TRANSCENDENT (Transforming Research by Assessing Neuroinformatics across the Spectrum of Concussion by Embedding iNterdisciplinary Data-collection to Enable Novel Treatments): protocol for a prospective observational cohort study of concussion patients with embedded comparative effectiveness research within a network of learning health system concussion clinics in Canada
Introduction Concussion affects over 400 000 Canadians annually, with a range of causes and impacts on health-related quality of life. Research to date has disproportionately focused on athletes, military personnel and level I trauma centre patients, and may not be applicable to the broader communit...
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BMJ Publishing Group
2025-04-01
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| Series: | BMJ Open |
| Online Access: | https://bmjopen.bmj.com/content/15/4/e095292.full |
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| author | Charlotte Anderson Nick Reed Andrée-Anne Ledoux Roger Zemek Keith Yeates Carolyn Emery Pamela Fuselli Isabelle J Gagnon Kathryn J Schneider Sharon Johnston David R Howell Richard Webster Peter Tanuseputro Andrew R Mayer Miriam H Beauchamp Rebecca Robillard Christina L Master Kristine Dalton Khaled El Emam John Leddy Noah Silverberg Jennifer Dawson Martin H Osmond Stephanie Cowle Christopher Giza Monica Lamoureux Nicholas Barrowman Kitty Chen Daniel J Corwin Erin Fox Lisa M Albrecht Araba Chintoh Achelle Cortel-LeBlanc Miguel Cortel-LeBlanc Andrew Dodd Steven Hicks Stephen Alexander Kutcher Carlos Lalonde Rebekah C Mannix Ivan Terekhov Cheryl Lea Wellington |
| author_facet | Charlotte Anderson Nick Reed Andrée-Anne Ledoux Roger Zemek Keith Yeates Carolyn Emery Pamela Fuselli Isabelle J Gagnon Kathryn J Schneider Sharon Johnston David R Howell Richard Webster Peter Tanuseputro Andrew R Mayer Miriam H Beauchamp Rebecca Robillard Christina L Master Kristine Dalton Khaled El Emam John Leddy Noah Silverberg Jennifer Dawson Martin H Osmond Stephanie Cowle Christopher Giza Monica Lamoureux Nicholas Barrowman Kitty Chen Daniel J Corwin Erin Fox Lisa M Albrecht Araba Chintoh Achelle Cortel-LeBlanc Miguel Cortel-LeBlanc Andrew Dodd Steven Hicks Stephen Alexander Kutcher Carlos Lalonde Rebekah C Mannix Ivan Terekhov Cheryl Lea Wellington |
| author_sort | Charlotte Anderson |
| collection | DOAJ |
| description | Introduction Concussion affects over 400 000 Canadians annually, with a range of causes and impacts on health-related quality of life. Research to date has disproportionately focused on athletes, military personnel and level I trauma centre patients, and may not be applicable to the broader community. The TRANSCENDENT Concussion Research Program aims to address patient- and clinician-identified research priorities, through the integration of clinical data from patients of all ages and injury mechanisms, patient-reported outcomes and objective biomarkers across factors of intersectionality. Seeking guidance from our Community Advisory Committee will ensure meaningful patient partnership and research findings that are relevant to the wider concussion community.Methods and analysis This prospective observational cohort study will recruit 5500 participants over 5 years from three 360 Concussion Care clinic locations across Ontario, Canada, with a subset of participants enrolling in specific objective assessments including testing of autonomic function, exercise tolerance, vision, advanced neuroimaging and fluid biomarkers. Analysis will be predicated on pre-specified research questions, and data shared with the Ontario Brain Institute’s Brain-CODE database. This work will represent one of the largest concussion databases to date, and by sharing it, we will advance the field of concussion and prevent siloing within brain health research.Ethics and dissemination This study was approved by the Children’s Hospital of Eastern Ontario Research Ethics Board and preregistered on OSF (25 June 2024); https://doi.org/10.17605/OSF.IO/HYDZC. Dissemination of findings will be multifaceted, including conference presentations, peer-reviewed publications and sharing of adapted materials (eg, videos, infographics, plain language summaries) with community groups and key knowledge users. |
| format | Article |
| id | doaj-art-e85ed933d4ca4bb7b713ae2a81580b99 |
| institution | OA Journals |
| issn | 2044-6055 |
| language | English |
| publishDate | 2025-04-01 |
| publisher | BMJ Publishing Group |
| record_format | Article |
| series | BMJ Open |
| spelling | doaj-art-e85ed933d4ca4bb7b713ae2a81580b992025-08-20T01:47:33ZengBMJ Publishing GroupBMJ Open2044-60552025-04-0115410.1136/bmjopen-2024-095292TRANSCENDENT (Transforming Research by Assessing Neuroinformatics across the Spectrum of Concussion by Embedding iNterdisciplinary Data-collection to Enable Novel Treatments): protocol for a prospective observational cohort study of concussion patients with embedded comparative effectiveness research within a network of learning health system concussion clinics in CanadaCharlotte Anderson0Nick Reed1Andrée-Anne Ledoux2Roger Zemek3Keith Yeates4Carolyn Emery5Pamela Fuselli6Isabelle J Gagnon7Kathryn J Schneider8Sharon Johnston9David R Howell10Richard Webster11Peter Tanuseputro12Andrew R Mayer13Miriam H Beauchamp14Rebecca Robillard15Christina L Master16Kristine Dalton17Khaled El Emam18John Leddy19Noah Silverberg20Jennifer Dawson21Martin H Osmond22Stephanie Cowle23Christopher Giza24Monica Lamoureux25Nicholas Barrowman26Kitty Chen27Daniel J Corwin28Erin Fox29Lisa M Albrecht30Araba Chintoh31Achelle Cortel-LeBlanc32Miguel Cortel-LeBlanc33Andrew Dodd34Steven Hicks35Stephen Alexander Kutcher36Carlos Lalonde37Rebekah C Mannix38Ivan Terekhov39Cheryl Lea Wellington40UK Health Security Agency, London, UK12 Department of Occupational Science and Occupational Therapy, University of Toronto, Toronto, Ontario, Canada1 Children`s Hospital of Eastern Ontario Research Institute, Ottawa, Ontario, Canada37 Pediatrics, Children`s Hospital of Eastern Ontario, Ottawa, Ontario, Canada4 Department of Psychology, University of Calgary, Calgary, Alberta, CanadaSport Injury Prevention Research Centre, Faculty of Kinesiology and Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada2Parachute, Toronto, ON, CanadaDivision of Pediatric Emergency Medicine, McGill University Health Centre, Montreal Children’s Hospital, Montreal, Quebec, CanadaSport Injury Prevention Research Centre, Faculty of Kinesiology, University of Calgary, Calgary, Alberta, CanadaUniversity of Ottawa Department of Family Medicine, Ottawa, Ontario, CanadaDepartment of Orthopedics, University of Colorado Anschutz, Aurora, Colorado, USA1 Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford, Oxfordshire, UK2 Department of Palliative Care, Bruyère Health Research Institute, Ottawa, Ontario, Canada3 Neurology and Psychiatry, University of New Mexico School of Medicine, Albuquerque, New Mexico, USACentre de recherche, CHU Sainte-Justine, Montréal, Québec, CanadaSchool of Psychology, University of Ottawa, Ottawa, Ontario, CanadaDepartment of Pediatrics and Orthopaedic Surgery, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania, USASchool of Optometry & Vision Science, University of Waterloo, Waterloo, Ontario, Canada9 Electronic Health Information Laboratory, Children’s Hospital of Eastern Ontario Research Institute, Ottawa, Ontario, Canada9 University at Buffalo Concussion Management Clinic, UBMD Orthopaedics and Sports Medicine, Buffalo, New York, USA1 Department of Psychology, The University of British Columbia, Vancouver, British Columbia, Canada3University of Ottawa, Ottawa, CanadaDepartments of Pediatrics and Emergency Medicine, University of Ottawa, Ottawa, Ontario, Canada2Parachute, Toronto, ON, CanadaPediatrics and Neurosurgery, University of California, Los Angeles, California, USAChildren`s Hospital of Eastern Ontario, Ottawa, Ontario, Canada3 CHEO Research Institute, Ottawa, Ontario, Canada1 Dalla Lana School of Public Health, University of Toronto, Toronto, Ontario, CanadaDivision of Emergency Medicine, Children`s Hospital of Philadelphia, Philadelphia, PA, USADepartment of Surgery, University of Texas Health Science Center, Houston, Texas, USAChildren’s Hospital of Eastern Ontario Research Institute, Ottawa, Ontario, CanadaPsychiatry, University of Calgary, Calgary, Alberta, CanadaFaculty of Medicine, University of Ottawa, Ottawa, Ontario, CanadaFaculty of Medicine, University of Ottawa, Ottawa, Ontario, CanadaChildren’s Hospital of Eastern Ontario Research Institute, Ottawa, Ontario, CanadaPenn State College of Medicine, Hershey, Pennsylvania, USAChildren’s Hospital of Eastern Ontario Research Institute, Ottawa, Ontario, CanadaHomewood Health, Guelph, Ontario, CanadaPediatrics, Boston Children’s Hospital, Boston, Massachusetts, USAChildren’s Hospital of Eastern Ontario Research Institute, Ottawa, Ontario, CanadaFaculty of Medicine, The University of British Columbia, Vancouver, British Columbia, CanadaIntroduction Concussion affects over 400 000 Canadians annually, with a range of causes and impacts on health-related quality of life. Research to date has disproportionately focused on athletes, military personnel and level I trauma centre patients, and may not be applicable to the broader community. The TRANSCENDENT Concussion Research Program aims to address patient- and clinician-identified research priorities, through the integration of clinical data from patients of all ages and injury mechanisms, patient-reported outcomes and objective biomarkers across factors of intersectionality. Seeking guidance from our Community Advisory Committee will ensure meaningful patient partnership and research findings that are relevant to the wider concussion community.Methods and analysis This prospective observational cohort study will recruit 5500 participants over 5 years from three 360 Concussion Care clinic locations across Ontario, Canada, with a subset of participants enrolling in specific objective assessments including testing of autonomic function, exercise tolerance, vision, advanced neuroimaging and fluid biomarkers. Analysis will be predicated on pre-specified research questions, and data shared with the Ontario Brain Institute’s Brain-CODE database. This work will represent one of the largest concussion databases to date, and by sharing it, we will advance the field of concussion and prevent siloing within brain health research.Ethics and dissemination This study was approved by the Children’s Hospital of Eastern Ontario Research Ethics Board and preregistered on OSF (25 June 2024); https://doi.org/10.17605/OSF.IO/HYDZC. Dissemination of findings will be multifaceted, including conference presentations, peer-reviewed publications and sharing of adapted materials (eg, videos, infographics, plain language summaries) with community groups and key knowledge users.https://bmjopen.bmj.com/content/15/4/e095292.full |
| spellingShingle | Charlotte Anderson Nick Reed Andrée-Anne Ledoux Roger Zemek Keith Yeates Carolyn Emery Pamela Fuselli Isabelle J Gagnon Kathryn J Schneider Sharon Johnston David R Howell Richard Webster Peter Tanuseputro Andrew R Mayer Miriam H Beauchamp Rebecca Robillard Christina L Master Kristine Dalton Khaled El Emam John Leddy Noah Silverberg Jennifer Dawson Martin H Osmond Stephanie Cowle Christopher Giza Monica Lamoureux Nicholas Barrowman Kitty Chen Daniel J Corwin Erin Fox Lisa M Albrecht Araba Chintoh Achelle Cortel-LeBlanc Miguel Cortel-LeBlanc Andrew Dodd Steven Hicks Stephen Alexander Kutcher Carlos Lalonde Rebekah C Mannix Ivan Terekhov Cheryl Lea Wellington TRANSCENDENT (Transforming Research by Assessing Neuroinformatics across the Spectrum of Concussion by Embedding iNterdisciplinary Data-collection to Enable Novel Treatments): protocol for a prospective observational cohort study of concussion patients with embedded comparative effectiveness research within a network of learning health system concussion clinics in Canada BMJ Open |
| title | TRANSCENDENT (Transforming Research by Assessing Neuroinformatics across the Spectrum of Concussion by Embedding iNterdisciplinary Data-collection to Enable Novel Treatments): protocol for a prospective observational cohort study of concussion patients with embedded comparative effectiveness research within a network of learning health system concussion clinics in Canada |
| title_full | TRANSCENDENT (Transforming Research by Assessing Neuroinformatics across the Spectrum of Concussion by Embedding iNterdisciplinary Data-collection to Enable Novel Treatments): protocol for a prospective observational cohort study of concussion patients with embedded comparative effectiveness research within a network of learning health system concussion clinics in Canada |
| title_fullStr | TRANSCENDENT (Transforming Research by Assessing Neuroinformatics across the Spectrum of Concussion by Embedding iNterdisciplinary Data-collection to Enable Novel Treatments): protocol for a prospective observational cohort study of concussion patients with embedded comparative effectiveness research within a network of learning health system concussion clinics in Canada |
| title_full_unstemmed | TRANSCENDENT (Transforming Research by Assessing Neuroinformatics across the Spectrum of Concussion by Embedding iNterdisciplinary Data-collection to Enable Novel Treatments): protocol for a prospective observational cohort study of concussion patients with embedded comparative effectiveness research within a network of learning health system concussion clinics in Canada |
| title_short | TRANSCENDENT (Transforming Research by Assessing Neuroinformatics across the Spectrum of Concussion by Embedding iNterdisciplinary Data-collection to Enable Novel Treatments): protocol for a prospective observational cohort study of concussion patients with embedded comparative effectiveness research within a network of learning health system concussion clinics in Canada |
| title_sort | transcendent transforming research by assessing neuroinformatics across the spectrum of concussion by embedding interdisciplinary data collection to enable novel treatments protocol for a prospective observational cohort study of concussion patients with embedded comparative effectiveness research within a network of learning health system concussion clinics in canada |
| url | https://bmjopen.bmj.com/content/15/4/e095292.full |
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