Loss of Cullin 5 in myeloid cells protects against autoimmune neuroinflammation

Loss of Cullin 5 in myeloid cells protects against autoimmune neuroinflammation

Autoimmune neuroinflammation occurs when an individual’s immune cells attack the brain, spinal cord or peripheral nerves. Several Suppressor of Cytokine Signaling (SOCS) proteins have been shown to limit pro-inflammatory signaling pathways in myeloid cells and prevent neuroinflammation. They rely on...

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Bibliographic Details
Main Authors: Yohaniz Ortega-Burgos, Asif A. Dar, Siera A. Tomishima, Ipsita Guha, Carleigh O’ Brien, Nadia Porter, F. Chris Bennett, Paula M. Oliver
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-08-01
Series:Frontiers in Immunology
Subjects:
Cullin 5
neuroinflammation
macrophages
ubiquitin ligase (E3)
macrophage polarization
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2025.1611818/full
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