A systematic review of metastatic lesions to the oral and maxillofacial regions among Japanese people
This review aimed to integrate the available data published in the literature on metastatic lesions in the oral and maxillofacial region (MOMR) and to produce an updated comprehensive analysis of its clinical characteristics, treatment, and prognosis. An electronic database search was conducted for...
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| Format: | Article |
| Language: | English |
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Elsevier
2025-12-01
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| Series: | Japanese Dental Science Review |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S1882761625000122 |
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| author | Seiji Asoda Takazumi Yasui Kenta Tanaka Katsuhiro Onizawa Hiromasa Kawana Taneaki Nakagawa |
| author_facet | Seiji Asoda Takazumi Yasui Kenta Tanaka Katsuhiro Onizawa Hiromasa Kawana Taneaki Nakagawa |
| author_sort | Seiji Asoda |
| collection | DOAJ |
| description | This review aimed to integrate the available data published in the literature on metastatic lesions in the oral and maxillofacial region (MOMR) and to produce an updated comprehensive analysis of its clinical characteristics, treatment, and prognosis. An electronic database search was conducted for articles concerning MOMR in Japan. The incidence and characteristics of MOMR were investigated, and the survival time was analyzed. This systematic review identified 211 studies, including 356 cases. There was a male predominance (n = 250/70.2 %) and the mean age at the diagnosis was 62.1 (range, 4–91) years old. The most common primary site was the lungs (n = 104/29.2 %). Oral metastasis sites were equally frequent in the jawbone (n = 182/51.1 %) and soft tissue (n = 174/48.9 %). Among these, the mandible and gingiva were the most common. The most common clinical presentation was a nodule (n = 317/90.3 %). The presence of metastases to other organs (P = 0.009) and uncontrolled primary lesions (P < 0.001) was associated with a shortened survival. This systematic review provides important insights into the clinical features, diagnosis, and treatment of MOMR in Japan and will assist clinicians in their appropriate management. |
| format | Article |
| id | doaj-art-e877673d5411445e838d7cb5efba9fe0 |
| institution | Kabale University |
| issn | 1882-7616 |
| language | English |
| publishDate | 2025-12-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Japanese Dental Science Review |
| spelling | doaj-art-e877673d5411445e838d7cb5efba9fe02025-08-20T03:32:01ZengElsevierJapanese Dental Science Review1882-76162025-12-016115516610.1016/j.jdsr.2025.06.001A systematic review of metastatic lesions to the oral and maxillofacial regions among Japanese peopleSeiji Asoda0Takazumi Yasui1Kenta Tanaka2Katsuhiro Onizawa3Hiromasa Kawana4Taneaki Nakagawa5Department of Dentistry and Oral Surgery, School of Medicine, Keio University, Tokyo, Japan; Correspondence to: Department of Dentistry and Oral Surgery, School of Medicine, Keio University, 35 Shinanomachi, Tokyo, Shinjyuku-ku 160-8582, Japan.Department of Dentistry and Oral Surgery, School of Medicine, Keio University, Tokyo, Japan; Department of Dentistry and Oral Surgery, Kawasaki Municipal Kawasaki Hospital, Kawasaki, JapanDepartment of Dentistry and Oral Surgery, School of Medicine, Keio University, Tokyo, JapanDepartment of Dentistry and Oral Surgery, Kawasaki Municipal Kawasaki Hospital, Kawasaki, JapanDepartment of Dentistry and Oral Surgery, School of Medicine, Keio University, Tokyo, Japan; Departmant of Oral and Maxillofacial Implantology, Kanagawa Dental University, Yokosuka, JapanDepartment of Dentistry and Oral Surgery, School of Medicine, Keio University, Tokyo, JapanThis review aimed to integrate the available data published in the literature on metastatic lesions in the oral and maxillofacial region (MOMR) and to produce an updated comprehensive analysis of its clinical characteristics, treatment, and prognosis. An electronic database search was conducted for articles concerning MOMR in Japan. The incidence and characteristics of MOMR were investigated, and the survival time was analyzed. This systematic review identified 211 studies, including 356 cases. There was a male predominance (n = 250/70.2 %) and the mean age at the diagnosis was 62.1 (range, 4–91) years old. The most common primary site was the lungs (n = 104/29.2 %). Oral metastasis sites were equally frequent in the jawbone (n = 182/51.1 %) and soft tissue (n = 174/48.9 %). Among these, the mandible and gingiva were the most common. The most common clinical presentation was a nodule (n = 317/90.3 %). The presence of metastases to other organs (P = 0.009) and uncontrolled primary lesions (P < 0.001) was associated with a shortened survival. This systematic review provides important insights into the clinical features, diagnosis, and treatment of MOMR in Japan and will assist clinicians in their appropriate management.http://www.sciencedirect.com/science/article/pii/S1882761625000122Neoplasm metastasisMouth neoplasmsGingival neoplasmsJaw neoplasmsTongue NeoplasmsHead and neck neoplasms |
| spellingShingle | Seiji Asoda Takazumi Yasui Kenta Tanaka Katsuhiro Onizawa Hiromasa Kawana Taneaki Nakagawa A systematic review of metastatic lesions to the oral and maxillofacial regions among Japanese people Japanese Dental Science Review Neoplasm metastasis Mouth neoplasms Gingival neoplasms Jaw neoplasms Tongue Neoplasms Head and neck neoplasms |
| title | A systematic review of metastatic lesions to the oral and maxillofacial regions among Japanese people |
| title_full | A systematic review of metastatic lesions to the oral and maxillofacial regions among Japanese people |
| title_fullStr | A systematic review of metastatic lesions to the oral and maxillofacial regions among Japanese people |
| title_full_unstemmed | A systematic review of metastatic lesions to the oral and maxillofacial regions among Japanese people |
| title_short | A systematic review of metastatic lesions to the oral and maxillofacial regions among Japanese people |
| title_sort | systematic review of metastatic lesions to the oral and maxillofacial regions among japanese people |
| topic | Neoplasm metastasis Mouth neoplasms Gingival neoplasms Jaw neoplasms Tongue Neoplasms Head and neck neoplasms |
| url | http://www.sciencedirect.com/science/article/pii/S1882761625000122 |
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