Stem Cells: Innovations in Clinical Applications
The use of mesenchymal stem cells (MSCs) as clinical therapeutics is a relatively new avenue of study for treatment of a variety of diseases. The therapeutic impact of the MSCs is based upon their multiplicities of function and interaction with host tissues. MSCs can be anti-inflammatory, antifibro...
Saved in:
| Main Authors: | , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2014-01-01
|
| Series: | Stem Cells International |
| Online Access: | http://dx.doi.org/10.1155/2014/516278 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1849691508895121408 |
|---|---|
| author | Morgan T. Sutton Tracey L. Bonfield |
| author_facet | Morgan T. Sutton Tracey L. Bonfield |
| author_sort | Morgan T. Sutton |
| collection | DOAJ |
| description | The use of mesenchymal stem cells (MSCs) as clinical therapeutics is a relatively new avenue of study for treatment of a variety of diseases. The therapeutic impact of the MSCs is based upon their multiplicities of function and interaction with host tissues. MSCs can be anti-inflammatory, antifibrotic, antimicrobial, and regenerative, all which may improve outcomes in scenarios of damaged tissues and inflammation. Although most studies focus on utilizing MSCs to direct clinical efficacy, it is the ability to orchestrate host response in surrounding tissue that is especially unique and versatile. This orchestration of host response can be applied to a variety of clinical scenarios not only through cell-cell interactions but also through production of bioactive secreted factors. These bioactive factors include small proteins, chemokines, cytokines, and other cellular regulators. These factors have the capacity to induce angiogenesis or blood vessel development, be chemotactic, and induce cellular recruitment. MSCs also have the capacity to differentiate with the implicated environment to regenerate tissue or accommodate host tissue in a cell specific manner. The differentiation cannot only be done in vivo but also can be optimized in vitro prior to in vivo administration, potentiating the versatility of the MSCs and opening avenues for corrective therapy and cell delivery of genes. The differentiation process depends on the environment with which the MSCs are put and results in active communication between the newly administered cells host tissue. Since these properties have been identified, there are a variety of clinical trials and studies being conducted on MSCs ability to treat human disease. This review outlines the potential use of MSCs, the types of tissue, and the innovative applications of MSCs for the treatment of diseases. |
| format | Article |
| id | doaj-art-e83cab38f1414e0ba19b1f17d9e9dbaa |
| institution | DOAJ |
| issn | 1687-966X 1687-9678 |
| language | English |
| publishDate | 2014-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Stem Cells International |
| spelling | doaj-art-e83cab38f1414e0ba19b1f17d9e9dbaa2025-08-20T03:21:01ZengWileyStem Cells International1687-966X1687-96782014-01-01201410.1155/2014/516278516278Stem Cells: Innovations in Clinical ApplicationsMorgan T. Sutton0Tracey L. Bonfield1Department of Pediatrics, Case Western Reserve University, Cleveland, OH 44106-4948, USADepartment of Pediatrics, Case Western Reserve University, Cleveland, OH 44106-4948, USAThe use of mesenchymal stem cells (MSCs) as clinical therapeutics is a relatively new avenue of study for treatment of a variety of diseases. The therapeutic impact of the MSCs is based upon their multiplicities of function and interaction with host tissues. MSCs can be anti-inflammatory, antifibrotic, antimicrobial, and regenerative, all which may improve outcomes in scenarios of damaged tissues and inflammation. Although most studies focus on utilizing MSCs to direct clinical efficacy, it is the ability to orchestrate host response in surrounding tissue that is especially unique and versatile. This orchestration of host response can be applied to a variety of clinical scenarios not only through cell-cell interactions but also through production of bioactive secreted factors. These bioactive factors include small proteins, chemokines, cytokines, and other cellular regulators. These factors have the capacity to induce angiogenesis or blood vessel development, be chemotactic, and induce cellular recruitment. MSCs also have the capacity to differentiate with the implicated environment to regenerate tissue or accommodate host tissue in a cell specific manner. The differentiation cannot only be done in vivo but also can be optimized in vitro prior to in vivo administration, potentiating the versatility of the MSCs and opening avenues for corrective therapy and cell delivery of genes. The differentiation process depends on the environment with which the MSCs are put and results in active communication between the newly administered cells host tissue. Since these properties have been identified, there are a variety of clinical trials and studies being conducted on MSCs ability to treat human disease. This review outlines the potential use of MSCs, the types of tissue, and the innovative applications of MSCs for the treatment of diseases.http://dx.doi.org/10.1155/2014/516278 |
| spellingShingle | Morgan T. Sutton Tracey L. Bonfield Stem Cells: Innovations in Clinical Applications Stem Cells International |
| title | Stem Cells: Innovations in Clinical Applications |
| title_full | Stem Cells: Innovations in Clinical Applications |
| title_fullStr | Stem Cells: Innovations in Clinical Applications |
| title_full_unstemmed | Stem Cells: Innovations in Clinical Applications |
| title_short | Stem Cells: Innovations in Clinical Applications |
| title_sort | stem cells innovations in clinical applications |
| url | http://dx.doi.org/10.1155/2014/516278 |
| work_keys_str_mv | AT morgantsutton stemcellsinnovationsinclinicalapplications AT traceylbonfield stemcellsinnovationsinclinicalapplications |