A chemotherapy nano-booster unlocks wider therapeutic window for prostate cancer treatment
Clinical chemotherapy for prostate cancer is still compromised by high treatment thresholds and severe off-target toxicity of drugs. Given the limited progress in improving therapeutic outcomes and reducing toxicity with the existing toolbox, efforts to broaden the chemotherapeutic window are highly...
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| Format: | Article |
| Language: | English |
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Elsevier
2025-06-01
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| Series: | Acta Pharmaceutica Sinica B |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2211383525001662 |
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| author | Rui Liao Yuequan Wang Ziqi Lin Yuting Wang Hongyuan Zhang Qin Chen Shenwu Zhang Jin Sun Zhonggui He Cong Luo |
| author_facet | Rui Liao Yuequan Wang Ziqi Lin Yuting Wang Hongyuan Zhang Qin Chen Shenwu Zhang Jin Sun Zhonggui He Cong Luo |
| author_sort | Rui Liao |
| collection | DOAJ |
| description | Clinical chemotherapy for prostate cancer is still compromised by high treatment thresholds and severe off-target toxicity of drugs. Given the limited progress in improving therapeutic outcomes and reducing toxicity with the existing toolbox, efforts to broaden the chemotherapeutic window are highly desired. Here, we discover that gossypol (GSP, a natural compound) dramatically enhances the chemosensitivity of cabazitaxel (CTX), even at previously ineffective concentrations. Based on this interesting finding, we exploit a carrier-free chemotherapeutic nano-booster for prostate cancer treatment, which is molecularly co-assembled by GSP and cabazitaxel (CTX). GSP not only readily forms nanoassembly with CTX, but also functions as a chemotherapeutic enhancer that unlocks an ultra-low-dose chemotherapeutic window. Not only that, precise dual-drug nanoassembly confers CTX a significantly larger maximum tolerable dose. As expected, the nano-booster exerts striking therapeutic benefits in mouse prostate tumor xenograft models. This study advances chemotherapeutic window expansion and self-sensitized chemotherapy toward clinical applicability. |
| format | Article |
| id | doaj-art-e86d799b946149dba9414f32b597a928 |
| institution | Kabale University |
| issn | 2211-3835 |
| language | English |
| publishDate | 2025-06-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Acta Pharmaceutica Sinica B |
| spelling | doaj-art-e86d799b946149dba9414f32b597a9282025-08-20T03:27:02ZengElsevierActa Pharmaceutica Sinica B2211-38352025-06-011563273329010.1016/j.apsb.2025.03.029A chemotherapy nano-booster unlocks wider therapeutic window for prostate cancer treatmentRui Liao0Yuequan Wang1Ziqi Lin2Yuting Wang3Hongyuan Zhang4Qin Chen5Shenwu Zhang6Jin Sun7Zhonggui He8Cong Luo9Department of Pharmaceutics, Wuya College of Innovation, Shenyang Pharmaceutical University, Shenyang, 110016, ChinaDepartment of Pharmaceutics, Wuya College of Innovation, Shenyang Pharmaceutical University, Shenyang, 110016, ChinaDepartment of Pharmaceutics, Wuya College of Innovation, Shenyang Pharmaceutical University, Shenyang, 110016, ChinaDepartment of Pharmaceutics, Wuya College of Innovation, Shenyang Pharmaceutical University, Shenyang, 110016, ChinaDepartment of Pharmaceutics, Wuya College of Innovation, Shenyang Pharmaceutical University, Shenyang, 110016, ChinaDepartment of Pharmacy, Cancer Hospital of China Medical University, Liaoning Cancer Hospital & Institute, Shenyang, 110042, ChinaDepartment of Pharmaceutics, Wuya College of Innovation, Shenyang Pharmaceutical University, Shenyang, 110016, China; Joint International Research Laboratory of Intelligent Drug Delivery Systems, Ministry of Education, Shenyang Pharmaceutical University, Shenyang, 110016, ChinaDepartment of Pharmaceutics, Wuya College of Innovation, Shenyang Pharmaceutical University, Shenyang, 110016, China; Joint International Research Laboratory of Intelligent Drug Delivery Systems, Ministry of Education, Shenyang Pharmaceutical University, Shenyang, 110016, ChinaDepartment of Pharmaceutics, Wuya College of Innovation, Shenyang Pharmaceutical University, Shenyang, 110016, China; Joint International Research Laboratory of Intelligent Drug Delivery Systems, Ministry of Education, Shenyang Pharmaceutical University, Shenyang, 110016, ChinaDepartment of Pharmaceutics, Wuya College of Innovation, Shenyang Pharmaceutical University, Shenyang, 110016, China; Joint International Research Laboratory of Intelligent Drug Delivery Systems, Ministry of Education, Shenyang Pharmaceutical University, Shenyang, 110016, China; Corresponding author.Clinical chemotherapy for prostate cancer is still compromised by high treatment thresholds and severe off-target toxicity of drugs. Given the limited progress in improving therapeutic outcomes and reducing toxicity with the existing toolbox, efforts to broaden the chemotherapeutic window are highly desired. Here, we discover that gossypol (GSP, a natural compound) dramatically enhances the chemosensitivity of cabazitaxel (CTX), even at previously ineffective concentrations. Based on this interesting finding, we exploit a carrier-free chemotherapeutic nano-booster for prostate cancer treatment, which is molecularly co-assembled by GSP and cabazitaxel (CTX). GSP not only readily forms nanoassembly with CTX, but also functions as a chemotherapeutic enhancer that unlocks an ultra-low-dose chemotherapeutic window. Not only that, precise dual-drug nanoassembly confers CTX a significantly larger maximum tolerable dose. As expected, the nano-booster exerts striking therapeutic benefits in mouse prostate tumor xenograft models. This study advances chemotherapeutic window expansion and self-sensitized chemotherapy toward clinical applicability.http://www.sciencedirect.com/science/article/pii/S2211383525001662Prostate cancer treatmentGossypolCabazitaxelChemotherapeutic enhancerPrecise dual-drug nanoassemblyTherapeutic window broadening |
| spellingShingle | Rui Liao Yuequan Wang Ziqi Lin Yuting Wang Hongyuan Zhang Qin Chen Shenwu Zhang Jin Sun Zhonggui He Cong Luo A chemotherapy nano-booster unlocks wider therapeutic window for prostate cancer treatment Acta Pharmaceutica Sinica B Prostate cancer treatment Gossypol Cabazitaxel Chemotherapeutic enhancer Precise dual-drug nanoassembly Therapeutic window broadening |
| title | A chemotherapy nano-booster unlocks wider therapeutic window for prostate cancer treatment |
| title_full | A chemotherapy nano-booster unlocks wider therapeutic window for prostate cancer treatment |
| title_fullStr | A chemotherapy nano-booster unlocks wider therapeutic window for prostate cancer treatment |
| title_full_unstemmed | A chemotherapy nano-booster unlocks wider therapeutic window for prostate cancer treatment |
| title_short | A chemotherapy nano-booster unlocks wider therapeutic window for prostate cancer treatment |
| title_sort | chemotherapy nano booster unlocks wider therapeutic window for prostate cancer treatment |
| topic | Prostate cancer treatment Gossypol Cabazitaxel Chemotherapeutic enhancer Precise dual-drug nanoassembly Therapeutic window broadening |
| url | http://www.sciencedirect.com/science/article/pii/S2211383525001662 |
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