Diagnosis of Obstructive Sleep Apnea in Parkinson’s Disease Patients: Is Unattended Portable Monitoring a Suitable Tool?
Purpose. Obstructive sleep apnea (OSA) is frequent in Parkinson’s disease (PD) and may contribute to nonmotor symptoms. Polysomnography (PSG) is the gold standard for OSA diagnosis. Unattended portable monitoring (PM) may improve access to diagnosis but has not been studied in PD. We assessed feasib...
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| Format: | Article |
| Language: | English |
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Wiley
2015-01-01
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| Series: | Parkinson's Disease |
| Online Access: | http://dx.doi.org/10.1155/2015/258418 |
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| author | Priti Gros Victoria P. Mery Anne-Louise Lafontaine Ann Robinson Andrea Benedetti R. John Kimoff Marta Kaminska |
| author_facet | Priti Gros Victoria P. Mery Anne-Louise Lafontaine Ann Robinson Andrea Benedetti R. John Kimoff Marta Kaminska |
| author_sort | Priti Gros |
| collection | DOAJ |
| description | Purpose. Obstructive sleep apnea (OSA) is frequent in Parkinson’s disease (PD) and may contribute to nonmotor symptoms. Polysomnography (PSG) is the gold standard for OSA diagnosis. Unattended portable monitoring (PM) may improve access to diagnosis but has not been studied in PD. We assessed feasibility and diagnostic accuracy in PD. Methods. Selected PD patients without known OSA underwent home PM and laboratory PSG. The quality of PM signals (n = 28) was compared with matched controls. PM accuracy was calculated compared with PSG for standard apnea hypopnea index (AHI) thresholds. Results. Technical failure rate was 27.0% and airflow signal quality was lower than in controls. Sensitivity of PM was 84.0%, 36.4%, and 50.0% for AHI cut-offs of 5/h, 15/h, and 30/h, respectively, using the same cut-offs on PM. Specificity was 66.7%, 83.3%, and 100%, respectively. PM underestimated the AHI with a mean bias of 12.4/h. Discrepancy between PM and PSG was greater in those with more motor dysfunction. Conclusion. PM was adequate to “rule in” moderate or severe OSA in PD patients, but the failure rate was relatively high and signal quality poorer than in controls. PM overall underestimated the severity of OSA in PD patients, especially those with greater motor dysfunction. |
| format | Article |
| id | doaj-art-e87a61b9b25343d88d9faa84c964e66d |
| institution | Kabale University |
| issn | 2090-8083 2042-0080 |
| language | English |
| publishDate | 2015-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Parkinson's Disease |
| spelling | doaj-art-e87a61b9b25343d88d9faa84c964e66d2025-02-03T01:12:37ZengWileyParkinson's Disease2090-80832042-00802015-01-01201510.1155/2015/258418258418Diagnosis of Obstructive Sleep Apnea in Parkinson’s Disease Patients: Is Unattended Portable Monitoring a Suitable Tool?Priti Gros0Victoria P. Mery1Anne-Louise Lafontaine2Ann Robinson3Andrea Benedetti4R. John Kimoff5Marta Kaminska6Respiratory Division and Sleep Laboratory, McGill University Health Centre, Montreal, QC, H4A 3J1, CanadaClinica Alemana de Santiago, Facultad de Medicina Clinica Alemana, Universidad del Desarrollo, Santiago, ChileMontreal Neurological Hospital, McGill University Centre, Montreal, QC, H3A 2B4, CanadaRespiratory Division and Sleep Laboratory, McGill University Health Centre, Montreal, QC, H4A 3J1, CanadaDepartment of Medicine and Department of Epidemiology, Biostatistics & Occupational Health, McGill University Health Centre, Montreal, QC, H4A 3J1, CanadaRespiratory Division and Sleep Laboratory, McGill University Health Centre, Montreal, QC, H4A 3J1, CanadaRespiratory Division and Sleep Laboratory, McGill University Health Centre, Montreal, QC, H4A 3J1, CanadaPurpose. Obstructive sleep apnea (OSA) is frequent in Parkinson’s disease (PD) and may contribute to nonmotor symptoms. Polysomnography (PSG) is the gold standard for OSA diagnosis. Unattended portable monitoring (PM) may improve access to diagnosis but has not been studied in PD. We assessed feasibility and diagnostic accuracy in PD. Methods. Selected PD patients without known OSA underwent home PM and laboratory PSG. The quality of PM signals (n = 28) was compared with matched controls. PM accuracy was calculated compared with PSG for standard apnea hypopnea index (AHI) thresholds. Results. Technical failure rate was 27.0% and airflow signal quality was lower than in controls. Sensitivity of PM was 84.0%, 36.4%, and 50.0% for AHI cut-offs of 5/h, 15/h, and 30/h, respectively, using the same cut-offs on PM. Specificity was 66.7%, 83.3%, and 100%, respectively. PM underestimated the AHI with a mean bias of 12.4/h. Discrepancy between PM and PSG was greater in those with more motor dysfunction. Conclusion. PM was adequate to “rule in” moderate or severe OSA in PD patients, but the failure rate was relatively high and signal quality poorer than in controls. PM overall underestimated the severity of OSA in PD patients, especially those with greater motor dysfunction.http://dx.doi.org/10.1155/2015/258418 |
| spellingShingle | Priti Gros Victoria P. Mery Anne-Louise Lafontaine Ann Robinson Andrea Benedetti R. John Kimoff Marta Kaminska Diagnosis of Obstructive Sleep Apnea in Parkinson’s Disease Patients: Is Unattended Portable Monitoring a Suitable Tool? Parkinson's Disease |
| title | Diagnosis of Obstructive Sleep Apnea in Parkinson’s Disease Patients: Is Unattended Portable Monitoring a Suitable Tool? |
| title_full | Diagnosis of Obstructive Sleep Apnea in Parkinson’s Disease Patients: Is Unattended Portable Monitoring a Suitable Tool? |
| title_fullStr | Diagnosis of Obstructive Sleep Apnea in Parkinson’s Disease Patients: Is Unattended Portable Monitoring a Suitable Tool? |
| title_full_unstemmed | Diagnosis of Obstructive Sleep Apnea in Parkinson’s Disease Patients: Is Unattended Portable Monitoring a Suitable Tool? |
| title_short | Diagnosis of Obstructive Sleep Apnea in Parkinson’s Disease Patients: Is Unattended Portable Monitoring a Suitable Tool? |
| title_sort | diagnosis of obstructive sleep apnea in parkinson s disease patients is unattended portable monitoring a suitable tool |
| url | http://dx.doi.org/10.1155/2015/258418 |
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