcomes Causality Mendelian randomization |
| url | http://www.sciencedirect.com/science/article/pii/S0147651324014507 |
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