Changes in Retinal Oxygen Saturation 1 Month After Femtosecond LASIK Treatment in Chinese Adults with Myopia
Abstract Introduction This study aimed to compare changes in retinal oxygen saturation 1 month after femtosecond-assisted laser in situ keratomileusis (FS-LASIK) in Chinese adults with myopia using retinal oximetry. Methods In this prospective, observational, single-center cohort study, Chinese adul...
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Adis, Springer Healthcare
2025-01-01
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| Series: | Ophthalmology and Therapy |
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| Online Access: | https://doi.org/10.1007/s40123-024-01091-x |
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| author | Xiaoqi Ma Shanshan Ge Xinwei Yang Yuehua Zhou |
| author_facet | Xiaoqi Ma Shanshan Ge Xinwei Yang Yuehua Zhou |
| author_sort | Xiaoqi Ma |
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| description | Abstract Introduction This study aimed to compare changes in retinal oxygen saturation 1 month after femtosecond-assisted laser in situ keratomileusis (FS-LASIK) in Chinese adults with myopia using retinal oximetry. Methods In this prospective, observational, single-center cohort study, Chinese adults aged 18–45 years with myopia were categorized into four groups according to spherical equivalent (SE), with 66 eyes characterized as low myopia (LM −3.00D < SE ≤ −0.50D), 68 eyes as moderate myopia (MM −6.00D < SE ≤ −3.00D), 68 eyes as high myopia (HM −9.00D < SE ≤ −6.00D), and 65 eyes as super-high myopia (SHM: SE ≤ −9.00D). The following were measured before and 1 month after FS-LASIK: SE, intraocular pressure (IOP), average keratometry (Km), and axial length (AL). Other ocular biological parameters included retinal arterial oxygen saturation (SaO2) and retinal venous oxygen saturation (SvO2); parameter difference values are expressed as ∆. Results Of the 267 participants, 63.30% were female and 36.70% were male. The mean SE, AL, SaO2, and SvO2 were −5.93 ± 3.24 D, 26.01 ± 1.35 mm, 93.49% ± 1.67%, and 62.97% ± 4.52%, respectively. Before FS-LASIK, SaO2 was significantly correlated with AL and SE (r s = −0.305, P < 0.001; r s = 0.385, P < 0.001). Significant differences were found in SaO2 across myopia categories (P < 0.001). The changes in the retinal arterial oxygen saturation decreased significantly after FS-LASIK (F = 24.948, P < 0.001). After surgery, SaO2 demonstrated a statistically significant but weak negative relationship with refractive correction (ΔSE) (r s = −0.380, P < 0.001) and axial length (r s = −0.404, P < 0.001), a significant but weak positive correlation with average keratometry cutting value (ΔKm) (r s = 0.354, P < 0.001), and no correlation with the change in IOP (ΔIOP) (P > 0.05). Conclusion Ruling out the influence of refractive error, SaO2 was significantly decreased 1 month after FS-LASIK, while there was no significant change in SvO2. We conjecture that retinal amplification may affect differences in retinal oxygen saturation. |
| format | Article |
| id | doaj-art-e83fbbd798324c9f98968bfb79c32094 |
| institution | DOAJ |
| issn | 2193-8245 2193-6528 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Adis, Springer Healthcare |
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| spelling | doaj-art-e83fbbd798324c9f98968bfb79c320942025-08-20T02:48:11ZengAdis, Springer HealthcareOphthalmology and Therapy2193-82452193-65282025-01-0114354155310.1007/s40123-024-01091-xChanges in Retinal Oxygen Saturation 1 Month After Femtosecond LASIK Treatment in Chinese Adults with MyopiaXiaoqi Ma0Shanshan Ge1Xinwei Yang2Yuehua Zhou3Eye School of Chengdu, University of Traditional MedicineBeijing Ming Vision & ophthalmologyEye School of Chengdu, University of Traditional MedicineEye School of Chengdu, University of Traditional MedicineAbstract Introduction This study aimed to compare changes in retinal oxygen saturation 1 month after femtosecond-assisted laser in situ keratomileusis (FS-LASIK) in Chinese adults with myopia using retinal oximetry. Methods In this prospective, observational, single-center cohort study, Chinese adults aged 18–45 years with myopia were categorized into four groups according to spherical equivalent (SE), with 66 eyes characterized as low myopia (LM −3.00D < SE ≤ −0.50D), 68 eyes as moderate myopia (MM −6.00D < SE ≤ −3.00D), 68 eyes as high myopia (HM −9.00D < SE ≤ −6.00D), and 65 eyes as super-high myopia (SHM: SE ≤ −9.00D). The following were measured before and 1 month after FS-LASIK: SE, intraocular pressure (IOP), average keratometry (Km), and axial length (AL). Other ocular biological parameters included retinal arterial oxygen saturation (SaO2) and retinal venous oxygen saturation (SvO2); parameter difference values are expressed as ∆. Results Of the 267 participants, 63.30% were female and 36.70% were male. The mean SE, AL, SaO2, and SvO2 were −5.93 ± 3.24 D, 26.01 ± 1.35 mm, 93.49% ± 1.67%, and 62.97% ± 4.52%, respectively. Before FS-LASIK, SaO2 was significantly correlated with AL and SE (r s = −0.305, P < 0.001; r s = 0.385, P < 0.001). Significant differences were found in SaO2 across myopia categories (P < 0.001). The changes in the retinal arterial oxygen saturation decreased significantly after FS-LASIK (F = 24.948, P < 0.001). After surgery, SaO2 demonstrated a statistically significant but weak negative relationship with refractive correction (ΔSE) (r s = −0.380, P < 0.001) and axial length (r s = −0.404, P < 0.001), a significant but weak positive correlation with average keratometry cutting value (ΔKm) (r s = 0.354, P < 0.001), and no correlation with the change in IOP (ΔIOP) (P > 0.05). Conclusion Ruling out the influence of refractive error, SaO2 was significantly decreased 1 month after FS-LASIK, while there was no significant change in SvO2. We conjecture that retinal amplification may affect differences in retinal oxygen saturation.https://doi.org/10.1007/s40123-024-01091-xRetinal oxygen saturationMyopiaCorneal refractive surgeryRetinal amplificationAxial length |
| spellingShingle | Xiaoqi Ma Shanshan Ge Xinwei Yang Yuehua Zhou Changes in Retinal Oxygen Saturation 1 Month After Femtosecond LASIK Treatment in Chinese Adults with Myopia Ophthalmology and Therapy Retinal oxygen saturation Myopia Corneal refractive surgery Retinal amplification Axial length |
| title | Changes in Retinal Oxygen Saturation 1 Month After Femtosecond LASIK Treatment in Chinese Adults with Myopia |
| title_full | Changes in Retinal Oxygen Saturation 1 Month After Femtosecond LASIK Treatment in Chinese Adults with Myopia |
| title_fullStr | Changes in Retinal Oxygen Saturation 1 Month After Femtosecond LASIK Treatment in Chinese Adults with Myopia |
| title_full_unstemmed | Changes in Retinal Oxygen Saturation 1 Month After Femtosecond LASIK Treatment in Chinese Adults with Myopia |
| title_short | Changes in Retinal Oxygen Saturation 1 Month After Femtosecond LASIK Treatment in Chinese Adults with Myopia |
| title_sort | changes in retinal oxygen saturation 1 month after femtosecond lasik treatment in chinese adults with myopia |
| topic | Retinal oxygen saturation Myopia Corneal refractive surgery Retinal amplification Axial length |
| url | https://doi.org/10.1007/s40123-024-01091-x |
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