The research progress into cellular mechanosensitive ion channels mediating cancer pain
Cellular mechanotransduction refers to the process through which cells perceive mechanical stimuli and subsequently translate them into biochemical signals. Key mechanosensitive ion channels encompass PIEZO, TREK-1, and TRESK. These mechanosensitive ion channels are crucial in regulating specific pa...
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| Language: | English |
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Taylor & Francis Group
2025-12-01
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| Online Access: | https://www.tandfonline.com/doi/10.1080/19336950.2025.2517109 |
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| author | Chang Liu Haiyan Li Lihua Hang |
| author_facet | Chang Liu Haiyan Li Lihua Hang |
| author_sort | Chang Liu |
| collection | DOAJ |
| description | Cellular mechanotransduction refers to the process through which cells perceive mechanical stimuli and subsequently translate them into biochemical signals. Key mechanosensitive ion channels encompass PIEZO, TREK-1, and TRESK. These mechanosensitive ion channels are crucial in regulating specific pathophysiological conditions, including fibrosis, tumor progression, and cellular proliferation and differentiation. Recent research indicates that PIEZO, TREK-1, and TRESK are significant contributors to various types of cancer pain by sensing mechanical stimuli, which subsequently activate internal signaling pathways. Here concentrates on advancements in research concerning PIEZO, TREK-1, and TRESK in cancer pain research, aiming to lay the groundwork for creating new therapeutic drugs that address mechanosensitive ion channels for treating cancer pain. |
| format | Article |
| id | doaj-art-e881f900bcdd4aeeae91eeff2932907d |
| institution | Kabale University |
| issn | 1933-6950 1933-6969 |
| language | English |
| publishDate | 2025-12-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Channels |
| spelling | doaj-art-e881f900bcdd4aeeae91eeff2932907d2025-08-20T03:45:10ZengTaylor & Francis GroupChannels1933-69501933-69692025-12-0119110.1080/19336950.2025.2517109The research progress into cellular mechanosensitive ion channels mediating cancer painChang Liu0Haiyan Li1Lihua Hang2Gusu School, Nanjing Medical University, The First People’s Hospital of Kunshan, Suzhou, ChinaDepartment of Anesthesiology, Kunshan Hospital Affiliated to Jiangsu University & Kunshan Cancer Pain Prevention and Treatment Key Laboratory, Suzhou, ChinaGusu School, Nanjing Medical University, The First People’s Hospital of Kunshan, Suzhou, ChinaCellular mechanotransduction refers to the process through which cells perceive mechanical stimuli and subsequently translate them into biochemical signals. Key mechanosensitive ion channels encompass PIEZO, TREK-1, and TRESK. These mechanosensitive ion channels are crucial in regulating specific pathophysiological conditions, including fibrosis, tumor progression, and cellular proliferation and differentiation. Recent research indicates that PIEZO, TREK-1, and TRESK are significant contributors to various types of cancer pain by sensing mechanical stimuli, which subsequently activate internal signaling pathways. Here concentrates on advancements in research concerning PIEZO, TREK-1, and TRESK in cancer pain research, aiming to lay the groundwork for creating new therapeutic drugs that address mechanosensitive ion channels for treating cancer pain.https://www.tandfonline.com/doi/10.1080/19336950.2025.2517109PIEZOTREK-1TRESKcancer painmechanosensitive ion channels |
| spellingShingle | Chang Liu Haiyan Li Lihua Hang The research progress into cellular mechanosensitive ion channels mediating cancer pain Channels PIEZO TREK-1 TRESK cancer pain mechanosensitive ion channels |
| title | The research progress into cellular mechanosensitive ion channels mediating cancer pain |
| title_full | The research progress into cellular mechanosensitive ion channels mediating cancer pain |
| title_fullStr | The research progress into cellular mechanosensitive ion channels mediating cancer pain |
| title_full_unstemmed | The research progress into cellular mechanosensitive ion channels mediating cancer pain |
| title_short | The research progress into cellular mechanosensitive ion channels mediating cancer pain |
| title_sort | research progress into cellular mechanosensitive ion channels mediating cancer pain |
| topic | PIEZO TREK-1 TRESK cancer pain mechanosensitive ion channels |
| url | https://www.tandfonline.com/doi/10.1080/19336950.2025.2517109 |
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