Association between the triglyceride glucose index and short-term mortality in septic patients with or without obesity: a retrospective cohort study
Background Sepsis is a significant contributor to both intensive care unit (ICU) admissions and mortality among patients in ICU, with a rising prevalence of obesity. There is a lack of extensive research on the correlation between TyGI and findings in patients with sepsis, especially in obese patien...
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Taylor & Francis Group
2024-12-01
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| Series: | Adipocyte |
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| Online Access: | https://www.tandfonline.com/doi/10.1080/21623945.2024.2379867 |
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| author | Zhou Lv Juntao Wang Minglu Gu Liuyan Zhou Saie Shen Chunmei Huang |
| author_facet | Zhou Lv Juntao Wang Minglu Gu Liuyan Zhou Saie Shen Chunmei Huang |
| author_sort | Zhou Lv |
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| description | Background Sepsis is a significant contributor to both intensive care unit (ICU) admissions and mortality among patients in ICU, with a rising prevalence of obesity. There is a lack of extensive research on the correlation between TyGI and findings in patients with sepsis, especially in obese patients.Methods This study used a retrospective cohort design and included patients with sepsis (≥18 years) from the Medical Information Mart for Intensive Care IV database. The association between TyGI and outcome was examined using multivariable logistic regression analysis.Results 8,840 patients with sepsis were included in the analysis. The in-ICU mortality rate was 9.7%. Non-survivors exhibited significantly greater TyGI levels than survivors [9.19(8.76–9.71) vs. 9.10(8.67–9.54), p < 0.001]. The adjusted multivariate regression model showed that elevated TyGI values were linked to a greater likelihood of death in ICU (odds ratio [OR] range 1.072–1.793, p < 0.001) and hospital (OR range 1.068–1.445, p = 0.005). Restricted Cubic Spline analysis revealed a nonlinear association between TyGI and in-ICU and in-hospital mortality risks within specified ranges. Subgroup analysis revealed interaction effects in the general obesity, abdominal obesity, and impaired fasting glucose subgroups (p = 0.014, 0.016, and < 0.001, respectively).Conclusion TyGI was associated with an increased sepsis-related short-term mortality risk and adverse outcomes after ICU admission. |
| format | Article |
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| institution | OA Journals |
| issn | 2162-3945 2162-397X |
| language | English |
| publishDate | 2024-12-01 |
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| spelling | doaj-art-e870981028134fd385967052357861d32025-08-20T02:30:42ZengTaylor & Francis GroupAdipocyte2162-39452162-397X2024-12-0113110.1080/21623945.2024.2379867Association between the triglyceride glucose index and short-term mortality in septic patients with or without obesity: a retrospective cohort studyZhou Lv0Juntao Wang1Minglu Gu2Liuyan Zhou3Saie Shen4Chunmei Huang5Department of Anesthesiology and Surgical Intensive Care Unit, Xinhua Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, ChinaDepartment of Anesthesiology, The affiliated Hospital of Qingdao University, Qingdao, ChinaDepartment of Anesthesiology and Surgical Intensive Care Unit, Xinhua Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, ChinaDepartment of Anesthesiology and Surgical Intensive Care Unit, Xinhua Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, ChinaDepartment of Anesthesiology and Surgical Intensive Care Unit, Xinhua Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, ChinaDepartment of Geriatrics, Xinhua Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, ChinaBackground Sepsis is a significant contributor to both intensive care unit (ICU) admissions and mortality among patients in ICU, with a rising prevalence of obesity. There is a lack of extensive research on the correlation between TyGI and findings in patients with sepsis, especially in obese patients.Methods This study used a retrospective cohort design and included patients with sepsis (≥18 years) from the Medical Information Mart for Intensive Care IV database. The association between TyGI and outcome was examined using multivariable logistic regression analysis.Results 8,840 patients with sepsis were included in the analysis. The in-ICU mortality rate was 9.7%. Non-survivors exhibited significantly greater TyGI levels than survivors [9.19(8.76–9.71) vs. 9.10(8.67–9.54), p < 0.001]. The adjusted multivariate regression model showed that elevated TyGI values were linked to a greater likelihood of death in ICU (odds ratio [OR] range 1.072–1.793, p < 0.001) and hospital (OR range 1.068–1.445, p = 0.005). Restricted Cubic Spline analysis revealed a nonlinear association between TyGI and in-ICU and in-hospital mortality risks within specified ranges. Subgroup analysis revealed interaction effects in the general obesity, abdominal obesity, and impaired fasting glucose subgroups (p = 0.014, 0.016, and < 0.001, respectively).Conclusion TyGI was associated with an increased sepsis-related short-term mortality risk and adverse outcomes after ICU admission.https://www.tandfonline.com/doi/10.1080/21623945.2024.2379867Triglyceride-glucose indexsepsisshort-term mortalitymetabolic syndromeobesity paradox |
| spellingShingle | Zhou Lv Juntao Wang Minglu Gu Liuyan Zhou Saie Shen Chunmei Huang Association between the triglyceride glucose index and short-term mortality in septic patients with or without obesity: a retrospective cohort study Adipocyte Triglyceride-glucose index sepsis short-term mortality metabolic syndrome obesity paradox |
| title | Association between the triglyceride glucose index and short-term mortality in septic patients with or without obesity: a retrospective cohort study |
| title_full | Association between the triglyceride glucose index and short-term mortality in septic patients with or without obesity: a retrospective cohort study |
| title_fullStr | Association between the triglyceride glucose index and short-term mortality in septic patients with or without obesity: a retrospective cohort study |
| title_full_unstemmed | Association between the triglyceride glucose index and short-term mortality in septic patients with or without obesity: a retrospective cohort study |
| title_short | Association between the triglyceride glucose index and short-term mortality in septic patients with or without obesity: a retrospective cohort study |
| title_sort | association between the triglyceride glucose index and short term mortality in septic patients with or without obesity a retrospective cohort study |
| topic | Triglyceride-glucose index sepsis short-term mortality metabolic syndrome obesity paradox |
| url | https://www.tandfonline.com/doi/10.1080/21623945.2024.2379867 |
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