Disparities in health-related quality of life between patients with primary and secondary antibody deficiencies
Background: The impact and burden of antibody deficiencies, especially secondary antibody deficiency (SAD), among adult patients remain largely understudied. Specifically, the health-related quality of life (HRQoL) of patients with SAD, compared to patients with primary antibody deficiency (PAD) rem...
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Elsevier
2025-08-01
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| Series: | Journal of Allergy and Clinical Immunology: Global |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2772829325001079 |
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| author | Andy Ka Chun Kan, MBBS (Hons), MRes Valerie Chiang, MBBS Elaine Y.L. Au, MBBS, FRCPA Chak Sing Lau, MD (Hons), FRCP Philip H. Li, MD, FRCP, FRCPath, FAAAAI |
| author_facet | Andy Ka Chun Kan, MBBS (Hons), MRes Valerie Chiang, MBBS Elaine Y.L. Au, MBBS, FRCPA Chak Sing Lau, MD (Hons), FRCP Philip H. Li, MD, FRCP, FRCPath, FAAAAI |
| author_sort | Andy Ka Chun Kan, MBBS (Hons), MRes |
| collection | DOAJ |
| description | Background: The impact and burden of antibody deficiencies, especially secondary antibody deficiency (SAD), among adult patients remain largely understudied. Specifically, the health-related quality of life (HRQoL) of patients with SAD, compared to patients with primary antibody deficiency (PAD) remains unknown. Objective: Our aim was to characterize and compare the HRQoL of adult patients diagnosed with PAD and SAD. Methods: Clinical and HRQoL questionnaire survey data (from the SF-36v2 Health Survey [SF-36v2]) of all adult patients diagnosed with PAD or SAD at Queen Mary Hospital (the only adult immunology center in Hong Kong) were analyzed and compared to data on the general population. Results: Among the 33 adult patients with antibody deficiency, 22 (66.7%) and 11 (33.3%) had PAD and SAD, respectively. Compared to the general population, patients with PAD scored significantly lower in 3 of 8 domains of the SF-36v2, namely, Role-Physical (81.0 vs 90.4 [P = .020]), Bodily Pain (70.6 vs 84.0 [P = .013]), and Social Functioning (80.1 vs 91.2 [P = .024]). In comparison, patients with SAD scored significantly lower HRQoL in 5 of 8 domains of the SF-36v2, namely, Physical Functioning (64.1 vs 91.8 [P = .032]), Role-Physical (61.9 vs 90.4 [P = .018]), Bodily Pain (51.6 vs 84.0 [P = .003]), General Health (32.9 vs 56.0 [P = .006]), and Social Functioning (61.4 vs 91.2 [P = .027]), as well as in the Physical Component Summary (41.7 vs 53.0 [P = .004]). Upon direct comparison with patients with PAD, patients with SAD had significantly poorer HRQoL in the Physical Component Summary (41.7 vs 49.9 [P = .015]). Conclusion: Patients with SAD reported significantly poorer HRQoL than patients with PAD. Despite significantly greater impairment in HRQoL, patients with SAD often remain underrepresented and may warrant particular attention in terms of physical support and resource allocation. |
| format | Article |
| id | doaj-art-e88034d987c642b3affdb437ccf11649 |
| institution | DOAJ |
| issn | 2772-8293 |
| language | English |
| publishDate | 2025-08-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Journal of Allergy and Clinical Immunology: Global |
| spelling | doaj-art-e88034d987c642b3affdb437ccf116492025-08-20T03:18:38ZengElsevierJournal of Allergy and Clinical Immunology: Global2772-82932025-08-014310050610.1016/j.jacig.2025.100506Disparities in health-related quality of life between patients with primary and secondary antibody deficienciesAndy Ka Chun Kan, MBBS (Hons), MRes0Valerie Chiang, MBBS1Elaine Y.L. Au, MBBS, FRCPA2Chak Sing Lau, MD (Hons), FRCP3Philip H. Li, MD, FRCP, FRCPath, FAAAAI4Division of Rheumatology and Clinical Immunology, Department of Medicine, Queen Mary Hospital, The University of Hong Kong, Hong KongDivision of Clinical Immunology, Department of Pathology, Queen Mary Hospital, Hong KongDivision of Clinical Immunology, Department of Pathology, Queen Mary Hospital, Hong KongDivision of Rheumatology and Clinical Immunology, Department of Medicine, Queen Mary Hospital, The University of Hong Kong, Hong KongDivision of Rheumatology and Clinical Immunology, Department of Medicine, Queen Mary Hospital, The University of Hong Kong, Hong Kong; Corresponding author: Philip H. Li, MD, FRCP, FRCPath, FAAAAI, Division of Rheumatology and Clinical Immunology, Department of Medicine, The University of Hong Kong, Queen Mary Hospital, 102 Pokfulam Road, Pokfulam, Hong Kong.Background: The impact and burden of antibody deficiencies, especially secondary antibody deficiency (SAD), among adult patients remain largely understudied. Specifically, the health-related quality of life (HRQoL) of patients with SAD, compared to patients with primary antibody deficiency (PAD) remains unknown. Objective: Our aim was to characterize and compare the HRQoL of adult patients diagnosed with PAD and SAD. Methods: Clinical and HRQoL questionnaire survey data (from the SF-36v2 Health Survey [SF-36v2]) of all adult patients diagnosed with PAD or SAD at Queen Mary Hospital (the only adult immunology center in Hong Kong) were analyzed and compared to data on the general population. Results: Among the 33 adult patients with antibody deficiency, 22 (66.7%) and 11 (33.3%) had PAD and SAD, respectively. Compared to the general population, patients with PAD scored significantly lower in 3 of 8 domains of the SF-36v2, namely, Role-Physical (81.0 vs 90.4 [P = .020]), Bodily Pain (70.6 vs 84.0 [P = .013]), and Social Functioning (80.1 vs 91.2 [P = .024]). In comparison, patients with SAD scored significantly lower HRQoL in 5 of 8 domains of the SF-36v2, namely, Physical Functioning (64.1 vs 91.8 [P = .032]), Role-Physical (61.9 vs 90.4 [P = .018]), Bodily Pain (51.6 vs 84.0 [P = .003]), General Health (32.9 vs 56.0 [P = .006]), and Social Functioning (61.4 vs 91.2 [P = .027]), as well as in the Physical Component Summary (41.7 vs 53.0 [P = .004]). Upon direct comparison with patients with PAD, patients with SAD had significantly poorer HRQoL in the Physical Component Summary (41.7 vs 49.9 [P = .015]). Conclusion: Patients with SAD reported significantly poorer HRQoL than patients with PAD. Despite significantly greater impairment in HRQoL, patients with SAD often remain underrepresented and may warrant particular attention in terms of physical support and resource allocation.http://www.sciencedirect.com/science/article/pii/S2772829325001079Primary antibody deficiencysecondary antibody deficiencyimmunodeficiencyquality of lifeSF-36v2immunoglobulin therapy |
| spellingShingle | Andy Ka Chun Kan, MBBS (Hons), MRes Valerie Chiang, MBBS Elaine Y.L. Au, MBBS, FRCPA Chak Sing Lau, MD (Hons), FRCP Philip H. Li, MD, FRCP, FRCPath, FAAAAI Disparities in health-related quality of life between patients with primary and secondary antibody deficiencies Journal of Allergy and Clinical Immunology: Global Primary antibody deficiency secondary antibody deficiency immunodeficiency quality of life SF-36v2 immunoglobulin therapy |
| title | Disparities in health-related quality of life between patients with primary and secondary antibody deficiencies |
| title_full | Disparities in health-related quality of life between patients with primary and secondary antibody deficiencies |
| title_fullStr | Disparities in health-related quality of life between patients with primary and secondary antibody deficiencies |
| title_full_unstemmed | Disparities in health-related quality of life between patients with primary and secondary antibody deficiencies |
| title_short | Disparities in health-related quality of life between patients with primary and secondary antibody deficiencies |
| title_sort | disparities in health related quality of life between patients with primary and secondary antibody deficiencies |
| topic | Primary antibody deficiency secondary antibody deficiency immunodeficiency quality of life SF-36v2 immunoglobulin therapy |
| url | http://www.sciencedirect.com/science/article/pii/S2772829325001079 |
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