Engineered circular RNA-based DLL3-targeted CAR-T therapy for small cell lung cancer

Engineered circular RNA-based DLL3-targeted CAR-T therapy for small cell lung cancer

Abstract Purpose Circular RNA (circRNA) has emerged as a promising RNA therapeutic molecule due to its enhanced stability and prolonged protein expression compared to messenger RNA (mRNA). Using circRNA to construct transient Chimeric Antigen Receptor (CAR)-T cells can mitigate the limitations of co...

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Main Authors: Jingsheng Cai, Zheng Liu, Shaoyi Chen, Jingwei Zhang, Haoran Li, Xun Wang, Feng Yang, Shaodong Wang, Xiao Li, Yun Li, Kezhong Chen, Jun Wang, Ming Sun, Mantang Qiu
Format: Article
Language:English
Published: BMC 2025-03-01
Series:Experimental Hematology & Oncology
Subjects:
Circular RNA
Electroporation
CAR-T
Delta-like Ligand 3
Small cell lung cancer
Online Access:https://doi.org/10.1186/s40164-025-00625-8
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