Is there a link between heart rate variability and cognitive decline? A cross-sectional study on patients with mild cognitive impairment and cognitively healthy controls
Background Given that, up to date, there is no effective strategy to treat dementia, a timely start of interventions in a prodromal stage such as mild cognitive impairment (MCI) is considered an important option to lower the overall societal burden. Although autonomic functions have been related to...
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| Format: | Article |
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Thieme Revinter Publicações
2023-01-01
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| Series: | Arquivos de Neuro-Psiquiatria |
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| Online Access: | http://www.thieme-connect.de/DOI/DOI?10.1055/s-0042-1758862 |
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| author | Bernhard Grässler Milos Dordevic Sabine Darius Fabian Herold Giuseppe Forte Corinna Langhans Nicole Halfpaap Patrick Müller Wenzel Glanz Estélio Henrique Martin Dantas Irina Böckelmann Notger Müller Anita Hökelmann |
| author_facet | Bernhard Grässler Milos Dordevic Sabine Darius Fabian Herold Giuseppe Forte Corinna Langhans Nicole Halfpaap Patrick Müller Wenzel Glanz Estélio Henrique Martin Dantas Irina Böckelmann Notger Müller Anita Hökelmann |
| author_sort | Bernhard Grässler |
| collection | DOAJ |
| description | Background Given that, up to date, there is no effective strategy to treat dementia, a timely start of interventions in a prodromal stage such as mild cognitive impairment (MCI) is considered an important option to lower the overall societal burden. Although autonomic functions have been related to cognitive performance, both aspects have rarely been studied simultaneously in MCI.
Objective The aim of the present study was to investigate cardiac autonomic control in older adults with and without MCI.
Methods Cardiac autonomic control was assessed by means of heart rate variability (HRV) at resting state and during cognitive tasks in 22 older adults with MCI and 29 healthy controls (HCs). Resting HRV measurement was performed for 5 minutes during a sitting position. Afterwards, participants performed three PC-based tasks to probe performance in executive functions and language abilities (i.e., Stroop, N-back, and a verbal fluency task).
Results Participants with MCI showed a significant reduction of HRV in the frequency-domain (high frequency power) and nonlinear indices (SD2, D2, and DFA1) during resting state compared to HCs. Older individuals with MCI exhibited decreases in RMSSD and increases in DFA1 from resting state to Stroop and N-back tasks, reflecting strong vagal withdrawal, while this parameter remained stable in HCs.
Conclusion The results support the presence of autonomic dysfunction at the early stage of cognitive impairment. Heart rate variability could help in the prediction of cognitive decline as a noninvasive biomarker or as a tool to monitor the effectiveness of therapy and prevention of neurodegenerative diseases. |
| format | Article |
| id | doaj-art-e8705551cbec44f9a6046af2f80d54ce |
| institution | Kabale University |
| issn | 0004-282X 1678-4227 |
| language | English |
| publishDate | 2023-01-01 |
| publisher | Thieme Revinter Publicações |
| record_format | Article |
| series | Arquivos de Neuro-Psiquiatria |
| spelling | doaj-art-e8705551cbec44f9a6046af2f80d54ce2025-08-20T03:24:47ZengThieme Revinter PublicaçõesArquivos de Neuro-Psiquiatria0004-282X1678-42272023-01-01810100901810.1055/s-0042-1758862Is there a link between heart rate variability and cognitive decline? A cross-sectional study on patients with mild cognitive impairment and cognitively healthy controlsBernhard Grässler0Milos Dordevic1Sabine Darius2Fabian Herold3Giuseppe Forte4Corinna Langhans5Nicole Halfpaap6Patrick Müller7Wenzel Glanz8Estélio Henrique Martin Dantas9Irina Böckelmann10Notger Müller11Anita Hökelmann12Otto von Guericke University, Institute of Sport Science, Magdeburg, Germany.German Center for Neurodegenerative Diseases, Neuroprotection Research Group, Magdeburg, Germany.Otto von Guericke University, Faculty of Medicine, Department of Occupational Medicine, Magdeburg, Germany.German Center for Neurodegenerative Diseases, Neuroprotection Research Group, Magdeburg, Germany.Sapienza Università di Roma, Dipartimento di Psicologia, Rome, Italy.Otto von Guericke University, Institute of Sport Science, Magdeburg, Germany.Otto von Guericke University, Institute of Sport Science, Magdeburg, Germany.German Center for Neurodegenerative Diseases, Neuroprotection Research Group, Magdeburg, Germany.German Research Group Neuroprotection Center for Neurodegenerative Diseases, Magdeburg, Germany.Universidade Federal do Estado do Rio de Janeiro, Programa de Pós- Graduação em Enfermagem e Biociências, Rio de Janeiro RJ, Brazil.Otto von Guericke University, Faculty of Medicine, Department of Occupational Medicine, Magdeburg, Germany.German Center for Neurodegenerative Diseases, Neuroprotection Research Group, Magdeburg, Germany.Otto von Guericke University, Institute of Sport Science, Magdeburg, Germany.Background Given that, up to date, there is no effective strategy to treat dementia, a timely start of interventions in a prodromal stage such as mild cognitive impairment (MCI) is considered an important option to lower the overall societal burden. Although autonomic functions have been related to cognitive performance, both aspects have rarely been studied simultaneously in MCI. Objective The aim of the present study was to investigate cardiac autonomic control in older adults with and without MCI. Methods Cardiac autonomic control was assessed by means of heart rate variability (HRV) at resting state and during cognitive tasks in 22 older adults with MCI and 29 healthy controls (HCs). Resting HRV measurement was performed for 5 minutes during a sitting position. Afterwards, participants performed three PC-based tasks to probe performance in executive functions and language abilities (i.e., Stroop, N-back, and a verbal fluency task). Results Participants with MCI showed a significant reduction of HRV in the frequency-domain (high frequency power) and nonlinear indices (SD2, D2, and DFA1) during resting state compared to HCs. Older individuals with MCI exhibited decreases in RMSSD and increases in DFA1 from resting state to Stroop and N-back tasks, reflecting strong vagal withdrawal, while this parameter remained stable in HCs. Conclusion The results support the presence of autonomic dysfunction at the early stage of cognitive impairment. Heart rate variability could help in the prediction of cognitive decline as a noninvasive biomarker or as a tool to monitor the effectiveness of therapy and prevention of neurodegenerative diseases.http://www.thieme-connect.de/DOI/DOI?10.1055/s-0042-1758862heart ratecognitive dysfunctioncognitionautonomic nervous system diseases |
| spellingShingle | Bernhard Grässler Milos Dordevic Sabine Darius Fabian Herold Giuseppe Forte Corinna Langhans Nicole Halfpaap Patrick Müller Wenzel Glanz Estélio Henrique Martin Dantas Irina Böckelmann Notger Müller Anita Hökelmann Is there a link between heart rate variability and cognitive decline? A cross-sectional study on patients with mild cognitive impairment and cognitively healthy controls Arquivos de Neuro-Psiquiatria heart rate cognitive dysfunction cognition autonomic nervous system diseases |
| title | Is there a link between heart rate variability and cognitive decline? A cross-sectional study on patients with mild cognitive impairment and cognitively healthy controls |
| title_full | Is there a link between heart rate variability and cognitive decline? A cross-sectional study on patients with mild cognitive impairment and cognitively healthy controls |
| title_fullStr | Is there a link between heart rate variability and cognitive decline? A cross-sectional study on patients with mild cognitive impairment and cognitively healthy controls |
| title_full_unstemmed | Is there a link between heart rate variability and cognitive decline? A cross-sectional study on patients with mild cognitive impairment and cognitively healthy controls |
| title_short | Is there a link between heart rate variability and cognitive decline? A cross-sectional study on patients with mild cognitive impairment and cognitively healthy controls |
| title_sort | is there a link between heart rate variability and cognitive decline a cross sectional study on patients with mild cognitive impairment and cognitively healthy controls |
| topic | heart rate cognitive dysfunction cognition autonomic nervous system diseases |
| url | http://www.thieme-connect.de/DOI/DOI?10.1055/s-0042-1758862 |
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