Functional polymorphism of the mu-opioid receptor gene (OPRM1) influences reinforcement learning in humans.
Previous reports on the functional effects (i.e., gain or loss of function), and phenotypic outcomes (e.g., changes in addiction vulnerability and stress response) of a commonly occurring functional single nucleotide polymorphism (SNP) of the mu-opioid receptor (OPRM1 A118G) have been inconsistent....
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| Format: | Article |
| Language: | English |
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Public Library of Science (PLoS)
2011-01-01
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| Series: | PLoS ONE |
| Online Access: | https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0024203&type=printable |
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| author | Mary R Lee Courtney L Gallen Xiaochu Zhang Colin A Hodgkinson David Goldman Elliot A Stein Christina S Barr |
| author_facet | Mary R Lee Courtney L Gallen Xiaochu Zhang Colin A Hodgkinson David Goldman Elliot A Stein Christina S Barr |
| author_sort | Mary R Lee |
| collection | DOAJ |
| description | Previous reports on the functional effects (i.e., gain or loss of function), and phenotypic outcomes (e.g., changes in addiction vulnerability and stress response) of a commonly occurring functional single nucleotide polymorphism (SNP) of the mu-opioid receptor (OPRM1 A118G) have been inconsistent. Here we examine the effect of this polymorphism on implicit reward learning. We used a probabilistic signal detection task to determine whether this polymorphism impacts response bias to monetary reward in 63 healthy adult subjects: 51 AA homozygotes and 12 G allele carriers. OPRM1 AA homozygotes exhibited typical responding to the rewarded response--that is, their bias to the rewarded stimulus increased over time. However, OPRM1 G allele carriers exhibited a decline in response to the rewarded stimulus compared to the AA homozygotes. These results extend previous reports on the heritability of performance on this task by implicating a specific polymorphism. Through comparison with other studies using this task, we suggest a possible mechanism by which the OPRM1 polymorphism may confer reduced response to natural reward through a dopamine-mediated decrease during positive reinforcement learning. |
| format | Article |
| id | doaj-art-e870ff66676d4b4b8a60ea7ffd24f2bd |
| institution | OA Journals |
| issn | 1932-6203 |
| language | English |
| publishDate | 2011-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj-art-e870ff66676d4b4b8a60ea7ffd24f2bd2025-08-20T02:30:54ZengPublic Library of Science (PLoS)PLoS ONE1932-62032011-01-0169e2420310.1371/journal.pone.0024203Functional polymorphism of the mu-opioid receptor gene (OPRM1) influences reinforcement learning in humans.Mary R LeeCourtney L GallenXiaochu ZhangColin A HodgkinsonDavid GoldmanElliot A SteinChristina S BarrPrevious reports on the functional effects (i.e., gain or loss of function), and phenotypic outcomes (e.g., changes in addiction vulnerability and stress response) of a commonly occurring functional single nucleotide polymorphism (SNP) of the mu-opioid receptor (OPRM1 A118G) have been inconsistent. Here we examine the effect of this polymorphism on implicit reward learning. We used a probabilistic signal detection task to determine whether this polymorphism impacts response bias to monetary reward in 63 healthy adult subjects: 51 AA homozygotes and 12 G allele carriers. OPRM1 AA homozygotes exhibited typical responding to the rewarded response--that is, their bias to the rewarded stimulus increased over time. However, OPRM1 G allele carriers exhibited a decline in response to the rewarded stimulus compared to the AA homozygotes. These results extend previous reports on the heritability of performance on this task by implicating a specific polymorphism. Through comparison with other studies using this task, we suggest a possible mechanism by which the OPRM1 polymorphism may confer reduced response to natural reward through a dopamine-mediated decrease during positive reinforcement learning.https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0024203&type=printable |
| spellingShingle | Mary R Lee Courtney L Gallen Xiaochu Zhang Colin A Hodgkinson David Goldman Elliot A Stein Christina S Barr Functional polymorphism of the mu-opioid receptor gene (OPRM1) influences reinforcement learning in humans. PLoS ONE |
| title | Functional polymorphism of the mu-opioid receptor gene (OPRM1) influences reinforcement learning in humans. |
| title_full | Functional polymorphism of the mu-opioid receptor gene (OPRM1) influences reinforcement learning in humans. |
| title_fullStr | Functional polymorphism of the mu-opioid receptor gene (OPRM1) influences reinforcement learning in humans. |
| title_full_unstemmed | Functional polymorphism of the mu-opioid receptor gene (OPRM1) influences reinforcement learning in humans. |
| title_short | Functional polymorphism of the mu-opioid receptor gene (OPRM1) influences reinforcement learning in humans. |
| title_sort | functional polymorphism of the mu opioid receptor gene oprm1 influences reinforcement learning in humans |
| url | https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0024203&type=printable |
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