Predictors of the efficacy of intraoperative radiotherapy in organ-preserving treatment of early breast cancer
Background. Despite the improvement in combined modality treatment of early breast cancer (BC), the rate of locoregional recurrence remains in the range of 7-15 %. Therefore, the search for prognostic factors for BC is of great significance. The aim of the study was to estimate the relationship betw...
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Russian Academy of Sciences, Tomsk National Research Medical Center
2023-06-01
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| Series: | Сибирский онкологический журнал |
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| Online Access: | https://www.siboncoj.ru/jour/article/view/2600 |
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| author | N. A. Alaichiev E. A. Usynin A. V. Doroshenko I. V. Kondakova E. Yu. Garbukov E. E. Sereda Zh. A. Startseva M. A. Vostrikova A. G. Ivanova |
| author_facet | N. A. Alaichiev E. A. Usynin A. V. Doroshenko I. V. Kondakova E. Yu. Garbukov E. E. Sereda Zh. A. Startseva M. A. Vostrikova A. G. Ivanova |
| author_sort | N. A. Alaichiev |
| collection | DOAJ |
| description | Background. Despite the improvement in combined modality treatment of early breast cancer (BC), the rate of locoregional recurrence remains in the range of 7-15 %. Therefore, the search for prognostic factors for BC is of great significance. The aim of the study was to estimate the relationship between clinical and morphological parameters and 10-year recurrence-free survival rate in BC patients after combined modality treatment including intraoperative radiotherapy (IOLT). Material and Methods. The study enrolled 383 patients with morphologically verified T1-3N0-1M0 stage breast cancer. The median age of the patients was 53 years (range: 28 to 80 years). All patients underwent breast-conserving surgery with IOLT delivered to the tumor bed at a single dose of 10 Gy (24.8 Gy according to the iso-effect). External beam radiation therapy (EBRT) to the conserved breast was given in the postoperative period. Results. Within the 10-year follow-up, 20 (5.2 %) locoregional recurrences occurred, of which 7 (35 %) developed with a primary tumor size of ≤ 2 cm (T1), and most recurrences - 13 (65 %) were detected with the primary tumor size corresponding to T2-3. In patients with luminal A subtype of BC and in patients with triple negative BC, the recurrence rates were 5 % and 45 %, respectively. The 10-year survival rate of patients after combined modality treatment with IOLT was 94.8 %. Conclusion. The results obtained indicate the relationship between the recurrence rate and clinical/ morphological parameters of the tumor, such as tumor size and molecular subtype. These parameters should be taken into account when planning treatment in patients with early BC. |
| format | Article |
| id | doaj-art-e854eba4498b48e5bbdce959698133d9 |
| institution | DOAJ |
| issn | 1814-4861 2312-3168 |
| language | Russian |
| publishDate | 2023-06-01 |
| publisher | Russian Academy of Sciences, Tomsk National Research Medical Center |
| record_format | Article |
| series | Сибирский онкологический журнал |
| spelling | doaj-art-e854eba4498b48e5bbdce959698133d92025-08-20T03:18:26ZrusRussian Academy of Sciences, Tomsk National Research Medical CenterСибирский онкологический журнал1814-48612312-31682023-06-01223495610.21294/1814-4861-2023-22-3-49-561132Predictors of the efficacy of intraoperative radiotherapy in organ-preserving treatment of early breast cancerN. A. Alaichiev0E. A. Usynin1A. V. Doroshenko2I. V. Kondakova3E. Yu. Garbukov4E. E. Sereda5Zh. A. Startseva6M. A. Vostrikova7A. G. Ivanova8Cancer Research Institute, Tomsk National Research Medical Center Russian Academy of SciencesCancer Research Institute, Tomsk National Research Medical Center Russian Academy of SciencesCancer Research Institute, Tomsk National Research Medical Center Russian Academy of SciencesCancer Research Institute, Tomsk National Research Medical Center Russian Academy of SciencesCancer Research Institute, Tomsk National Research Medical Center Russian Academy of SciencesCancer Research Institute, Tomsk National Research Medical Center Russian Academy of SciencesCancer Research Institute, Tomsk National Research Medical Center Russian Academy of SciencesCancer Research Institute, Tomsk National Research Medical Center Russian Academy of SciencesSiberian State Medical University of the Ministry of Health of RussiaBackground. Despite the improvement in combined modality treatment of early breast cancer (BC), the rate of locoregional recurrence remains in the range of 7-15 %. Therefore, the search for prognostic factors for BC is of great significance. The aim of the study was to estimate the relationship between clinical and morphological parameters and 10-year recurrence-free survival rate in BC patients after combined modality treatment including intraoperative radiotherapy (IOLT). Material and Methods. The study enrolled 383 patients with morphologically verified T1-3N0-1M0 stage breast cancer. The median age of the patients was 53 years (range: 28 to 80 years). All patients underwent breast-conserving surgery with IOLT delivered to the tumor bed at a single dose of 10 Gy (24.8 Gy according to the iso-effect). External beam radiation therapy (EBRT) to the conserved breast was given in the postoperative period. Results. Within the 10-year follow-up, 20 (5.2 %) locoregional recurrences occurred, of which 7 (35 %) developed with a primary tumor size of ≤ 2 cm (T1), and most recurrences - 13 (65 %) were detected with the primary tumor size corresponding to T2-3. In patients with luminal A subtype of BC and in patients with triple negative BC, the recurrence rates were 5 % and 45 %, respectively. The 10-year survival rate of patients after combined modality treatment with IOLT was 94.8 %. Conclusion. The results obtained indicate the relationship between the recurrence rate and clinical/ morphological parameters of the tumor, such as tumor size and molecular subtype. These parameters should be taken into account when planning treatment in patients with early BC.https://www.siboncoj.ru/jour/article/view/2600breast cancerlocal recurrenceintraoperative radiotherapy |
| spellingShingle | N. A. Alaichiev E. A. Usynin A. V. Doroshenko I. V. Kondakova E. Yu. Garbukov E. E. Sereda Zh. A. Startseva M. A. Vostrikova A. G. Ivanova Predictors of the efficacy of intraoperative radiotherapy in organ-preserving treatment of early breast cancer Сибирский онкологический журнал breast cancer local recurrence intraoperative radiotherapy |
| title | Predictors of the efficacy of intraoperative radiotherapy in organ-preserving treatment of early breast cancer |
| title_full | Predictors of the efficacy of intraoperative radiotherapy in organ-preserving treatment of early breast cancer |
| title_fullStr | Predictors of the efficacy of intraoperative radiotherapy in organ-preserving treatment of early breast cancer |
| title_full_unstemmed | Predictors of the efficacy of intraoperative radiotherapy in organ-preserving treatment of early breast cancer |
| title_short | Predictors of the efficacy of intraoperative radiotherapy in organ-preserving treatment of early breast cancer |
| title_sort | predictors of the efficacy of intraoperative radiotherapy in organ preserving treatment of early breast cancer |
| topic | breast cancer local recurrence intraoperative radiotherapy |
| url | https://www.siboncoj.ru/jour/article/view/2600 |
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