Neutrophils and Platelets as Key Players in the Pathogenesis of ANCA-Associated Vasculitis and Potential Sources of Disease Activity Biomarkers
Anti-neutrophil cytoplasmic antibodies (ANCA)-associated vasculitis (AAV) is a heterogeneous group of small-vessel vasculitides, characterized by the presence of antibodies binding to myeloperoxidase (MPO) and proteinase-3 (PR3) found in neutrophil granules. Apart from being the target of ANCA, neut...
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2025-07-01
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| author | Anna Drynda Marcin Surmiak Stanisława Bazan-Socha Katarzyna Wawrzycka-Adamczyk Mariusz Korkosz Jacek Musiał Krzysztof Wójcik |
| author_facet | Anna Drynda Marcin Surmiak Stanisława Bazan-Socha Katarzyna Wawrzycka-Adamczyk Mariusz Korkosz Jacek Musiał Krzysztof Wójcik |
| author_sort | Anna Drynda |
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| description | Anti-neutrophil cytoplasmic antibodies (ANCA)-associated vasculitis (AAV) is a heterogeneous group of small-vessel vasculitides, characterized by the presence of antibodies binding to myeloperoxidase (MPO) and proteinase-3 (PR3) found in neutrophil granules. Apart from being the target of ANCA, neutrophils actively contribute to the vicious cycle of inflammation and vascular damage in AAV. On the other hand, platelets have recently been recognized as essential for thrombosis and as inflammatory effectors that collaborate with neutrophils, reinforcing the generation of reactive oxygen species (ROS) and the formation of neutrophil extracellular traps (NETs) in those diseases. Neutrophils exhibit morphological and functional heterogeneity in AAV, reflecting the complexity of their contribution to disease pathogenesis. Since long-term immunosuppression may be related to serious infections and malignancies, there is an urgent need for reliable biomarkers of disease activity to optimize the management of AAV. This review summarizes the current understanding of the role of neutrophils and platelets in the pathogenesis of granulomatosis with polyangiitis (GPA) and microscopic polyangiitis (MPA), focusing on their crosstalk, and highlights the potential for identifying novel biomarkers relevant for predicting the disease course and its relapses. |
| format | Article |
| id | doaj-art-e872f4f345f241b18b3ee58cb5bd90ba |
| institution | Kabale University |
| issn | 2075-4418 |
| language | English |
| publishDate | 2025-07-01 |
| publisher | MDPI AG |
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| series | Diagnostics |
| spelling | doaj-art-e872f4f345f241b18b3ee58cb5bd90ba2025-08-20T03:36:26ZengMDPI AGDiagnostics2075-44182025-07-011515190510.3390/diagnostics15151905Neutrophils and Platelets as Key Players in the Pathogenesis of ANCA-Associated Vasculitis and Potential Sources of Disease Activity BiomarkersAnna Drynda0Marcin Surmiak1Stanisława Bazan-Socha2Katarzyna Wawrzycka-Adamczyk3Mariusz Korkosz4Jacek Musiał5Krzysztof Wójcik6Doctoral School of Medical Sciences and Health Sciences, Jagiellonian University Medical College, 31-530 Cracow, Poland2nd Department of Internal Medicine, Faculty of Medicine, Jagiellonian University Medical College, 30-688 Cracow, Poland2nd Department of Internal Medicine, Faculty of Medicine, Jagiellonian University Medical College, 30-688 Cracow, Poland2nd Department of Internal Medicine, Faculty of Medicine, Jagiellonian University Medical College, 30-688 Cracow, PolandDepartment of Rheumatology and Immunology, Jagiellonian University Medical College, 30-688 Cracow, Poland2nd Department of Internal Medicine, Faculty of Medicine, Jagiellonian University Medical College, 30-688 Cracow, Poland2nd Department of Internal Medicine, Faculty of Medicine, Jagiellonian University Medical College, 30-688 Cracow, PolandAnti-neutrophil cytoplasmic antibodies (ANCA)-associated vasculitis (AAV) is a heterogeneous group of small-vessel vasculitides, characterized by the presence of antibodies binding to myeloperoxidase (MPO) and proteinase-3 (PR3) found in neutrophil granules. Apart from being the target of ANCA, neutrophils actively contribute to the vicious cycle of inflammation and vascular damage in AAV. On the other hand, platelets have recently been recognized as essential for thrombosis and as inflammatory effectors that collaborate with neutrophils, reinforcing the generation of reactive oxygen species (ROS) and the formation of neutrophil extracellular traps (NETs) in those diseases. Neutrophils exhibit morphological and functional heterogeneity in AAV, reflecting the complexity of their contribution to disease pathogenesis. Since long-term immunosuppression may be related to serious infections and malignancies, there is an urgent need for reliable biomarkers of disease activity to optimize the management of AAV. This review summarizes the current understanding of the role of neutrophils and platelets in the pathogenesis of granulomatosis with polyangiitis (GPA) and microscopic polyangiitis (MPA), focusing on their crosstalk, and highlights the potential for identifying novel biomarkers relevant for predicting the disease course and its relapses.https://www.mdpi.com/2075-4418/15/15/1905ANCA-associated vasculitis (AAV)neutrophilsplateletsmyeloperoxidase (MPO)proteinase-3 (PR3)neutrophil extracellular traps (NETs) |
| spellingShingle | Anna Drynda Marcin Surmiak Stanisława Bazan-Socha Katarzyna Wawrzycka-Adamczyk Mariusz Korkosz Jacek Musiał Krzysztof Wójcik Neutrophils and Platelets as Key Players in the Pathogenesis of ANCA-Associated Vasculitis and Potential Sources of Disease Activity Biomarkers Diagnostics ANCA-associated vasculitis (AAV) neutrophils platelets myeloperoxidase (MPO) proteinase-3 (PR3) neutrophil extracellular traps (NETs) |
| title | Neutrophils and Platelets as Key Players in the Pathogenesis of ANCA-Associated Vasculitis and Potential Sources of Disease Activity Biomarkers |
| title_full | Neutrophils and Platelets as Key Players in the Pathogenesis of ANCA-Associated Vasculitis and Potential Sources of Disease Activity Biomarkers |
| title_fullStr | Neutrophils and Platelets as Key Players in the Pathogenesis of ANCA-Associated Vasculitis and Potential Sources of Disease Activity Biomarkers |
| title_full_unstemmed | Neutrophils and Platelets as Key Players in the Pathogenesis of ANCA-Associated Vasculitis and Potential Sources of Disease Activity Biomarkers |
| title_short | Neutrophils and Platelets as Key Players in the Pathogenesis of ANCA-Associated Vasculitis and Potential Sources of Disease Activity Biomarkers |
| title_sort | neutrophils and platelets as key players in the pathogenesis of anca associated vasculitis and potential sources of disease activity biomarkers |
| topic | ANCA-associated vasculitis (AAV) neutrophils platelets myeloperoxidase (MPO) proteinase-3 (PR3) neutrophil extracellular traps (NETs) |
| url | https://www.mdpi.com/2075-4418/15/15/1905 |
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