Rapidly Progressive Bilateral Leg Weakness in a 65-Year-Old Man: A Case Report
Paraneoplastic neurological syndromes can affect any part of the nervous system, often have a stereotypical presentation, occur in association with a tumor, and have an antibody-mediated pathogenesis. We describe the case of a 65-year-old previously healthy crane operator who presented to the emerge...
Saved in:
| Main Authors: | , , |
|---|---|
| Format: | Article |
| Language: | deu |
| Published: |
THE HEALTHBOOK COMPANY LTD.
2025-03-01
|
| Series: | healthbook TIMES Das Schweizer Ärztejournal Journal Des Médecins Suisses |
| Online Access: | https://doi.org/10.36000/hbT.2025.16.003 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1849414907870576640 |
|---|---|
| author | Simona Jahnke Monika Atiya Jean-Luc Kurzen |
| author_facet | Simona Jahnke Monika Atiya Jean-Luc Kurzen |
| author_sort | Simona Jahnke |
| collection | DOAJ |
| description | Paraneoplastic neurological syndromes can affect any part of the nervous system, often have a stereotypical presentation, occur in association with a tumor, and have an antibody-mediated pathogenesis.
We describe the case of a 65-year-old previously healthy crane operator who presented to the emergency department due to symmetrical, gradually progressive gait instability and leg weakness. Due to evidence of a pulmonary mass in combination with polyneuroradiculopathy, a thoracoscopic upper lobe resection was performed with histological findings of an adenocarcinoma. Postoperatively, there was a marked improvement in gait and distal paraparesis. Despite an extensive search, no paraneoplastic autoantibodies could be detected in our patient. According to the 2021 consensus criteria, both the clinical phenotype and the presence of a tumor, as well as the determination of anti-neuronal antibodies in serum and cerebrospinal fluid, are essential for diagnosis. This enables a diagnosis to be made in four categories (definite, probable, possible, non-paraneoplastic neurological syndrome [PNS]).
PEER REVIEWED ARTICLE
Peer Reviewers:
Prof. Dr Uwe Schlegel, Klinik für Neurologie Hirslanden, Zurich, und Neurozentrum Bellevue, Zurich
One anonymous peer reviewer
Received on January 25, 2025; accepted after peer review on February 27, 2025; published on March 17, 2025. |
| format | Article |
| id | doaj-art-e87f96d4848b40ca88b9f3b2a5889345 |
| institution | Kabale University |
| issn | 2673-8406 2673-8414 |
| language | deu |
| publishDate | 2025-03-01 |
| publisher | THE HEALTHBOOK COMPANY LTD. |
| record_format | Article |
| series | healthbook TIMES Das Schweizer Ärztejournal Journal Des Médecins Suisses |
| spelling | doaj-art-e87f96d4848b40ca88b9f3b2a58893452025-08-20T03:33:41ZdeuTHE HEALTHBOOK COMPANY LTD.healthbook TIMES Das Schweizer Ärztejournal Journal Des Médecins Suisses2673-84062673-84142025-03-0116110.36000/hbT.2025.16.003Rapidly Progressive Bilateral Leg Weakness in a 65-Year-Old Man: A Case ReportSimona JahnkeMonika AtiyaJean-Luc KurzenParaneoplastic neurological syndromes can affect any part of the nervous system, often have a stereotypical presentation, occur in association with a tumor, and have an antibody-mediated pathogenesis. We describe the case of a 65-year-old previously healthy crane operator who presented to the emergency department due to symmetrical, gradually progressive gait instability and leg weakness. Due to evidence of a pulmonary mass in combination with polyneuroradiculopathy, a thoracoscopic upper lobe resection was performed with histological findings of an adenocarcinoma. Postoperatively, there was a marked improvement in gait and distal paraparesis. Despite an extensive search, no paraneoplastic autoantibodies could be detected in our patient. According to the 2021 consensus criteria, both the clinical phenotype and the presence of a tumor, as well as the determination of anti-neuronal antibodies in serum and cerebrospinal fluid, are essential for diagnosis. This enables a diagnosis to be made in four categories (definite, probable, possible, non-paraneoplastic neurological syndrome [PNS]). PEER REVIEWED ARTICLE Peer Reviewers: Prof. Dr Uwe Schlegel, Klinik für Neurologie Hirslanden, Zurich, und Neurozentrum Bellevue, Zurich One anonymous peer reviewer Received on January 25, 2025; accepted after peer review on February 27, 2025; published on March 17, 2025.https://doi.org/10.36000/hbT.2025.16.003 |
| spellingShingle | Simona Jahnke Monika Atiya Jean-Luc Kurzen Rapidly Progressive Bilateral Leg Weakness in a 65-Year-Old Man: A Case Report healthbook TIMES Das Schweizer Ärztejournal Journal Des Médecins Suisses |
| title | Rapidly Progressive Bilateral Leg Weakness in a 65-Year-Old Man: A Case Report |
| title_full | Rapidly Progressive Bilateral Leg Weakness in a 65-Year-Old Man: A Case Report |
| title_fullStr | Rapidly Progressive Bilateral Leg Weakness in a 65-Year-Old Man: A Case Report |
| title_full_unstemmed | Rapidly Progressive Bilateral Leg Weakness in a 65-Year-Old Man: A Case Report |
| title_short | Rapidly Progressive Bilateral Leg Weakness in a 65-Year-Old Man: A Case Report |
| title_sort | rapidly progressive bilateral leg weakness in a 65 year old man a case report |
| url | https://doi.org/10.36000/hbT.2025.16.003 |
| work_keys_str_mv | AT simonajahnke rapidlyprogressivebilaterallegweaknessina65yearoldmanacasereport AT monikaatiya rapidlyprogressivebilaterallegweaknessina65yearoldmanacasereport AT jeanluckurzen rapidlyprogressivebilaterallegweaknessina65yearoldmanacasereport |