Causal association of cathepsins with female infertility: a bidirectional Mendelian randomization analysis
Objective This study aimed to systematically evaluate potential causal relationships between nine cathepsins and female infertility using Mendelian randomization (MR) methods. Methods A bidirectional MR analysis was conducted utilizing single nucleotide polymorphisms as instrumental variables to inv...
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| Format: | Article |
| Language: | English |
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Korean Society of Obstetrics and Gynecology
2025-05-01
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| Series: | Obstetrics & Gynecology Science |
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| Online Access: | http://www.ogscience.org/upload/pdf/ogs-24254.pdf |
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| author | Lidan Liu Ming Liao Bo Liu Qianyi Huang Huimei Wu Mujun Li |
| author_facet | Lidan Liu Ming Liao Bo Liu Qianyi Huang Huimei Wu Mujun Li |
| author_sort | Lidan Liu |
| collection | DOAJ |
| description | Objective This study aimed to systematically evaluate potential causal relationships between nine cathepsins and female infertility using Mendelian randomization (MR) methods. Methods A bidirectional MR analysis was conducted utilizing single nucleotide polymorphisms as instrumental variables to investigate the potential causal effects between nine cathepsins and female infertility. Genetic data on female infertility were sourced from the FinnGen study, and cathepsin-related data were obtained from genome-wide association studies datasets of European ancestry. Results Elevated levels of cathepsin E were significantly and inversely associated with the risk of female infertility, suggesting a potential protective role. This finding was further supported by multivariable MR analysis. However, no significant associations were observed between the other eight cathepsins and female infertility. Conclusion This study represents the first systematic MR analysis to identify a potential protective effect of cathepsin E on female infertility. |
| format | Article |
| id | doaj-art-e835b1a54c9d4dd59dca92f49e031d32 |
| institution | OA Journals |
| issn | 2287-8580 |
| language | English |
| publishDate | 2025-05-01 |
| publisher | Korean Society of Obstetrics and Gynecology |
| record_format | Article |
| series | Obstetrics & Gynecology Science |
| spelling | doaj-art-e835b1a54c9d4dd59dca92f49e031d322025-08-20T01:56:49ZengKorean Society of Obstetrics and GynecologyObstetrics & Gynecology Science2287-85802025-05-0168323724310.5468/ogs.242548870Causal association of cathepsins with female infertility: a bidirectional Mendelian randomization analysisLidan Liu0Ming Liao1Bo Liu2Qianyi Huang3Huimei Wu4Mujun Li5 Guangxi Reproductive Medical Center, The First Affiliated Hospital of Guangxi Medical University, Nanning, China Guangxi Reproductive Medical Center, The First Affiliated Hospital of Guangxi Medical University, Nanning, China Guangxi Reproductive Medical Center, The First Affiliated Hospital of Guangxi Medical University, Nanning, China Guangxi Reproductive Medical Center, The First Affiliated Hospital of Guangxi Medical University, Nanning, China Guangxi Reproductive Medical Center, The First Affiliated Hospital of Guangxi Medical University, Nanning, China Guangxi Reproductive Medical Center, The First Affiliated Hospital of Guangxi Medical University, Nanning, ChinaObjective This study aimed to systematically evaluate potential causal relationships between nine cathepsins and female infertility using Mendelian randomization (MR) methods. Methods A bidirectional MR analysis was conducted utilizing single nucleotide polymorphisms as instrumental variables to investigate the potential causal effects between nine cathepsins and female infertility. Genetic data on female infertility were sourced from the FinnGen study, and cathepsin-related data were obtained from genome-wide association studies datasets of European ancestry. Results Elevated levels of cathepsin E were significantly and inversely associated with the risk of female infertility, suggesting a potential protective role. This finding was further supported by multivariable MR analysis. However, no significant associations were observed between the other eight cathepsins and female infertility. Conclusion This study represents the first systematic MR analysis to identify a potential protective effect of cathepsin E on female infertility.http://www.ogscience.org/upload/pdf/ogs-24254.pdfcathepsin efemale infertilitymendelian randomization |
| spellingShingle | Lidan Liu Ming Liao Bo Liu Qianyi Huang Huimei Wu Mujun Li Causal association of cathepsins with female infertility: a bidirectional Mendelian randomization analysis Obstetrics & Gynecology Science cathepsin e female infertility mendelian randomization |
| title | Causal association of cathepsins with female infertility: a bidirectional Mendelian randomization analysis |
| title_full | Causal association of cathepsins with female infertility: a bidirectional Mendelian randomization analysis |
| title_fullStr | Causal association of cathepsins with female infertility: a bidirectional Mendelian randomization analysis |
| title_full_unstemmed | Causal association of cathepsins with female infertility: a bidirectional Mendelian randomization analysis |
| title_short | Causal association of cathepsins with female infertility: a bidirectional Mendelian randomization analysis |
| title_sort | causal association of cathepsins with female infertility a bidirectional mendelian randomization analysis |
| topic | cathepsin e female infertility mendelian randomization |
| url | http://www.ogscience.org/upload/pdf/ogs-24254.pdf |
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