Daily Optical Coherence Tomography Examinations after First Antivascular Endothelial Growth Factor Injections: An Interventional Case Series
Purpose. To evaluate daily spectral-domain optical coherence tomography (SD-OCT) changes in naive-treatment patients with diagnosis of exudative age-related macular degeneration (AMD) treated with intravitreous bevacizumab (1.25 mg), during a 30-day follow-up period. Methods. In prospective, interve...
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| Format: | Article |
| Language: | English |
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Wiley
2016-01-01
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| Series: | Journal of Ophthalmology |
| Online Access: | http://dx.doi.org/10.1155/2016/6971831 |
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| author | Eduardo A. Novais Emmerson Badaró Flavio E. Hirai Felipe Abdo Jorge Paula Leal Michel Eid Farah Eduardo B. Rodrigues |
| author_facet | Eduardo A. Novais Emmerson Badaró Flavio E. Hirai Felipe Abdo Jorge Paula Leal Michel Eid Farah Eduardo B. Rodrigues |
| author_sort | Eduardo A. Novais |
| collection | DOAJ |
| description | Purpose. To evaluate daily spectral-domain optical coherence tomography (SD-OCT) changes in naive-treatment patients with diagnosis of exudative age-related macular degeneration (AMD) treated with intravitreous bevacizumab (1.25 mg), during a 30-day follow-up period. Methods. In prospective, interventional study, SD-OCT was performed daily for 30 days after the first intravitreal injection. The baseline, initial-decrease, minimal, and final central retinal thicknesses (CRTs) were assessed. Results. Nine eyes of nine patients with neovascular AMD were enrolled. The mean baseline CRT was 625.3±182.5 μm, and the mean final CRT was 383.4±163.0 μm (mean difference, 206.1±167.6 μm), a difference that reached significance (P=0.006). After the first injection, the initial decrease in the CRT was seen as an average of one day after injection (mean CRT, 503.6±189.10 μm; P=0.0431). The speed of the reduction in the CRT tended to decrease by day 17. The mean CRT was 336.5±105.44 μm and the mean minimal CRT on day 30 was 320.75±96.38 μm. Conclusion. The CRT decreased early after the first injection. We observed a tendency for reductions in the speed with which the CRT decreased by day 17 after the first injection, which may affect retreatment regime. |
| format | Article |
| id | doaj-art-e85be9e7c49b4783b0425c0fc52a92a1 |
| institution | DOAJ |
| issn | 2090-004X 2090-0058 |
| language | English |
| publishDate | 2016-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Ophthalmology |
| spelling | doaj-art-e85be9e7c49b4783b0425c0fc52a92a12025-08-20T03:21:03ZengWileyJournal of Ophthalmology2090-004X2090-00582016-01-01201610.1155/2016/69718316971831Daily Optical Coherence Tomography Examinations after First Antivascular Endothelial Growth Factor Injections: An Interventional Case SeriesEduardo A. Novais0Emmerson Badaró1Flavio E. Hirai2Felipe Abdo Jorge3Paula Leal4Michel Eid Farah5Eduardo B. Rodrigues6Department of Ophthalmology, Federal University of São Paulo, 04023-062 São Paulo, SP, BrazilDepartment of Ophthalmology, Federal University of São Paulo, 04023-062 São Paulo, SP, BrazilDepartment of Ophthalmology, Federal University of São Paulo, 04023-062 São Paulo, SP, BrazilDepartment of Ophthalmology, Federal University of São Paulo, 04023-062 São Paulo, SP, BrazilDepartment of Ophthalmology, Federal University of São Paulo, 04023-062 São Paulo, SP, BrazilDepartment of Ophthalmology, Federal University of São Paulo, 04023-062 São Paulo, SP, BrazilDepartment of Ophthalmology, Federal University of São Paulo, 04023-062 São Paulo, SP, BrazilPurpose. To evaluate daily spectral-domain optical coherence tomography (SD-OCT) changes in naive-treatment patients with diagnosis of exudative age-related macular degeneration (AMD) treated with intravitreous bevacizumab (1.25 mg), during a 30-day follow-up period. Methods. In prospective, interventional study, SD-OCT was performed daily for 30 days after the first intravitreal injection. The baseline, initial-decrease, minimal, and final central retinal thicknesses (CRTs) were assessed. Results. Nine eyes of nine patients with neovascular AMD were enrolled. The mean baseline CRT was 625.3±182.5 μm, and the mean final CRT was 383.4±163.0 μm (mean difference, 206.1±167.6 μm), a difference that reached significance (P=0.006). After the first injection, the initial decrease in the CRT was seen as an average of one day after injection (mean CRT, 503.6±189.10 μm; P=0.0431). The speed of the reduction in the CRT tended to decrease by day 17. The mean CRT was 336.5±105.44 μm and the mean minimal CRT on day 30 was 320.75±96.38 μm. Conclusion. The CRT decreased early after the first injection. We observed a tendency for reductions in the speed with which the CRT decreased by day 17 after the first injection, which may affect retreatment regime.http://dx.doi.org/10.1155/2016/6971831 |
| spellingShingle | Eduardo A. Novais Emmerson Badaró Flavio E. Hirai Felipe Abdo Jorge Paula Leal Michel Eid Farah Eduardo B. Rodrigues Daily Optical Coherence Tomography Examinations after First Antivascular Endothelial Growth Factor Injections: An Interventional Case Series Journal of Ophthalmology |
| title | Daily Optical Coherence Tomography Examinations after First Antivascular Endothelial Growth Factor Injections: An Interventional Case Series |
| title_full | Daily Optical Coherence Tomography Examinations after First Antivascular Endothelial Growth Factor Injections: An Interventional Case Series |
| title_fullStr | Daily Optical Coherence Tomography Examinations after First Antivascular Endothelial Growth Factor Injections: An Interventional Case Series |
| title_full_unstemmed | Daily Optical Coherence Tomography Examinations after First Antivascular Endothelial Growth Factor Injections: An Interventional Case Series |
| title_short | Daily Optical Coherence Tomography Examinations after First Antivascular Endothelial Growth Factor Injections: An Interventional Case Series |
| title_sort | daily optical coherence tomography examinations after first antivascular endothelial growth factor injections an interventional case series |
| url | http://dx.doi.org/10.1155/2016/6971831 |
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