Hematological Indices of Sickle Cell Anaemia Patients with Pulmonary Tuberculosis in Northern Nigeria.
Nigeria has the fourth highest prevalence of TB and the highest prevalence of Sickle cell anaemia (SCA) in the world. SCA patients have impaired immunity and are vulnerable to TB. Hence, we studied the haematological indices of SCA patients with TB in Nigeria. A total of 23 SCA patients with TB were...
Saved in:
| Main Authors: | , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
PAGEPress Publications
2010-06-01
|
| Series: | Mediterranean Journal of Hematology and Infectious Diseases |
| Subjects: | |
| Online Access: | http://www.mjhid.org/index.php/mjhid/article/view/164 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1850283442342723584 |
|---|---|
| author | Sagir G. Ahmed Audu A. Bukar Bashir Jolayemi |
| author_facet | Sagir G. Ahmed Audu A. Bukar Bashir Jolayemi |
| author_sort | Sagir G. Ahmed |
| collection | DOAJ |
| description | Nigeria has the fourth highest prevalence of TB and the highest prevalence of Sickle cell anaemia (SCA) in the world. SCA patients have impaired immunity and are vulnerable to TB. Hence, we studied the haematological indices of SCA patients with TB in Nigeria. A total of 23 SCA patients with TB were studied in parallel with equal number of age and sex matched SCA patients without TB. SCA patients with TB had significantly lower haematocrit, higher level of circulating sickle cells (CSCs) and similar level of reticulocyte count in comparison to patients without TB. SCA patients with TB had significantly higher mean WBC count associated with higher frequency of neutrophilia in comparison to those without TB. Monocytosis and eosinopenia were exclusively found in SCA patients with TB at frequencies of 52% and 65% respectively. Lymphocyte and basophil counts were normal in all patients with and without TB. Mean platelet counts were high in both patient groups but the frequency of thrombocytosis was significantly higher in patients with TB. SCA patients with TB had significantly higher mean ESR than their counterparts without the infection. The findings of this study revealed that TB in SCA patients was associated with rising level of CSCs, falling level of haematocrit, sub-optimal reticulocytosis, neutrophilia, monocytosis, thrombocytosis, eosinopenia and rising level of ESR. Hence, SCA patients presenting with these haematological indices should be investigated for TB. |
| format | Article |
| id | doaj-art-e877ada98cb54101a44e0824783200f1 |
| institution | OA Journals |
| issn | 2035-3006 |
| language | English |
| publishDate | 2010-06-01 |
| publisher | PAGEPress Publications |
| record_format | Article |
| series | Mediterranean Journal of Hematology and Infectious Diseases |
| spelling | doaj-art-e877ada98cb54101a44e0824783200f12025-08-20T01:47:47ZengPAGEPress PublicationsMediterranean Journal of Hematology and Infectious Diseases2035-30062010-06-0121e2010014e201001410.4084/mjhid.2010.01457Hematological Indices of Sickle Cell Anaemia Patients with Pulmonary Tuberculosis in Northern Nigeria.Sagir G. Ahmed0Audu A. BukarBashir JolayemiDept of Haematology, Aminu Kano Teaching Hospital, PMB 3452, Kano, NigeriaNigeria has the fourth highest prevalence of TB and the highest prevalence of Sickle cell anaemia (SCA) in the world. SCA patients have impaired immunity and are vulnerable to TB. Hence, we studied the haematological indices of SCA patients with TB in Nigeria. A total of 23 SCA patients with TB were studied in parallel with equal number of age and sex matched SCA patients without TB. SCA patients with TB had significantly lower haematocrit, higher level of circulating sickle cells (CSCs) and similar level of reticulocyte count in comparison to patients without TB. SCA patients with TB had significantly higher mean WBC count associated with higher frequency of neutrophilia in comparison to those without TB. Monocytosis and eosinopenia were exclusively found in SCA patients with TB at frequencies of 52% and 65% respectively. Lymphocyte and basophil counts were normal in all patients with and without TB. Mean platelet counts were high in both patient groups but the frequency of thrombocytosis was significantly higher in patients with TB. SCA patients with TB had significantly higher mean ESR than their counterparts without the infection. The findings of this study revealed that TB in SCA patients was associated with rising level of CSCs, falling level of haematocrit, sub-optimal reticulocytosis, neutrophilia, monocytosis, thrombocytosis, eosinopenia and rising level of ESR. Hence, SCA patients presenting with these haematological indices should be investigated for TB.http://www.mjhid.org/index.php/mjhid/article/view/164sickleCellAnemiaTuberculosisHematologicalIndices |
| spellingShingle | Sagir G. Ahmed Audu A. Bukar Bashir Jolayemi Hematological Indices of Sickle Cell Anaemia Patients with Pulmonary Tuberculosis in Northern Nigeria. Mediterranean Journal of Hematology and Infectious Diseases sickle Cell Anemia Tuberculosis Hematological Indices |
| title | Hematological Indices of Sickle Cell Anaemia Patients with Pulmonary Tuberculosis in Northern Nigeria. |
| title_full | Hematological Indices of Sickle Cell Anaemia Patients with Pulmonary Tuberculosis in Northern Nigeria. |
| title_fullStr | Hematological Indices of Sickle Cell Anaemia Patients with Pulmonary Tuberculosis in Northern Nigeria. |
| title_full_unstemmed | Hematological Indices of Sickle Cell Anaemia Patients with Pulmonary Tuberculosis in Northern Nigeria. |
| title_short | Hematological Indices of Sickle Cell Anaemia Patients with Pulmonary Tuberculosis in Northern Nigeria. |
| title_sort | hematological indices of sickle cell anaemia patients with pulmonary tuberculosis in northern nigeria |
| topic | sickle Cell Anemia Tuberculosis Hematological Indices |
| url | http://www.mjhid.org/index.php/mjhid/article/view/164 |
| work_keys_str_mv | AT sagirgahmed hematologicalindicesofsicklecellanaemiapatientswithpulmonarytuberculosisinnorthernnigeria AT auduabukar hematologicalindicesofsicklecellanaemiapatientswithpulmonarytuberculosisinnorthernnigeria AT bashirjolayemi hematologicalindicesofsicklecellanaemiapatientswithpulmonarytuberculosisinnorthernnigeria |