Characterization of neutralizing versus binding antibody and T cell responses to varicella-zoster virus in the elderly

Characterization of neutralizing versus binding antibody and T cell responses to varicella-zoster virus in the elderly

Abstract Age-related immune changes increase the risk of herpes zoster (HZ) caused by varicella-zoster virus (VZV) reactivation. Understanding immune responses to VZV is crucial for reducing the burden of HZ in aging populations. Due to the limited availability of data regarding the VZV immune profi...

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Main Authors: Suthee Mangmee, Supasek Kardkarnklai, Suphanun Phuphanitcharoenkun, Sarocha Suthisawat, Oranit Li-Khit, Nattaya Kamchompoo, Rae Apaivongse Coad, Patimaporn Wongprompitak, Jarupa Soongsathitanon, Tararaj Dharakul, Kamol Suwannakarn, Chutikarn Chaimayo, Weerasak Muangpaisan, Somboon Intalapaporn, Prasert Assantachai, Kobporn Boonnak
Format: Article
Language:English
Published: Nature Portfolio 2025-04-01
Series:Scientific Reports
Subjects:
Varicella-zoster virus
Shingles
Immunosenescence
Aging
Online Access:https://doi.org/10.1038/s41598-025-98107-8
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