Synthesis, identification and application of the novel metal-organic framework Fe3O4@PAA@ZIF-8 for the drug delivery of ciprofloxacin and investigation of antibacterial activity
Today, metal-organic frameworks (MOFs) for the release of drugs have been studied extensively. In this research, we have investigated the novel magnetic framework including Fe3O4@PAA@ZIF-8 for the delivery of ciprofloxacin (CIP) antibiotic. Moreover, the antibacterial activity of Fe3O4@PAA@ZIF-8 and...
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2019-12-01
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| Series: | Artificial Cells, Nanomedicine, and Biotechnology |
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| Online Access: | https://www.tandfonline.com/doi/10.1080/21691401.2019.1617729 |
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| author | Maryam Esfahanian Mohammad Ali Ghasemzadeh Seyyed Mohammad Hossein Razavian |
| author_facet | Maryam Esfahanian Mohammad Ali Ghasemzadeh Seyyed Mohammad Hossein Razavian |
| author_sort | Maryam Esfahanian |
| collection | DOAJ |
| description | Today, metal-organic frameworks (MOFs) for the release of drugs have been studied extensively. In this research, we have investigated the novel magnetic framework including Fe3O4@PAA@ZIF-8 for the delivery of ciprofloxacin (CIP) antibiotic. Moreover, the antibacterial activity of Fe3O4@PAA@ZIF-8 and Fe3O4@PAA@ZIF-8@CIP screened against Staphylococcus aureus (S. aureus) and Escherichia coli (E. coli) bacteria. The structure of the nano carrier, as well as the encapsulation of the drug in the framework was confirmed by the Fourier-transform infrared spectroscopy (FT-IR), Ultraviolet–visible spectroscopy (UV–Vis), Energy-dispersive X-ray spectroscopy (EDX), X-ray crystallography (XRD), Scanning electron microscope (SEM) and Brunauer–Emmett–Teller (BET) analysis. The results of this study showed that 93% of the CIP was loaded on the synthesized framework. Drug release was done at pH: 7.4 and pH: 5 within 2 d, resulting about 73% release of the drug. |
| format | Article |
| id | doaj-art-e85a28b111c94da485374af5a449b0af |
| institution | Kabale University |
| issn | 2169-1401 2169-141X |
| language | English |
| publishDate | 2019-12-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Artificial Cells, Nanomedicine, and Biotechnology |
| spelling | doaj-art-e85a28b111c94da485374af5a449b0af2025-08-20T03:51:25ZengTaylor & Francis GroupArtificial Cells, Nanomedicine, and Biotechnology2169-14012169-141X2019-12-014712024203010.1080/21691401.2019.1617729Synthesis, identification and application of the novel metal-organic framework Fe3O4@PAA@ZIF-8 for the drug delivery of ciprofloxacin and investigation of antibacterial activityMaryam Esfahanian0Mohammad Ali Ghasemzadeh1Seyyed Mohammad Hossein Razavian2Department of Chemistry, Islamic Azad University, Qom, IranDepartment of Chemistry, Islamic Azad University, Qom, IranDepartment of Microbiology, Islamic Azad University, Qom, IranToday, metal-organic frameworks (MOFs) for the release of drugs have been studied extensively. In this research, we have investigated the novel magnetic framework including Fe3O4@PAA@ZIF-8 for the delivery of ciprofloxacin (CIP) antibiotic. Moreover, the antibacterial activity of Fe3O4@PAA@ZIF-8 and Fe3O4@PAA@ZIF-8@CIP screened against Staphylococcus aureus (S. aureus) and Escherichia coli (E. coli) bacteria. The structure of the nano carrier, as well as the encapsulation of the drug in the framework was confirmed by the Fourier-transform infrared spectroscopy (FT-IR), Ultraviolet–visible spectroscopy (UV–Vis), Energy-dispersive X-ray spectroscopy (EDX), X-ray crystallography (XRD), Scanning electron microscope (SEM) and Brunauer–Emmett–Teller (BET) analysis. The results of this study showed that 93% of the CIP was loaded on the synthesized framework. Drug release was done at pH: 7.4 and pH: 5 within 2 d, resulting about 73% release of the drug.https://www.tandfonline.com/doi/10.1080/21691401.2019.1617729Ciprofloxacinzeolite imidazoledrug deliveryFe3O4@PAA@ZIF-8antibacterial activityMOFs |
| spellingShingle | Maryam Esfahanian Mohammad Ali Ghasemzadeh Seyyed Mohammad Hossein Razavian Synthesis, identification and application of the novel metal-organic framework Fe3O4@PAA@ZIF-8 for the drug delivery of ciprofloxacin and investigation of antibacterial activity Artificial Cells, Nanomedicine, and Biotechnology Ciprofloxacin zeolite imidazole drug delivery Fe3O4@PAA@ZIF-8 antibacterial activity MOFs |
| title | Synthesis, identification and application of the novel metal-organic framework Fe3O4@PAA@ZIF-8 for the drug delivery of ciprofloxacin and investigation of antibacterial activity |
| title_full | Synthesis, identification and application of the novel metal-organic framework Fe3O4@PAA@ZIF-8 for the drug delivery of ciprofloxacin and investigation of antibacterial activity |
| title_fullStr | Synthesis, identification and application of the novel metal-organic framework Fe3O4@PAA@ZIF-8 for the drug delivery of ciprofloxacin and investigation of antibacterial activity |
| title_full_unstemmed | Synthesis, identification and application of the novel metal-organic framework Fe3O4@PAA@ZIF-8 for the drug delivery of ciprofloxacin and investigation of antibacterial activity |
| title_short | Synthesis, identification and application of the novel metal-organic framework Fe3O4@PAA@ZIF-8 for the drug delivery of ciprofloxacin and investigation of antibacterial activity |
| title_sort | synthesis identification and application of the novel metal organic framework fe3o4 paa zif 8 for the drug delivery of ciprofloxacin and investigation of antibacterial activity |
| topic | Ciprofloxacin zeolite imidazole drug delivery Fe3O4@PAA@ZIF-8 antibacterial activity MOFs |
| url | https://www.tandfonline.com/doi/10.1080/21691401.2019.1617729 |
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