Functional condition of vascular endothelium in patients with coronary heart disease in combination with non-alcoholic fatty liver disease, depending on weight and influence of statin therapy
Aim. 28 Patients have been observed to examine correlation between functional condition of vascular endothelium, and weight in patients with coronary heart disease in combination with non-alcoholic fatty liver disease and also its dynamics under influence of statin therapy. Methods and results. I...
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Zaporizhzhia State Medical and Pharmaceutical University
2015-02-01
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| Series: | Zaporožskij Medicinskij Žurnal |
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| Online Access: | http://zmj.zsmu.edu.ua/article/view/38626/34994 |
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| author | O. V. Kuryata M. M. Grechanyk |
| author_facet | O. V. Kuryata M. M. Grechanyk |
| author_sort | O. V. Kuryata |
| collection | DOAJ |
| description | Aim. 28 Patients have been observed to examine correlation between functional condition of vascular endothelium, and weight in patients with coronary heart disease in combination with non-alcoholic fatty liver disease and also its dynamics under influence of statin therapy.
Methods and results. In 20 patients endothelium-dependent vasodilation (EDVD) has been detected based on reactive hyperemia and its dynamics depending on the body mass index under the influence of statin therapy.
Conclusion. In patients with ischemic heart disease, obesity and NAFLD first degree expressed positive dynamics on endothelial function (57%) in contrast to patients with overweight (44%) has been revealed during therapy with pitavastatin 2 mg for 8 weeks; besides an increase of hepatic transaminases has not been detected, which means that the abolition of the drug was not required. |
| format | Article |
| id | doaj-art-e8843062903147cda33ccdd3c5696865 |
| institution | DOAJ |
| issn | 2306-4145 2310-1210 |
| language | English |
| publishDate | 2015-02-01 |
| publisher | Zaporizhzhia State Medical and Pharmaceutical University |
| record_format | Article |
| series | Zaporožskij Medicinskij Žurnal |
| spelling | doaj-art-e8843062903147cda33ccdd3c56968652025-08-20T03:21:02ZengZaporizhzhia State Medical and Pharmaceutical UniversityZaporožskij Medicinskij Žurnal2306-41452310-12102015-02-0111419http://dx.doi.org/10.14739/2310-1210.2015.1.38626Functional condition of vascular endothelium in patients with coronary heart disease in combination with non-alcoholic fatty liver disease, depending on weight and influence of statin therapyO. V. KuryataM. M. GrechanykAim. 28 Patients have been observed to examine correlation between functional condition of vascular endothelium, and weight in patients with coronary heart disease in combination with non-alcoholic fatty liver disease and also its dynamics under influence of statin therapy. Methods and results. In 20 patients endothelium-dependent vasodilation (EDVD) has been detected based on reactive hyperemia and its dynamics depending on the body mass index under the influence of statin therapy. Conclusion. In patients with ischemic heart disease, obesity and NAFLD first degree expressed positive dynamics on endothelial function (57%) in contrast to patients with overweight (44%) has been revealed during therapy with pitavastatin 2 mg for 8 weeks; besides an increase of hepatic transaminases has not been detected, which means that the abolition of the drug was not required.http://zmj.zsmu.edu.ua/article/view/38626/34994Myocardial IschemiaNon-alcoholic Fatty Liver DiseaseVascular Endothelium |
| spellingShingle | O. V. Kuryata M. M. Grechanyk Functional condition of vascular endothelium in patients with coronary heart disease in combination with non-alcoholic fatty liver disease, depending on weight and influence of statin therapy Zaporožskij Medicinskij Žurnal Myocardial Ischemia Non-alcoholic Fatty Liver Disease Vascular Endothelium |
| title | Functional condition of vascular endothelium in patients with coronary heart disease in combination with non-alcoholic fatty liver disease, depending on weight and influence of statin therapy |
| title_full | Functional condition of vascular endothelium in patients with coronary heart disease in combination with non-alcoholic fatty liver disease, depending on weight and influence of statin therapy |
| title_fullStr | Functional condition of vascular endothelium in patients with coronary heart disease in combination with non-alcoholic fatty liver disease, depending on weight and influence of statin therapy |
| title_full_unstemmed | Functional condition of vascular endothelium in patients with coronary heart disease in combination with non-alcoholic fatty liver disease, depending on weight and influence of statin therapy |
| title_short | Functional condition of vascular endothelium in patients with coronary heart disease in combination with non-alcoholic fatty liver disease, depending on weight and influence of statin therapy |
| title_sort | functional condition of vascular endothelium in patients with coronary heart disease in combination with non alcoholic fatty liver disease depending on weight and influence of statin therapy |
| topic | Myocardial Ischemia Non-alcoholic Fatty Liver Disease Vascular Endothelium |
| url | http://zmj.zsmu.edu.ua/article/view/38626/34994 |
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