Wells Syndrome in Children: Case Study and Differential Diagnostics
Background. Wells syndrome (eosinophilic cellulitis) is recurrent granulomatous dermatitis with peripheral blood eosinophilia. This is extremely rare pathology, therefore, there are no reliable epidemiological data on its prevalence. Only about 200 cases were recorded worldwide and 30 of them among...
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"Paediatrician" Publishers LLC
2020-12-01
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| Series: | Вопросы современной педиатрии |
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| Online Access: | https://vsp.spr-journal.ru/jour/article/view/2511 |
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| author | Nikolay N. Murashkin Eduard T. Ambarchian Roman V. Epishev Alexander I. Materikin Leonid A. Opryatin Roman A. Ivanov Daria S. Kukoleva |
| author_facet | Nikolay N. Murashkin Eduard T. Ambarchian Roman V. Epishev Alexander I. Materikin Leonid A. Opryatin Roman A. Ivanov Daria S. Kukoleva |
| author_sort | Nikolay N. Murashkin |
| collection | DOAJ |
| description | Background. Wells syndrome (eosinophilic cellulitis) is recurrent granulomatous dermatitis with peripheral blood eosinophilia. This is extremely rare pathology, therefore, there are no reliable epidemiological data on its prevalence. Only about 200 cases were recorded worldwide and 30 of them among children according to the meta-analysis (2012). The disease is mostly sporadic, there are rare family cases, according to the results of little number of scientific publications.Clinical Case Description. The clinical case of Wells syndrome in female 4 years old patient is presented. Clinical findings included symmetrical skin lesions, nodes and large irregular edematous plaques of red-purple color with clear fluid vesicles on its surface. The disease had wavy course: rashes have recovered spontaneously over 7–10 days, new elements appeared alongside with feeling unwell, fever up to 37,8°C and abdominal pain. Similar clinical findings of rashes were observed in paternal relatives of the child.Conclusion. Differential diagnostics of Wells syndrome should be carried out with skin granulomatous diseases and hypereosinophilic syndrome that may be characterized by similar clinical findings. Verification of Wells syndrome diagnosis is complicated due to its rareness, low awareness of dermatologists and pediatricians about this pathology, as well as ignoring the need to carry out histological tests during the disease exacerbation. |
| format | Article |
| id | doaj-art-e8397588cf5a4d26a23175a29218813c |
| institution | DOAJ |
| issn | 1682-5527 1682-5535 |
| language | English |
| publishDate | 2020-12-01 |
| publisher | "Paediatrician" Publishers LLC |
| record_format | Article |
| series | Вопросы современной педиатрии |
| spelling | doaj-art-e8397588cf5a4d26a23175a29218813c2025-08-20T03:21:55Zeng"Paediatrician" Publishers LLCВопросы современной педиатрии1682-55271682-55352020-12-0119649049510.15690/vsp.v19i6.21561919Wells Syndrome in Children: Case Study and Differential DiagnosticsNikolay N. Murashkin0Eduard T. Ambarchian1Roman V. Epishev2Alexander I. Materikin3Leonid A. Opryatin4Roman A. Ivanov5Daria S. Kukoleva6National Medical Research Center of Children’s Health; Research Institute of Pediatrics and Children’s Health in “Central Clinical Hospital of the Russian Academy of Sciences”; Sechenov First Moscow State Medical University (Sechenov University); Central State Medical Academy of Department of Presidential AffairsNational Medical Research Center of Children’s Health; Research Institute of Pediatrics and Children’s Health in “Central Clinical Hospital of the Russian Academy of Sciences”National Medical Research Center of Children’s Health; Research Institute of Pediatrics and Children’s Health in “Central Clinical Hospital of the Russian Academy of Sciences”National Medical Research Center of Children’s HealthNational Medical Research Center of Children’s HealthNational Medical Research Center of Children’s HealthNational Medical Research Center of Children’s HealthBackground. Wells syndrome (eosinophilic cellulitis) is recurrent granulomatous dermatitis with peripheral blood eosinophilia. This is extremely rare pathology, therefore, there are no reliable epidemiological data on its prevalence. Only about 200 cases were recorded worldwide and 30 of them among children according to the meta-analysis (2012). The disease is mostly sporadic, there are rare family cases, according to the results of little number of scientific publications.Clinical Case Description. The clinical case of Wells syndrome in female 4 years old patient is presented. Clinical findings included symmetrical skin lesions, nodes and large irregular edematous plaques of red-purple color with clear fluid vesicles on its surface. The disease had wavy course: rashes have recovered spontaneously over 7–10 days, new elements appeared alongside with feeling unwell, fever up to 37,8°C and abdominal pain. Similar clinical findings of rashes were observed in paternal relatives of the child.Conclusion. Differential diagnostics of Wells syndrome should be carried out with skin granulomatous diseases and hypereosinophilic syndrome that may be characterized by similar clinical findings. Verification of Wells syndrome diagnosis is complicated due to its rareness, low awareness of dermatologists and pediatricians about this pathology, as well as ignoring the need to carry out histological tests during the disease exacerbation.https://vsp.spr-journal.ru/jour/article/view/2511childrenwells syndromeeosinophilic cellulitis |
| spellingShingle | Nikolay N. Murashkin Eduard T. Ambarchian Roman V. Epishev Alexander I. Materikin Leonid A. Opryatin Roman A. Ivanov Daria S. Kukoleva Wells Syndrome in Children: Case Study and Differential Diagnostics Вопросы современной педиатрии children wells syndrome eosinophilic cellulitis |
| title | Wells Syndrome in Children: Case Study and Differential Diagnostics |
| title_full | Wells Syndrome in Children: Case Study and Differential Diagnostics |
| title_fullStr | Wells Syndrome in Children: Case Study and Differential Diagnostics |
| title_full_unstemmed | Wells Syndrome in Children: Case Study and Differential Diagnostics |
| title_short | Wells Syndrome in Children: Case Study and Differential Diagnostics |
| title_sort | wells syndrome in children case study and differential diagnostics |
| topic | children wells syndrome eosinophilic cellulitis |
| url | https://vsp.spr-journal.ru/jour/article/view/2511 |
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